1A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE Property

Melting point:

204-206°C

Boiling point:

390.2±52.0 °C(Predicted)

Density 

1.377±0.06 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

-20°C

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Solid

pka

13.91±0.20(Predicted)

color 

White

Safety

Hazard Codes 

Xn,N,T,F

Risk Statements 

22-36/37/38-51/53-39/23/24/25-23/24/25-11

Safety Statements 

26-36-61-45-36/37-16-7

RIDADR 

2811

WGK Germany 

3

RTECS 

HQ4430000

HazardClass 

6.1(b)

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

1A,10B-DIHYDRO-6H-DIBENZO[B,F]OXIRENO[D]AZEPINE-6-CARBOXAMIDE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A metabolite of Carbamazepine (C175840). Representative lots contained 1-2% carbamazepine by HPLC.

Uses

A metabolite of Carbamazepine (C175840).Representative lots contained 1-2% carbamazepine by HPLC.

Uses

A metabolite of Carbamazepine. Representative lots contained 1-2% carbamazepine by HPLC

Definition

ChEBI: An epoxide and metabolite of carbamazepine.

General Description

Carbamazepine-10,11-epoxide is the primary, active metabolite in both urine and serum of carbamazepine, an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder as well as trigeminal neuralgia. Potential toxicity of the epoxide metabolite requires regular therapeutic drug monitoring by LC or LC/MS for patients taking carbamazepine.

Biochem/physiol Actions

First metabolite of carbamazepine