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PD 404182

Product Name
PD 404182
CAS No.
72596-74-8
Chemical Name
PD 404182
Synonyms
PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-;3,4-Dihydro-2H,6H-benzo[e]pyrimido[1,2-c][1,3]thiazin-6-imine;6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
CBNumber
CB4347334
Molecular Formula
C11H11N3S
Formula Weight
217.29
MOL File
Mol file
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PD 404182 Property

Boiling point:
366.8±25.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥22 mg/mL, soluble
pka
6.27±0.20(Predicted)
form 
powder
color 
Light yellow to yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P218370
Product name
PD404182
Packaging
10mg
Price
$175
Updated
2021/12/16
TRC
Product number
P218370
Product name
PD404182
Packaging
50mg
Price
$795
Updated
2021/12/16
TRC
Product number
P218370
Product name
PD404182
Packaging
100mg
Price
$1400
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008474
Product name
PD-404,182
Purity
95.00%
Packaging
2MG
Price
$610.88
Updated
2021/12/16
DC Chemicals
Product number
001639
Product name
PD404182
Packaging
004
Price
$850
Updated
2021/12/16
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PD 404182 Chemical Properties,Usage,Production

Uses

PD 404182 is an inhibitor of SARS-CoV-2

Enzyme inhibitor

This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.

PD 404182 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 404182 Suppliers

Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
3525
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32079
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
68144
Advantage
58

72596-74-8, PD 404182Related Search:


  • 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
  • PD 404,182
  • 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
  • 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
  • 3,4-Dihydro-2H,6H-benzo[e]pyrimido[1,2-c][1,3]thiazin-6-imine
  • 2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-
  • 72596-74-8