(S)-(-)-METHYL P-TOLYL SULFOXIDE Property

Melting point:

75-77 °C(lit.)

Boiling point:

282.4±19.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

optical activity

[α]20/D 145°, c = 2 in acetone

BRN 

2324696

Safety

WGK Germany 

3

F 

3-10

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

(S)-(-)-METHYL P-TOLYL SULFOXIDE Chemical Properties,Usage,Production

Uses

(S)-(-)-Methyl p-tolyl sulfoxide can be used as a nucleophilic reagent to synthesize:

• Optically active β-disulfoxides by reacting with arenesulfinic esters via formation of α-sulfinylcarbanion.
• α-substituted N-hydroxylamines by treating with nitrones via preparation of (S)-(-)-methyl p-tolyl sulfoxide anion.
• 2-O-benzyl-3,4-O-isopropylidene-L-erythrose by one-carbon homologation of 2,3-O-isopropylidene-L-glyceraldehyde.