PD 404182

Product Name: PD 404182
CAS No.: 72596-74-8
Chemical Name: PD 404182
Synonyms: PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-;3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine;6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
CBNumber: CB4347334
Molecular Formula: C11H11N3S
Formula Weight: 217.29
MOL File: Mol file

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PD 404182 Property

Boiling point:: 366.8±25.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥22 mg/mL, soluble
pka: 6.27±0.20(Predicted)
form: powder

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P218370
Product name: PD404182
Packaging: 10mg
Price: $175
Updated: 2021/12/16

TRC

Product number: P218370
Product name: PD404182
Packaging: 50mg
Price: $795
Updated: 2021/12/16

TRC

Product number: P218370
Product name: PD404182
Packaging: 100mg
Price: $1400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008474
Product name: PD-404,182
Purity: 95.00%
Packaging: 2MG
Price: $610.88
Updated: 2021/12/16

DC Chemicals

Product number: 001639
Product name: PD404182
Packaging: 004
Price: $850
Updated: 2021/12/16

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PD 404182 Chemical Properties,Usage,Production

Uses

PD 404182 is an inhibitor of SARS-CoV-2

Enzyme inhibitor

This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.

PD 404182 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 404182 Suppliers

China 8 Switzerland 1 United Kingdom 1 United States 4 USA 1 Global 15

Shanghai Raise Chemical Technology Co.,Ltd

Tel: 15026594951
Fax: 0556-5030632
Email: rs@raise-chem.com
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
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DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.com
Country: China
ProdList: 24246
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72596-74-8, PD 404182Related Search:

6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE

PD 404,182

3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine

2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-

72596-74-8