ChemicalBook > CAS DataBase List > AFC

AFC

Product Name: AFC
CAS No.: 135304-07-3
Chemical Name: AFC
Synonyms: AFC;AFC USP/EP/BP;AC-CYS(FARNESYL)-OH;Ac-L-Cys(Farnesyl)-OH;AC-CYSTEINE(FARNESYL)-OH;N-Acetyl-L-farnesylcysteine;n-acetyl-s-farnesylcysteine;ACETYL-S-FARNESYL-L-CYSTEINE;N-ACETYL-S-FARNESYL-L-CYSTEINE;N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
CBNumber: CB4379892
Molecular Formula: C20H33NO3S
Formula Weight: 367.55
MOL File: 135304-07-3.mol

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AFC Property

Boiling point:: 566.1±50.0 °C(Predicted)
Density: 1.038±0.06 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
pka: 3.31±0.10(Predicted)
form: Pale yellow oil.
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP: 5.860 (est)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 63270
Product name: N-acetyl-S-farnesyl-L-Cysteine
Purity: ≥98%
Packaging: 25mg
Price: $305
Updated: 2024/03/01

TRC

Product number: A765560
Product name: Arazine
Packaging: 10mg
Price: $80
Updated: 2021/12/16

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AFC Chemical Properties,Usage,Production

Description

N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

Chemical Properties

Yellow-red oil

Uses

Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras.

Definition

ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid.

in vivo

Arazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED₅₀) of 55±12?μg/20?μl^[1].

Animal Model:	TPA-induced ear acute inflammation in mouse^[1]
Dosage:	2000?μg/20?μl
Administration:	2000?μg/20?μl; Applied on ear
Result:	Inhibited ear edema, as measured by ear weight.

References

[1] C VOLKER. Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction.[J]. The Journal of Biological Chemistry, 1991, 266 32: 21515-21522.
[2] Y XU. Inhibition of capacitative Ca2+ entry into cells by farnesylcysteine analogs.[J]. Molecular Pharmacology, 1996, 50 6: 1495-1501.
[3] J. ROSADO S S. Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton.[J]. The Ukrainian Biochemical Journal, 2000, 13 1: 183-192. DOI:10.1042/bj3470183
[4] JOEL S. GORDON . Topical N-acetyl-S-farnesyl-L-cysteine Inhibits Mouse Skin Inflammation, and Unlike Dexamethasone, its Effects Are Restricted to the Application Site[J]. Journal of Investigative Dermatology, 2008, 128 3: Pages 643-654. DOI:10.1038/sj.jid.5701061
[5] KATAYUN ADHAMI. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells[J]. Experimental Dermatology, 2012, 21 9: 700-705. DOI:10.1111/j.1600-0625.2012.01562.x

AFC Preparation Products And Raw materials

Raw materials

Preparation Products

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AFC Suppliers

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135304-07-3, AFCRelated Search:

AC-CYS(FARNESYL)-OME Z-ARG-ARG-AFC Z-IETD-AFC,Z-ILE-GLU-THR-ASP-AFC AFC FA-CYS(FARNESYL)-OH N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE Z-ASP-GLN-MET-ASP-AFC,Z-DQMD-AFC Z-VAL-LYS-LYS-ARG-AFC,Z-VKKR-AFC Z-RGFFL-AFC HCL,Z-ARG-GLY-PHE-PHE-LEU-AFC HCL Z-ALA-AFC Z-MET-AFC Z-LYS-AFC Z-GGR-AFC,Z-GLY-GLY-ARG-AFC Z-ALA-ALA-ASP-AFC Z-VAL-GLU-ILE-ASP-AFC,Z-VEID-AFC VLR-AFC VLK-AFC Z-GLY-PRO-ARG-AFC,Z-GRP-AFC

AFC

AC-CYSTEINE(FARNESYL)-OH

AC-CYS(FARNESYL)-OH

ACETYL-S-FARNESYL-L-CYSTEINE

N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE

N-ACETYL-S-FARNESYL-L-CYSTEINE

N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE

n-acetyl-s-farnesylcysteine

N-Acetyl-S-farnesyl-L-cysteine (AFC)

N-Acetyl-L-farnesylcysteine

N-Acetyl-S-trans,trans-farnesyl-L-cysteine

Acetyl-S-farnesyl-L-cysteine≥ 99% (TLC)

Ac-L-Cys(Farnesyl)-OH

N-Acetyl-S-(3,7,11-trimethyl-2ε,6ε,10-dodecatrienyl)-L-cysteine

L-Cysteine,N-acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-

(R)-2-acetamido-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio) propanoic acid

AFC USP/EP/BP

L-Cysteine,N-acetyl-S-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (E,E)-

N-Acetyl-S-farnesyl-L-cysteine (AFC), Specific S-farnesylcysteine methyl transferase inhibitor

135304-07-3

163479-47-3

C20H33NO3S