AFC

Product Name: AFC
CAS No.: 135304-07-3
Chemical Name: AFC
Synonyms: AFC;AFC USP/EP/BP;AC-CYS(FARNESYL)-OH;Ac-L-Cys(Farnesyl)-OH;AC-CYSTEINE(FARNESYL)-OH;N-Acetyl-L-farnesylcysteine;n-acetyl-s-farnesylcysteine;ACETYL-S-FARNESYL-L-CYSTEINE;N-ACETYL-S-FARNESYL-L-CYSTEINE;N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
CBNumber: CB4379892
Molecular Formula: C20H33NO3S
Formula Weight: 367.55
MOL File: 135304-07-3.mol

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AFC Property

Boiling point:: 566.1±50.0 °C(Predicted)
Density: 1.038±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
pka: 3.31±0.10(Predicted)
form: Pale yellow oil.
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP: 5.860 (est)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 25mg
Price: $305
Updated: 2024/03/01

TRC

Product number: A765560
Product name: Arazine
Packaging: 10mg
Price: $80
Updated: 2021/12/16

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AFC Chemical Properties,Usage,Production

Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Chemical Properties

Yellow-red oil

Uses

Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.

Definition

ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.

References

1) Volker?et al.?(1991),?Effects of farnesylcyteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem.?266?21515 2) Xu?et al.?(1996),?Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol.?50?1495 3) Rosado and Sage (2000),?Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J.?347?183 4) Gordon?et al.?(2008),?Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol.?128?643 5) Adhami?et al.?(2012),?N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells;?Exp. Dermatol.?21?700

AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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AFC Suppliers

China 41 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 23 USA 1 Global 71

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-66110311 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15527
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

135304-07-3, AFCRelated Search:

AC-CYS(FARNESYL)-OME Z-ARG-ARG-AFC Z-IETD-AFC,Z-ILE-GLU-THR-ASP-AFC AFC FA-CYS(FARNESYL)-OH N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE Z-ASP-GLN-MET-ASP-AFC,Z-DQMD-AFC Z-VAL-LYS-LYS-ARG-AFC,Z-VKKR-AFC Z-RGFFL-AFC HCL,Z-ARG-GLY-PHE-PHE-LEU-AFC HCL Z-ALA-AFC Z-MET-AFC Z-LYS-AFC Z-GGR-AFC,Z-GLY-GLY-ARG-AFC Z-ALA-ALA-ASP-AFC Z-VAL-GLU-ILE-ASP-AFC,Z-VEID-AFC VLR-AFC VLK-AFC Z-GLY-PRO-ARG-AFC,Z-GRP-AFC

AFC

AC-CYSTEINE(FARNESYL)-OH

AC-CYS(FARNESYL)-OH

ACETYL-S-FARNESYL-L-CYSTEINE

N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE

N-ACETYL-S-FARNESYL-L-CYSTEINE

N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE

n-acetyl-s-farnesylcysteine

N-Acetyl-S-farnesyl-L-cysteine (AFC)

N-Acetyl-L-farnesylcysteine

N-Acetyl-S-trans,trans-farnesyl-L-cysteine

Acetyl-S-farnesyl-L-cysteine≥ 99% (TLC)

Ac-L-Cys(Farnesyl)-OH

N-Acetyl-S-(3,7,11-trimethyl-2ε,6ε,10-dodecatrienyl)-L-cysteine

L-Cysteine,N-acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-

(R)-2-acetamido-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio) propanoic acid

AFC USP/EP/BP

L-Cysteine,N-acetyl-S-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (E,E)-

N-Acetyl-S-farnesyl-L-cysteine (AFC), Specific S-farnesylcysteine methyl transferase inhibitor

135304-07-3

163479-47-3

C20H33NO3S