3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN

Product Name: 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN
CAS No.: 6174-86-3
Chemical Name: 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN
Synonyms: Nsc24924;Aids124364;chlorferron;Chlorferone;Aids-124364;AKOS BBS-00008033;Coumaphos alcohol metabolite;3-CHLORO-4-METHYLUMBELLIFERONE;3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN;7-Hydroxy-4-methyl-3-chlorocoumarin
CBNumber: CB4371760
Molecular Formula: C10H7ClO3
Formula Weight: 210.61
MOL File: 6174-86-3.mol

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3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN Property

Melting point:: 240-244 °C (lit.)
Boiling point:: 405.8±45.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 7.43±0.20(Predicted)
form: Powder
color: White to off-white
λmax: 332nm(EtOH)(lit.)
CAS DataBase Reference: 6174-86-3(CAS DataBase Reference)
EPA Substance Registry System: 2H-1-Benzopyran-2-one, 3-chloro-7-hydroxy-4-methyl- (6174-86-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
TSCA: Yes
HS Code: 29329900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 640611
Product name: 3-Chloro-7-hydroxy-4-methylcoumarin
Purity: 97%
Packaging: 1g
Price: $65.1
Updated: 2025/07/31

TCI Chemical

Product number: C3098
Product name: 3-Chloro-7-hydroxy-4-methylcoumarin
Purity: >98.0%(T)
Packaging: 1g
Price: $122
Updated: 2025/07/31

TCI Chemical

Product number: C3098
Product name: 3-Chloro-7-hydroxy-4-methylcoumarin
Purity: >98.0%(T)
Packaging: 5g
Price: $442
Updated: 2025/07/31

Sigma-Aldrich

Product number: 640611
Product name: 3-Chloro-7-hydroxy-4-methylcoumarin
Purity: 97%
Packaging: 5g
Price: $130
Updated: 2025/07/31

TRC

Product number: C327092
Product name: Chlorferon-13C6
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

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3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN Chemical Properties,Usage,Production

Uses

Labelled Chlorferon is has α-Glucosidase inhibitory antihyperglycemic activity of substituted chromenone derivatives. Also used in the synthesis of fluorogenic substrates for the detection of bacterial β-Galactosidase.

Definition

ChEBI: Chlorferron is an organochlorine compound. It is functionally related to a 4-methylumbelliferone.

Synthesis

609-15-4

108-46-3

6174-86-3

GENERAL STEPS: Resorcinol (2.0 g, 18.2 mmol) was dissolved in dioxane and the solution was cooled to 0 °C. Concentrated sulfuric acid (0.5 mL) was added slowly and dropwise at 25 °C. Subsequently, ethyl 2-chloroacetoacetate (2.8 g, 21.8 mmol) was added and the reaction mixture was heated to 60 °C and maintained at this temperature for 4 hours. After completion of the reaction, the mixture was poured into cold water, the precipitate was collected by filtration and dried under reduced pressure. Finally, the product was purified by recrystallization from methanol to give 3-chloro-7-hydroxy-4-methylcoumarin (6a) as white needle-like crystals.

References

[1] Chemistry - A European Journal, 2012, vol. 18, # 32, p. 9901 - 9910
[2] Synthesis, 2006, # 11, p. 1895 - 1897
[3] Monatshefte fur Chemie, 2008, vol. 139, # 7, p. 805 - 808
[4] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 153 - 165
[5] Tetrahedron Letters, 2006, vol. 47, # 19, p. 3279 - 3281

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN Suppliers

Americas 1 China 85 Europe 1 Germany 4 India 7 Japan 1 Switzerland 2 The Netherlands 1 United Kingdom 8 United States 15 Global 125

J & K SCIENTIFIC LTD.

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TCI (Shanghai) Development Co., Ltd.

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Thermo Fisher Scientific

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View Lastest Price from 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN manufacturers

Honest Joy Holdings Limited

Product: 3-Chloro-4-methyl-7-hydroxycoumarin 6174-86-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.3%
Supply Ability: 100 tons
Release date: 2022-01-14

Dideu Industries Group Limited

Product: 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN 6174-86-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

Career Henan Chemical Co

Product: 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN 6174-86-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-09

6174-86-3, 3-CHLORO-7-HYDROXY-4-METHYLCOUMARINRelated Search:

Dimethyl sulfate Rhamnosylvitexin COUMAPHOS-OXON 4-Methylcumarin Coumarin 3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN Phosphorothioic acid, O,O-diethyl ester, O-ester with 3-chloro-7-hydroxy-4-methylcoumarin 7-(CARBOXYMETHOXY)-3-CHLORO-4-METHYLCOUMARIN 6-CHLORO-4-HYDROXY-7-METHYLCOUMARIN 6-CHLORO-7-HYDROXY-4-METHYLCOUMARIN haloxon DIMETHYL-PHOSPHORAMIDIC ACID 3-CHLORO-4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER ETHYL ESTER 3-CHLORO-7-DIMETHOXYTHIOPHOSPHORYLOXY-4-METHYL COURMAIN CYCLOHEXYL-METHYL-PHOSPHINIC ACID 3-CHLORO-4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER 3-CHLORO-7,8-DIHYDROXY-4-METHYL-2H-CHROMEN-2-ONE PHOSPHORIC ACID 3-CHLORO-4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER DIMETHYL ESTER 3-CHLORO-6,7-DIHYDROXY-4-METHYL-2H-CHROMEN-2-ONE METHYL-PHOSPHONIC ACID 3-CHLORO-4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER ETHYL ESTER

3-CHLORO-4-METHYLUMBELLIFERONE

3-CHLORO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN

3-chloro-7-hydroxy-4-methyl-2h-1-benzopyran-2-on

3-chloro-7-hydroxy-4-methyl-2-benzopyrone

3-CHLORO-7-HYDROXY-4-METHYL-2H-1-BENZOPYRAN-2-ONE

3-Chloro-4-methyl-7-hydroxycoumarine

AKOS BBS-00008033

chlorferron

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN 98%

3-Chloro-4-methyl-7-hydroxy-2H-1-benzopyran-2-one

Chlorferone

3-Chloro-4-methyl-7-hydroxycoumarin,96%

2H-1-Benzopyran-2-one, 3-chloro-7-hydroxy-4-methyl-

7-Hydroxy-4-methyl-3-chlorocoumarin

Aids124364

Aids-124364

Coumarin, 3-chloro-7-hydroxy-4-methyl-

Nsc24924

3-Chloro-7-hydroxy-4-methylcoumarin,3-Chloro-4-methylumbelliferone

3-chloro-7-hydroxy-4-methyl-1-benzopyran-2-one

Coumaphos alcohol metabolite

3-CHLORO-7-HYDROXY-4-METHYLCOUMARIN ISO 9001：2015 REACH

6174-86-3

Building Blocks

Heterocyclic Building Blocks

Coumarins