LOFEPRAMINE HYDROCHLORIDE

Product Name: LOFEPRAMINE HYDROCHLORIDE
CAS No.: 26786-32-3
Chemical Name: LOFEPRAMINE HYDROCHLORIDE
Synonyms: db-2182;WHR 2908A;WHR-2908A;ropylaminehcl;LOFEPRAMINE HCL;acetophenonehcl;leo640hydrochloride;iopraminehydrochloride;lopraminehydrochloride;clopepraminehydrochloride
CBNumber: CB4351274
Molecular Formula: C26H28Cl2N2O
Formula Weight: 455.42
MOL File: 26786-32-3.mol

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LOFEPRAMINE HYDROCHLORIDE Property

Melting point:: 152-154°
Flash point:: 9℃
storage temp.: 2-8°C
solubility: DMSO: ~24 mg/mL
form: solid
color: off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22-37-53
Safety Statements: 22-24/25-26-28-36/37/39-38
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 2
RTECS: AM6485000
Toxicity: LD50 in mice, rats (mg/kg): >2500, >1000 orally; 920, >1000 i.p.; >1000, >1000 s.c. (Eriksoo, Rohte)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H290May be corrosive to metals

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006780
Product name: LOFEPRAMINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $779.45
Updated: 2021/12/16

AHH

Product number: MT-53291
Product name: Lofepramine hydrochloride
Purity: 98%
Packaging: 0.025g
Price: $380
Updated: 2021/12/16

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LOFEPRAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Gamonil,E. Merck

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Uses

Lofepramine Hydrochloride is a tricyclic anti-depressent drug. Potent inhibitor of noradenaline uptake.

Definition

ChEBI: Lofepramine hydrochloride is a hydrochloride. It has a role as an antidepressant. It contains a lofepramine.

Manufacturing Process

9.8 parts of 10,11-dihydro-5H-dibenzo[b,f]azepine are dissolved in 10 parts of dry toluene and 3.1 parts of sodium amide are added and the mixture is refluxed and stirred for four hours. A solution of 13.5 parts of 1-(4- chlorophenyl)-2-[(3-chloropropyl)methylamino]ethanone in 20 parts of dry toluene is added dropwise and the mixture is stirred and refluxed for eight hours.
After cooling to room temperature water is carefully added to the reaction mixture and the toluene solution is extracted with water to which hydrochloric acid is added so that the aqueous phase obtains the pH-value of 5. The aqueous extract is discarded and the toluene phase is evaporated to dryness in vacuum. The residue is dissolved in 50 parts of methanol. Hydrogen gas is introduced to give the crystalline hydrochloride 1-(4-chlorophenyl)-2-((3- (10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)methylamino)ethanone; MP: 154°-156°C. The hydrochloride may be removed by adding an equivalent of any base (triethyl amine, sodium hydroxide and so on).

Therapeutic Function

Antidepressant

LOFEPRAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LOFEPRAMINE HYDROCHLORIDE Suppliers

China 18 Germany 1 India 3 Switzerland 1 United Kingdom 4 United States 10 USA 1 Global 38

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26786-32-3, LOFEPRAMINE HYDROCHLORIDERelated Search:

Venlafaxine hydrochloride Duloxetine hydrochloride enteric-coated tablets Imipramine hydrochloride DESIPRAMINE HYDROCHLORIDE LOFEPRAMINE HYDROCHLORIDE LOFEPRAMINE

N-(4-CHLOROBENZOYLMETHYL)-3-(10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPIN-5-YL)-N-METHYLPROPYLAMINE HYDROCHLORIDE

LOFEPRAMINE HCL

LOFEPRAMINE HYDROCHLORIDE

4’-chloro-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl)methylamino)

acetophenone,4’-chloro-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl)m

acetophenonehcl

clopepraminehydrochloride

db-2182

f)azepine,5-(3-((p-chlorobenzoylmethyl)-n-methylamino)propyl)-5h-dibenz(

iopraminehydrochloride

leo640hydrochloride

lopraminehydrochloride

n-methyl-n-(4’-chlorophenacyl)-3-(10,11-dihydro-5h-dibenzo(b,f)azepin-5-yl)p

ropylaminehcl

1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethan-1-one monohydrochloride

Lofepramine Hydrochloride DISCONTINUED, UNSTABLE, OFFER L469380

lofepramine hydrochloride (form A)

WHR 2908A

WHR-2908A

26786-32-3

C26H27ClN2OHCl

C26H27ClN2OClH

C26H28Cl2N2O