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BEAUVERICIN

Product Name
BEAUVERICIN
CAS No.
26048-05-5
Chemical Name
BEAUVERICIN
Synonyms
nivea;bovein;bassiana;beauverin;Beauveria;BEAUVERICIN;BEAUVERFICIN;Beauveria sp.;Beauvericin 97%;13C45-Beauvericin
CBNumber
CB4345714
Molecular Formula
C45H57N3O9
Formula Weight
783.95
MOL File
26048-05-5.mol
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BEAUVERICIN Property

Melting point:
93-94℃
Boiling point:
975.6±65.0 °C(Predicted)
Density 
1.126±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (30 mg/ml)
pka
-1.02±0.70(Predicted)
form 
Solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
GYSCAQFHASJXRS-ABKJGVMTSA-N
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Safety

WGK Germany 
3
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B7510
Product name
Beauvericin
Purity
≥97% (HPLC)
Packaging
5mg
Price
$218
Updated
2024/03/01
Sigma-Aldrich
Product number
37012
Product name
Beauvericin
Purity
VETRANAL?, analytical standard
Packaging
100μg
Price
$895
Updated
2022/05/15
Cayman Chemical
Product number
11426
Product name
Beauvericin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11426
Product name
Beauvericin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
11426
Product name
Beauvericin
Purity
≥95%
Packaging
10mg
Price
$261
Updated
2024/03/01
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BEAUVERICIN Chemical Properties,Usage,Production

Description

Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain barrier in mice.4 Inhibits HIV-1 integrase.5

Chemical Properties

White powder

Uses

Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin exhibits ionophoric properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels.

Uses

Toxic depsipeptide with antibiotic and insecticidal effects.Beauvericin is a toxic depsipeptide with antibiotic and insecticidal effects.

Definition

ChEBI: A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues.

References

1) Lu et al. (2016), Beauvericin-induced cell apoptosis through the mitogen-activated protein kinase pathway in human nonsmall cell lung cancer A549 cells.; J. Toxicol. Sci., 41 429 2) Tonshin et al. (2010), The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis.; Toxicology, 276 49 3) Shekhar-Guturja et al. (2016), Dual action antifungal small molecule modulates multidrug efflux and TOR signaling; Nat. Chem. Biol., 12 867 4) Taevernier et al. (2016), Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins; Toxicol. Lett., 258 175 5) Shin et al. (2009), Beauvericin and enniatins H,I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase; J. Antibiot. (Tokyo), 62 687

BEAUVERICIN Preparation Products And Raw materials

Raw materials

Filler Potassium Phosphate Monobasic

Preparation Products

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View Lastest Price from BEAUVERICIN manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
BEAUVERICIN 26048-05-5
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24
Hebei Zhuanglai Chemical Trading Co Ltd
Product
BEAUVERICIN 26048-05-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-29
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
Product
BEAUVERICIN 26048-05-5
Price
US $18.00/kg
Min. Order
1kg
Purity
99.9
Supply Ability
5000
Release date
2024-05-10

26048-05-5, BEAUVERICINRelated Search:

Emamectin Bis(2-dimethylaminoethyl) ether 2-((2-(2-(DIMETHYLAMINO)ETHOXY)ETHYL) METHYLAMINO)ETHANOL, 97 1,5-DIAMINO-3-OXAPENTANE GLYCINE N-PROPYL ESTER HYDROCHLORIDE N,N-Dimethylglycine ethyl ester Propanamide, 2-hydroxy-N,N-dimethyl- (9CI) N-(2-HYDROXYETHYL)LACTAMIDE N,N-DIMETHYL-L-PHENYLALANINE BEAUVERICIN 1,5-BIS(METHYLAMINO)-3-OXAPENTANE, 98 AC-PHE-OET N,N-DIMETHYL-2-METHOXYACETAMIDE AC-PHE-OME ethyl 2-(propylamino)acetate beauvericin synthetase ethyl 2-(butylamino)acetate N,N-DI(2-METHOXY)ETHYLAMMONIUM ACETATE

  • Beauvericin, froM Beauveria bassiana
  • CYCLO-[D-ALPHA-HYDROXYISOVALERYL-L-N-METHYLPHENYLALANYL]3
  • CYCLO(-D-ALPHA-HYDROXYISOVALERYL-N-ME-PHE)3
  • BEAUVERICIN
  • cyclo(d-α-hydroxyisovaleryl-l-n-methyl-phe)3
  • BEAUVERFICIN
  • beauverin
  • beauverin bassiaua vuillemin
  • bovein
  • Beauvericin 97%
  • Cyclo[(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl-(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl-(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl]
  • Cyclo(-D-a-hydroxyisovaleryl-N-Me-Phe)3
  • Beauvericin, 99%, from Beauveria bassiana
  • N-Methylcyclo(L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-)
  • Beauveria
  • Beauveria Vuillemin
  • Beauveria Vuillemin sp
  • nivea
  • bassiana
  • Beauveria sp.
  • Beauveria bassiana (Bals.-Criv.) Vuill.
  • Beauveria bassiana (Balsamo) Vuillemin
  • Beauveria bassiana AS 3.4271
  • Beauveria brongiartii
  • BEAUVERICIN USP/EP/BP
  • 13C45-Beauvericin
  • (3S,6R,9S,12R,15S,18R)-3,9,15-Tribenzyl-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone
  • (3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-4,10,16-trimethyl-6,12,18-tris(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
  • Beauvericin in dried down
  • Beauvericin 100 μg/ml Acetonitrile
  • Beauvericin in Acetonitrile
  • Beauvericin, 10 mM in DMSO
  • 26048-05-5
  • 63428-80-0
  • C45H57N3O9
  • C44H57N3O8
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