ChemicalBook > CAS DataBase List > BEAUVERICIN

BEAUVERICIN

Product Name: BEAUVERICIN
CAS No.: 26048-05-5
Chemical Name: BEAUVERICIN
Synonyms: nivea;bovein;bassiana;beauverin;Beauveria;BEAUVERICIN;BEAUVERFICIN;Beauveria sp.;Beauvericin 97%;13C45-Beauvericin
CBNumber: CB4345714
Molecular Formula: C45H57N3O9
Formula Weight: 783.95
MOL File: 26048-05-5.mol

Less

BEAUVERICIN Property

Melting point:: 93-94℃
Boiling point:: 975.6±65.0 °C(Predicted)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (30 mg/ml)
pka: -1.02±0.70(Predicted)
form: Solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: GYSCAQFHASJXRS-ABKJGVMTSA-N
SMILES: C(C1C=CC=CC=1)C1C(OC(C(N(C(C(OC(C(C)C)C(=O)N(C)C(CC2C=CC=CC=2)C(=O)OC(C(C)C)C(=O)N1C)=O)CC1C=CC=CC=1)C)=O)C(C)C)=O

Less

Safety

WGK Germany: 3
HS Code: 29419090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B7510
Product name: Beauvericin
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $234
Updated: 2025/07/31

Sigma-Aldrich

Product number: 37012
Product name: Beauvericin
Purity: VETRANAL?, analytical standard
Packaging: 100μg
Price: $895
Updated: 2022/05/15

Cayman Chemical

Product number: 11426
Product name: Beauvericin
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11426
Product name: Beauvericin
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 11426
Product name: Beauvericin
Purity: ≥95%
Packaging: 10mg
Price: $261
Updated: 2024/03/01

Less

BEAUVERICIN Chemical Properties,Usage,Production

Description

Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain barrier in mice.4 Inhibits HIV-1 integrase.5

Chemical Properties

White powder

Uses

Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin exhibits ionophoric properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels.

Uses

Toxic depsipeptide with antibiotic and insecticidal effects.Beauvericin is a toxic depsipeptide with antibiotic and insecticidal effects.

Definition

ChEBI: A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues.

in vivo

Beauvericin (5 mg/kg; i.p.; after the first dosing cycle, observe for two days and continue the second dosing cycle) reduces tumor volume and increases necrosis in allogeneic transplant model mice^[3]. Beauvericin (3, 5, 7 mg/kg; i.p.; once a week for three weeks) can significantly inhibit the growth of H22 allogeneic transplant model mice and increase the levels of TNF-α and IL-2 in mice^[5].

Animal Model:	BALB/c mice injected subcutaneously with mouse CT-26 colon cancer cells on the right side^[3]
Dosage:	5 mg/kg
Administration:	ntraperitoneal injection (i.p.)；The drug was administered on the third day after the injection of colon cancer cells and continued once a day for five days, then stopped for two days of observation, and continued on the tenth day after the injection of colon cancer cells, and continued once a day for four days.
Result:	Reduced the average tumor volume by 52.8 % and the average tumor weight by 60 %.

Animal Model:	Human cervical cancer KB-3-1 xenograft mouse model^[3]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.)； The drug was administered once a day starting on the fifth day after cervical cancer injection for five days, followed by two days of observation. The drug was administered once a day starting on the twelfth day after cervical cancer cell injection for four days.
Result:	Reduced the average tumor volume by 31.3 % and the average tumor weight by 31.2 %.

