Eliprodil

ChemicalBook > CAS DataBase List > Eliprodil

Product Name: Eliprodil
CAS No.: 119431-25-3
Chemical Name: Eliprodil
Synonyms: ELIPRODIL;SL 820715;1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol;α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-;ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
CBNumber: CB4373759
Molecular Formula: C20H23ClFNO
Formula Weight: 347.85
MOL File: 119431-25-3.mol

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Eliprodil Property

Boiling point:: 474.1±35.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ~17 mg/mL
form: solid
pka: 13.99±0.20(Predicted)
color: white

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E2031
Product name: Eliprodil
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $189
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.04539
Product name: Eliprodil - CAS 119431-25-3 - Calbiochem
Packaging: 10mg
Price: $90
Updated: 2024/03/01

Sigma-Aldrich

Product number: E2031
Product name: Eliprodil
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $660
Updated: 2023/01/07

Cayman Chemical

Product number: 18398
Product name: Eliprodil
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 18398
Product name: Eliprodil
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2023/01/06

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Eliprodil Chemical Properties,Usage,Production

Description

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC₅₀ = 1 μM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds σ₁ and σ₂ sites (K_is = 0.013 and 0.63 μM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.

Uses

Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.

Definition

ChEBI: Eliprodil is a racemate comprising equimolar amounts of (R)- and (S)-eliprodil. It is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and an anti-ischaemic agent that exhibits neuroprotective properties. It has a role as a geroprotector, a NMDA receptor antagonist, a neuroprotective agent and a calcium channel blocker. It contains a (R)-eliprodil and a (S)-eliprodil.

Biological Activity

Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.

Biological Activity

Eliprodil (SL-820715) is a non-competitive, NR2B-selective NMDA antagonist with IC50 of 1 μM. Its IC50 is greater than 100 μM for receptors containing NR2A and NR2C.

storage

+4°C (desiccate)

Eliprodil Preparation Products And Raw materials

Raw materials

Preparation Products

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Eliprodil Suppliers

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View Lastest Price from Eliprodil manufacturers

Career Henan Chemical Co

Product: ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL 119431-25-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

119431-25-3, EliprodilRelated Search:

7-Hydroxyisoflavone (7β,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid γ-Lactone Methyl Ester Serotonin hydrochloride (R)-Eliprodil (S)-Eliprodil 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 4-(4-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE 4-(4'-Fluorobenzyl)piperidine Eliprodil

SL 820715

ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL

ELIPRODIL

α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol

SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol

(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol

1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol

1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-

α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol

1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol

(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol

119431-25-3

C20H23ClFNO

Cell Biology

BioChemical

Cell Signaling and Neuroscience

Ionotropic Glutamate Receptor Modulators

Ion Channels

Ligand-Gated Ion Channels

Inhibitors

Glutamate receptor

Neuroprotective agent.