ChemicalBook > CAS DataBase List > Cynaroside

Cynaroside

Effects

Product Name: Cynaroside
CAS No.: 5373-11-5
Chemical Name: Cynaroside
Synonyms: LUTEOLIN-7-O-GLUCOSIDE;luteoloside;PETUNIDIN;LUTEOLIN-7-GLUCOSIDE;Galuteolin;cinaroside;glucoluteolin;Luteolin 7-O-β-D-glucopyranoside;4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(.beta.-D-glucopyranosyloxy)-5-hydroxy-;Cyroside
CBNumber: CB4369516
Molecular Formula: C21H20O11
Formula Weight: 448.38
MOL File: 5373-11-5.mol

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Cynaroside Property

Melting point:: 256～258℃
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
Boiling point:: 838.1±65.0 °C(Predicted)
Density: 1.713±0.06 g/cm3(Predicted)
pka: 6.10±0.40(Predicted)
form: Solid
color: Yellow to Very Dark Yellow
Stability:: Hygroscopic
InChIKey: PEFNSGRTCBGNAN-QNDFHXLGSA-N
SMILES: C1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)=C2)C(=O)C=1 |&1:17,18,20,22,24,r|
LogP: -0.090 (est)
CAS DataBase Reference: 5373-11-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
RTECS: DJ3009400
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89724
Product name: Luteolin 7-glucoside
Purity: phyproof? Reference Substance
Packaging: 20mg
Price: $368
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1370837
Product name: Luteolin 7-O-Glucoside
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 30mg
Price: $586
Updated: 2025/07/31

Sigma-Aldrich

Product number: 03600585
Product name: Luteolin 7-glucoside
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $485
Updated: 2025/07/31

Cayman Chemical

Product number: 25141
Product name: Luteoloside
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 25141
Product name: Luteoloside
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

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Cynaroside Chemical Properties,Usage,Production

Effects

Luteolin has a strong bactericidal effect on the respiratory tract, and it is the main active ingredient in the treatment of bronchitis in Qinglan, a unique medicinal material in Xinjiang. Lowers the role of cholesterol in atherosclerosis and enhances capillary relaxation.

Description

Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC₅₀ = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC₅₀ = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .

Chemical Properties

Off-white powder

Uses

Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.

Definition

ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

in vivo

Cynaroside (i.p.; 5mg/kg) reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105^[2].

Animal Model:	Mice model of sepsis^[2]
Dosage:	5mg/kg
Administration:	Cynaroside (i.p.; 5mg/kg)
Result:	Inhibited PKM2 dimer formation in liver of septic mice.

References

[1] ZHANTU LIU. Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein.[J]. Phytotherapy Research, 2018, 32 6: 1126-1134. DOI: 10.1002/ptr.6053
[2] ZEYU CAO. Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro.[J]. PLoS ONE, 2016, 11 1: e0148693. DOI: 10.1371/journal.pone.0148693
[3] SHAO-HUA FAN. Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome.[J]. PLoS ONE, 2014: e89961. DOI: 10.1371/journal.pone.0089961
[4] R PALOMBO. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model[J]. Cell Death & Disease, 2016, 7 8: e2344-e2344. DOI: 10.1038/cddis.2016.201

Cynaroside Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cynaroside manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Cynaroside 5373-11-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Hebei Yanxi Chemical Co., Ltd.

Product: Cynaroside 5373-11-5
Price: US $30.00-10.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-11-15

Shanghai Standard Technology Co., Ltd.

Product: Cynaroside 5373-11-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-18

5373-11-5, CynarosideRelated Search:

Luteolin CHLOROPHOSPHONAZO III BETA-GLUCOSIDASE AMYLOGLUCOSIDASE Taxifolin luteolin-7-glucuronide Luteolin-3'-D-glucuronide alkyl polyglucoside Ranolazine PETUNIDIN CHLORIDE Diosmin petunidin-3-O-glu,PETUNIDIN3-O-GLUCOSIDE ALPHA-BOSWELLIC ACID QUERCETIN-7-O-GLUCOSIDE LUTEOLIN-7,3'-DI-O-DIGLUCURONIDE nepitrin OCTYL GLUCOSIDE linariifolioside

LUTEOLIN-7-O-GLUCOSIDE 98+%

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(.beta.-D-glucopyranosyloxy)-5-hydroxy-

luteolin7-o-glucopyranoside

luteoloside

CYNAROSIDE

LUTEOLIN-7-GLUCOSIDE

LUTEOLIN-7-O-GLUCOSIDE

LUTEOLIN-7-O-GLUCOSIDE WITH HPLC

7-β-D-Glucosylluteolin

Nephrocizin

Nephrocizine

Luteoloside，Cynaroside，Galuteolin，Glucoluteolin

Luteolin 7-O-β-D-glucopyranoside

Luteolin 7-β-D-glucopyranoside

Luteolin 7-b-glucoside

lCynaroside

Daphneflavonoloside

Flavopurposide

Galuteolin

LUTEOLIN-7-GLUCOSIDE hplc

2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

Luteolin 7-O-D-glucoside

Luteolin-7-O-D-glucopyranoside, 98%, from Gentiana macrophylla

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-5-hydroxy-

GLUCOLUTEOLIN; LUTEOLOSIDE; CINAROSIDE; LUTEOLIN 7-GLUCOSIDE;LUTEOLIN 7-O-Β-D-GLUCOSIDE

LUTEOLIN-7-O-GLUCOSIDE(P)

Luteolin 7-beta-glucoside

Luteolin-7-O-D-glucopyranoside, froM Gentiana Macrophylla

Cynaroside Luteolin 7-O-D-glucoside

4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-7-(b-D-glucopyranosyloxy)-5-hydroxy-

luteolin 7-O-beta-D-glucoside

Luteolin-7-O-β-D-glucopyranoside, 98%, from Gentiana macrophylla Pall.

PETUNIDIN

2-(3,4-dihydroxyphenyl)-7-(beta-d-glucopyranosyloxy)-5-hydroxy-4h-1-benzopyr

4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-7-(beta-d-glucopyranosyloxy)-5-h

7-glucoluteolin

7-glucosylluteolin

cinaroside

glucoluteolin

luteolin7-monoglucoside

2-(3,4-dihydroxyphenyl)-5-hydroxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

luteolin7-O-β-D-glucoside

Cynaroside USP/EP/BP

Cynaroside (Luteolin 7-glucoside)

Luteoloside (Cynaroside)

Luteoloside Luteolin 7-glucoside

Luteolin 7-glucoside-RM

Luteolin-7-O-Glucoside(Cynaroside)(AS)

Cynaroside, 10 mM in DMSO

Luteolin 7-<i>O</i>-β-<sc>D</sc>-glucoside

Luteolin 7-glucoside [Storage:2℃±4℃, Purity:98%min.

Luteolin-7-O-glucoside 1000 μg/mL in Ethanol

Cyroside

Luteolin-7-O-glucoside /Cynaroside

5373-11-5

5375-11-5

1268-79-8

chemical reagent