Eliprodil
- Product Name
- Eliprodil
- CAS No.
- 119431-25-3
- Chemical Name
- Eliprodil
- Synonyms
- ELIPRODIL;SL 820715;Eliprodil, 10 mM in DMSO;1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-;ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL;SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
- CBNumber
- CB4373759
- Molecular Formula
- C20H23ClFNO
- Formula Weight
- 347.85
- MOL File
- 119431-25-3.mol
Eliprodil Property
- Boiling point:
- 474.1±35.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ~17 mg/mL
- form
- solid
- pka
- 13.99±0.20(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E2031
- Product name
- Eliprodil
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $135.8
- Updated
- 2025/07/31
- Product number
- 5.04539
- Product name
- Eliprodil - CAS 119431-25-3 - Calbiochem
- Packaging
- 10mg
- Price
- $92.5
- Updated
- 2025/07/31
- Product number
- E2031
- Product name
- Eliprodil
- Purity
- ≥98% (HPLC), powder
- Packaging
- 50mg
- Price
- $660
- Updated
- 2023/01/07
- Product number
- 18398
- Product name
- Eliprodil
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 18398
- Product name
- Eliprodil
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2023/01/06
Eliprodil Chemical Properties,Usage,Production
Description
N-
Uses
Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.
Definition
ChEBI: Eliprodil is a racemate comprising equimolar amounts of (R)- and (S)-eliprodil. It is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and an anti-ischaemic agent that exhibits neuroprotective properties. It has a role as a geroprotector, a NMDA receptor antagonist, a neuroprotective agent and a calcium channel blocker. It contains a (R)-eliprodil and a (S)-eliprodil.
Biological Activity
Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.
Biological Activity
Eliprodil (SL-820715) is a non-competitive, NR2B-selective NMDA antagonist with IC50 of 1 μM. Its IC50 is greater than 100 μM for receptors containing NR2A and NR2C.
storage
+4°C (desiccate)
References
[1] CATHERINE P. BATH. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia[J]. European journal of pharmacology, 1996, 299 1: Pages 103-112. DOI: 10.1016/0014-2999(95)00846-2
[2] E R WHITTEMORE R M W V I Ilyin. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 282 1: 326-338.
[3] SARAH GRIMWOOD. Characterisation of N-Methyl-D-Aspartate Receptor-Specific [3H]Ifenprodil Binding to Recombinant Human NR1a/NR2B Receptors Compared with Native Receptors in Rodent Brain Membranes[J]. Journal of Neurochemistry, 2008, 75 6: 2455-2463. DOI: 10.1046/j.1471-4159.2000.0752455.x
[4] CSABA LENGYEL. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk[J]. British Journal of Pharmacology, 2009, 143 1: 152-158. DOI: 10.1038/sj.bjp.0705901
Eliprodil Preparation Products And Raw materials
Raw materials
Preparation Products
Eliprodil Suppliers
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View Lastest Price from Eliprodil manufacturers
- Product
- ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL 119431-25-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31