IC 50

ACAT

References

[1] CHIEN-LIN LU. Beauvericin-induced cell apoptosis through the mitogen-activated protein kinase pathway in human nonsmall cell lung cancer A549 cells.[J]. Journal of Toxicological Sciences, 2016, 41 3: 429-437. DOI:10.2131/jts.41.429
[2] ANTON A. TONSHIN . The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis[J]. Toxicology, 2010, 276 1: Pages 49-57. DOI:10.1016/j.tox.2010.07.001
[3] TANVI SHEKHAR-GUTURJA. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling[J]. Nature chemical biology, 2016, 12 10: 867-875. DOI:10.1038/nchembio.2165
[4] LIEN TAEVERNIER . Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins[J]. Toxicology letters, 2016, 258: Pages 175-184. DOI:10.1016/j.toxlet.2016.06.1741
[5] CHA-GYUN SHIN. Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase[J]. Journal of Antibiotics, 2009, 62 12: 687-690. DOI:10.1038/ja.2009.102

BEAUVERICIN Preparation Products And Raw materials

Raw materials

Filler Potassium Phosphate Monobasic

Preparation Products

Less

BEAUVERICIN Suppliers

Canada 1 China 190 Germany 1 India 1 Switzerland 1 United Kingdom 6 United States 18 USA 1 Global 219

Meite (Hubei) New Materials Co., Ltd

Tel: 13517221830
Email: 18802755@qq.com
Country: China
ProdList: 2498
Advantage: 58

Wuhan Chujiang Haoyu Chemical Technology Development Co., Ltd.

Tel: 18171284407
Email: 1850853183@qq.com
Country: China
ProdList: 307
Advantage: 58

WUHAN GEEYESCHEM CHEMICAL CO., LTD.

Tel: 15927657268
Email: 1916972268@qq.com
Country: China
ProdList: 2082
Advantage: 58

Wuhan Jiyesheng Chemical Co. , Ltd.

Tel: 159-27657172 15927657172
Email: 2092950792@qq.com
Country: China
ProdList: 2069
Advantage: 58

Qingdao IniKem BioPharmaTech Co.,Ltd

Tel: 0532-58268780 18561687109;
Fax: -
Email: sales@inikem.com
Country: China
ProdList: 299
Advantage: 55

Hubei Hongyun long biological technology Co. Ltd.

Tel: 13554337556 13554337556
Email: 342063746@qq.com
Country: China
ProdList: 1773
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Jinxiang Chemical (Danyang) Products Co., Ltd.

Tel: 025-86819862 13913839793
Fax: 0086-25-86819859
Email: nancyzong@jinchemical.com
Country: China
ProdList: 97
Advantage: 74

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6116
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Wuhai Shuou Technology Co., Ltd.

Tel: 17792809151
Fax: 18872220797
Email: 2355916837@ycphar.com
Country: China
ProdList: 6133
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

JIANGYIN RUISHIPHARM CO.,LIMITED

Tel: 0510-0510-66227179 18921203887
Fax: +86-0510-66227179 QQ:2200317867
Email: sales@ruishipharm.com
Country: China
ProdList: 749
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hubei Xingyinhe Chemical Co., Ltd.

Tel: 15308653513
Fax: 027-63606400
Email: hubeixyh@qq.com
Country: China
ProdList: 700
Advantage: 58

Wuhan Mengqi Technology Co., Ltd.

Tel: 027-83232706 15871702139
Email: 3454407469@qq.com
Country: China
ProdList: 662
Advantage: 58

Chengdu Glip Biotechnology Co., Ltd.

Tel: 028-87075086 18030859262
Email: 2851503756@qq.com
Country: China
ProdList: 1928
Advantage: 58

Wuhan Jiyesheng Chemical Co., Ltd.

Tel: 15827541030
Email: 3109593928@qq.com
Country: China
ProdList: 91
Advantage: 58

Hubei Xingyinhe Chemical Co., Ltd.

Tel: 13307112120
Email: 1506207717@qq.com
Country: CHINA
ProdList: 630
Advantage: 58

uhan Jiye Chemical Co., Ltd.

Tel: 13545234822
Country: CHINA
ProdList: 664
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Wuhan Demeikai Biotechnology Co., Ltd

Tel: +8618942921723
Email: info@dmksw.xin
Country: China
ProdList: 717
Advantage: 58

Shanghai Biolang Biotechnology Co., Ltd.

