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LOFEPRAMINE HYDROCHLORIDE

Product Name
LOFEPRAMINE HYDROCHLORIDE
CAS No.
26786-32-3
Chemical Name
LOFEPRAMINE HYDROCHLORIDE
Synonyms
db-2182;WHR 2908A;WHR-2908A;ropylaminehcl;LOFEPRAMINE HCL;acetophenonehcl;leo640hydrochloride;iopraminehydrochloride;lopraminehydrochloride;clopepraminehydrochloride
CBNumber
CB4351274
Molecular Formula
C26H28Cl2N2O
Formula Weight
455.42
MOL File
26786-32-3.mol
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LOFEPRAMINE HYDROCHLORIDE Property

Melting point:
152-154°
Flash point:
9℃
storage temp. 
2-8°C
solubility 
DMSO: ~24 mg/mL
form 
solid
color 
off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37-53
Safety Statements 
22-24/25-26-28-36/37/39-38
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
AM6485000
Toxicity
LD50 in mice, rats (mg/kg): >2500, >1000 orally; 920, >1000 i.p.; >1000, >1000 s.c. (Eriksoo, Rohte)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H290May be corrosive to metals

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0006780
Product name
LOFEPRAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$779.45
Updated
2021/12/16
AHH
Product number
MT-53291
Product name
Lofepramine hydrochloride
Purity
98%
Packaging
0.025g
Price
$380
Updated
2021/12/16
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LOFEPRAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Gamonil,E. Merck

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Uses

Lofepramine Hydrochloride is a tricyclic anti-depressent drug. Potent inhibitor of noradenaline uptake.

Definition

ChEBI: Lofepramine hydrochloride is a hydrochloride. It has a role as an antidepressant. It contains a lofepramine.

Manufacturing Process

9.8 parts of 10,11-dihydro-5H-dibenzo[b,f]azepine are dissolved in 10 parts of dry toluene and 3.1 parts of sodium amide are added and the mixture is refluxed and stirred for four hours. A solution of 13.5 parts of 1-(4- chlorophenyl)-2-[(3-chloropropyl)methylamino]ethanone in 20 parts of dry toluene is added dropwise and the mixture is stirred and refluxed for eight hours.
After cooling to room temperature water is carefully added to the reaction mixture and the toluene solution is extracted with water to which hydrochloric acid is added so that the aqueous phase obtains the pH-value of 5. The aqueous extract is discarded and the toluene phase is evaporated to dryness in vacuum. The residue is dissolved in 50 parts of methanol. Hydrogen gas is introduced to give the crystalline hydrochloride 1-(4-chlorophenyl)-2-((3- (10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)methylamino)ethanone; MP: 154°-156°C. The hydrochloride may be removed by adding an equivalent of any base (triethyl amine, sodium hydroxide and so on).

Therapeutic Function

Antidepressant

LOFEPRAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LOFEPRAMINE HYDROCHLORIDE Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
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2123
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Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
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58
Hangzhou ChangCun Biotechnology Co., Ltd.
Tel
0571-; 13567100326
Fax
QQ158848739
Email
158848739@qq.com
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China
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Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9639
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Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
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BOC Sciences
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+1-631-485-4226
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1-631-614-7828
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inquiry@bocsci.com
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United States
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Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
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China
ProdList
44918
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Zhuhai Anzhe Biotechnology Co,Ltd.
Tel
13169972583
Email
513211116@qq.com
Country
China
ProdList
3006
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26786-32-3, LOFEPRAMINE HYDROCHLORIDERelated Search:


  • N-(4-CHLOROBENZOYLMETHYL)-3-(10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPIN-5-YL)-N-METHYLPROPYLAMINE HYDROCHLORIDE
  • LOFEPRAMINE HCL
  • LOFEPRAMINE HYDROCHLORIDE
  • 4’-chloro-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl)methylamino)
  • acetophenone,4’-chloro-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl)m
  • acetophenonehcl
  • clopepraminehydrochloride
  • db-2182
  • f)azepine,5-(3-((p-chlorobenzoylmethyl)-n-methylamino)propyl)-5h-dibenz(
  • iopraminehydrochloride
  • leo640hydrochloride
  • lopraminehydrochloride
  • n-methyl-n-(4’-chlorophenacyl)-3-(10,11-dihydro-5h-dibenzo(b,f)azepin-5-yl)p
  • ropylaminehcl
  • 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethan-1-one monohydrochloride
  • Lofepramine Hydrochloride DISCONTINUED, UNSTABLE, OFFER L469380
  • lofepramine hydrochloride (form A)
  • WHR 2908A
  • WHR-2908A
  • 26786-32-3
  • C26H27ClN2OHCl
  • C26H27ClN2OClH
  • C26H28Cl2N2O