CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
- Product Name
- CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
- CAS No.
- 17191-44-5
- Chemical Name
- CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
- Synonyms
- Z-CLE-OH;Z-AC5C-OH;Z-NH(1)CPEN-OH;Cbz-Cycloleucine;Cbz-Cyclolencine;1-(Cbz-amino)cycL;N-Cbz-cycloleucine;RARECHEM AL CF 0201;N-ALPHA-CARBOBENZOXY-CYCLOLEUCINE;1-(Cbz-aMino)cyclopentanecarboxylic Acid
- CBNumber
- CB4365295
- Molecular Formula
- C14H17NO4
- Formula Weight
- 263.29
- MOL File
- 17191-44-5.mol
CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID Property
- Melting point:
- 95-98 °C
- Boiling point:
- 468.2±34.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.12±0.20(Predicted)
Safety
- HS Code
- 2917399590
N-Bromosuccinimide Price
- Product number
- B194055
- Product name
- 1-(Benzyloxycarbonylamino)cyclopentanecarboxylicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC148135
- Product name
- Cbz-1-amino-1-cyclopentanecarboxylicacid
- Packaging
- 50mg
- Price
- $83
- Updated
- 2021/12/16
- Product number
- FC148135
- Product name
- Cbz-1-amino-1-cyclopentanecarboxylicacid
- Packaging
- 100mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- 4658-1-0W
- Product name
- 1-(Cbz-Amino)cyclopentanecarboxylic acid
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- FC148135
- Product name
- Cbz-1-amino-1-cyclopentanecarboxylicacid
- Packaging
- 250mg
- Price
- $287.5
- Updated
- 2021/12/16
CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
501-53-1
52-52-8
17191-44-5
To a 1:1 dioxane/water (60 mL) solution of 1-aminocyclopentanecarboxylic acid (3.0 g, 23.2 mmol) was slowly added sodium carbonate (Na2CO3, 12.3 g, 116 mmol), followed by dropwise addition of benzyl chloroformate (3.6 mL, 25.5 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the pH was carefully adjusted to 2 with 1 M hydrochloric acid (HCl) and then extracted with ethyl acetate (EtOAc, 3 × 30 mL). The organic phases were combined, washed with saturated saline (30 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give a light yellow oily crude product. The crude product was analyzed by LCMS and NMR as a mixture of Cbz-cycloleucine and its corresponding benzyl ester. The crude product was dissolved in 1:1 tetrahydrofuran/water (THF/H2O, 60 mL) and lithium hydroxide (LiOH, 2.67 g, 116 mmol) was added. The mixture was stirred overnight at room temperature and then washed with ether (Et2O, 3 × 30 mL), then acidified with 1 M HCl to pH = 2 and finally extracted with EtOAc (3 × 30 mL). The organic phases were combined, washed with saturated saline (30 mL), dried over MgSO4, filtered and concentrated under reduced pressure to give Cbz-cycloleucine (4.76 g, 78% yield).LCMS: m/z 264 [M + H]+.
References
[1] Organic Process Research and Development, 1998, vol. 2, # 4, p. 238 - 244
[2] Patent: US2010/317865, 2010, A1. Location in patent: Page/Page column 14; 15
[3] Patent: WO2009/106844, 2009, A1. Location in patent: Page/Page column 39
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2001, vol. 40, # 1, p. 70 - 74
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 2, p. 533 - 548
CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID manufacturers
- Product
- Cbz-Cyclolencine 17191-44-5
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID 17191-44-5
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24
- Product
- CBZ-1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID 17191-44-5
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24