Tel: +86-15970428662 +86-13397199602
Fax: +8613397199602
Email: Niky@biolang.cn
Country: China
ProdList: 515
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10237
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

HONG KONG IPURE BIOLOGY CO.,LIMITED

Tel: 86 18062405514 18062405514
Email: ada@ipurechemical.com
Country: CHINA
ProdList: 3461
Advantage: 58

Longyan Tianhua Biological Technology Co., Ltd

Tel: 0086 18039857276 18039857276
Country: CHINA
ProdList: 2783
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Shandong chuangyingchemical Co., Ltd.

Tel: 18853181302
Email: sale@chuangyingchem.com
Country: CHINA
ProdList: 5906
Advantage: 58

Hubei Xingyinhe Chemical Co., Ltd.

Tel: 13437271305
Email: 1961141534@qq.com
Country: China
ProdList: 643
Advantage: 58

Wuhan jiyesheng Chemical Co., Ltd

Tel: 15927657268
Email: 1916972268@qq.com
Country: CHINA
ProdList: 168
Advantage: 58

Less

View Lastest Price from BEAUVERICIN manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: BEAUVERICIN 26048-05-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: BEAUVERICIN 26048-05-5
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-24

Shanghai Biolang Biotechnology Co., Ltd.

Product: BEAUVERICIN 26048-05-5
Price: US $9.90-7.70/g
Min. Order: 10g
Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
Supply Ability: 1000kgs
Release date: 2022-02-18

26048-05-5, BEAUVERICINRelated Search:

Emamectin Bis(2-dimethylaminoethyl) ether 2-((2-(2-(DIMETHYLAMINO)ETHOXY)ETHYL) METHYLAMINO)ETHANOL, 97 1,5-DIAMINO-3-OXAPENTANE GLYCINE N-PROPYL ESTER HYDROCHLORIDE N,N-Dimethylglycine ethyl ester Propanamide, 2-hydroxy-N,N-dimethyl- (9CI) N-(2-HYDROXYETHYL)LACTAMIDE N,N-DIMETHYL-L-PHENYLALANINE BEAUVERICIN 1,5-BIS(METHYLAMINO)-3-OXAPENTANE, 98 AC-PHE-OET N,N-DIMETHYL-2-METHOXYACETAMIDE AC-PHE-OME ethyl 2-(propylamino)acetate beauvericin synthetase ethyl 2-(butylamino)acetate N,N-DI(2-METHOXY)ETHYLAMMONIUM ACETATE

Beauvericin, froM Beauveria bassiana

CYCLO-[D-ALPHA-HYDROXYISOVALERYL-L-N-METHYLPHENYLALANYL]3

CYCLO(-D-ALPHA-HYDROXYISOVALERYL-N-ME-PHE)3

BEAUVERICIN

cyclo(d-α-hydroxyisovaleryl-l-n-methyl-phe)3

BEAUVERFICIN

beauverin

beauverin bassiaua vuillemin

bovein

Beauvericin 97%

Cyclo[(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl-(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl-(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl]

Cyclo(-D-a-hydroxyisovaleryl-N-Me-Phe)3

Beauvericin, 99%, from Beauveria bassiana

N-Methylcyclo(L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-)

Beauveria

Beauveria Vuillemin

Beauveria Vuillemin sp

nivea

bassiana

Beauveria sp.

Beauveria bassiana (Bals.-Criv.) Vuill.

Beauveria bassiana (Balsamo) Vuillemin

Beauveria bassiana AS 3.4271

Beauveria brongiartii

BEAUVERICIN USP/EP/BP

13C45-Beauvericin

(3S,6R,9S,12R,15S,18R)-3,9,15-Tribenzyl-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone

(3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-4,10,16-trimethyl-6,12,18-tris(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

Beauvericin in dried down

Beauvericin 100 μg/ml Acetonitrile

Beauvericin in Acetonitrile

Beauvericin, 10 mM in DMSO

26048-05-5

63428-80-0

C45H57N3O9

C44H57N3O8

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Peptides

Other Peptides

Antibiotic

Intermediates & Fine Chemicals

Peptides

Pharmaceuticals

peptide