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Phentolamine hydrochloride

Product Name
Phentolamine hydrochloride
CAS No.
73-05-2
Chemical Name
Phentolamine hydrochloride
Synonyms
c-7337;phentolaminechloride;Regitine hydrochloride;PHENTOLAMINE HYDROCHLORIDE;Phentolamine Hydrochloride (300 mg);Phentolamine hydrochloride USP/EP/BP;Phentolamine Hydrochloride (1529005);Phentolamine hydrochloride, Non-selective alpha antagonist;2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLINE HYDROCHLORIDE;m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonohydrochloride
CBNumber
CB4358864
Molecular Formula
C17H20ClN3O
Formula Weight
317.81
MOL File
73-05-2.mol
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Phentolamine hydrochloride Property

Melting point:
>230 (dec.)°C
storage temp. 
-20°C Freezer
solubility 
methanol: 10 mg/mL, clear, colorless
form 
powder
color 
white to off-white
Merck 
13,7348
BRN 
3764617
CAS DataBase Reference
73-05-2
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Safety

Hazard Codes 
Xn,C
Risk Statements 
22-34
Safety Statements 
22-24/25-45-36/37/39-27-26
RIDADR 
3249
WGK Germany 
3
RTECS 
SL0701000
F 
3-10
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 in rats (mg/kg): 75 i.v.; 275 s.c.; 1250 orally (Meier)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7547
Product name
Phentolamine hydrochloride
Purity
≥98% (TLC), powder
Packaging
100mg
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
P7547
Product name
Phentolamine hydrochloride
Purity
≥98% (TLC), powder
Packaging
500mg
Price
$164
Updated
2024/03/01
TRC
Product number
P302550
Product name
Phentolamine hydrochloride
Packaging
500mg
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP26895
Product name
Phentolamine hydrochloride
Packaging
250mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FP26895
Product name
Phentolamine hydrochloride
Packaging
500mg
Price
$400
Updated
2021/12/16
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Phentolamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Phentolamine hydrochloride is Tan Solid

Originator

Regitine, Ciba, US ,1952

Uses

Phentolamine Hydrochloride ia an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.

Uses

anesthetic (local); inhibitor of DRG IA/Kv4.2 current

Uses

Phentolamine hydrochloride is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.

Manufacturing Process

199.24 parts of N-(p-methylphenyl)-m'-hydroxyphenylamine and 77.52 parts of 2-chloromethylimidazoline hydrochloride are heated for sixteen hours in an oil bath having a temperature of 150°C, while stirring and introducing a current of nitrogen. The viscous contents of the flask are then cooled to about 100°C, mixed with 400 parts by volume of hot water, and stirred for a short time.
After further cooling to about 60°C, 200 parts by volume of water and 500 parts by volume of ethyl acetate at 60°C are added, and the aqueous layer is separated. The excess of starting material may be recovered from the ethyl acetate.
The aqueous portion is chilled in a cooling chamber at -10°C, whereupon the hydrochloride of 2-[N-(p-methylphenyl)-N-(m'-hydroxyphenyl)-aminomethyl]imidazoline crystallizes. Upon being concentrated and cooled the mother liquor yields a further quantity of the hydrochloride. The combined quantities of hydrochloride are treated with a small quantity of cold water, dried with care, and washed with ethyl acetate. The product is then crystallized from a mixture of alcohol and ethyl acetate, and there is obtained a hydrochloride melting at 239°-240°C.

brand name

Regitine Hydrochloride (Ciba-Geigy).

Therapeutic Function

Adrenergic blocker

Biochem/physiol Actions

α-adrenoceptor antagonist; peripheral vasodilator.

Phentolamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Phentolamine hydrochloride Suppliers

Canada 1 China 47 France 1 Germany 1 India 2 Switzerland 1 United Kingdom 4 United States 17 Global 74
Ambinter
Tel
--
Fax
--
Email
contact@ambinter.com
Country
France
ProdList
1648
Advantage
60
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View Lastest Price from Phentolamine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
PhentolaMine Hydrochloride 73-05-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-11
Dideu Industries Group Limited
Product
Phentolamine hydrochloride 73-05-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-12

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