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DOLASTATIN 15

Product Name
DOLASTATIN 15
CAS No.
123884-00-4
Chemical Name
DOLASTATIN 15
Synonyms
DLS 15;Nsc 617668;DOLASTATIN 15;(5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE;(5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one;(5S)-1-[(2S)-O-(N,N-DIMETHYL-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE;Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline;L-Proline, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester;L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-;L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
CBNumber
CB4385736
Molecular Formula
C45H68N6O9
Formula Weight
837.06
MOL File
123884-00-4.mol
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DOLASTATIN 15 Property

Boiling point:
954.0±65.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Methanol: soluble
pka
13.88±0.46(Predicted)
form 
White solid.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30144
Product name
Dolastatin 15
Packaging
1mg
Price
$255
Updated
2024/03/01
TRC
Product number
D528508
Product name
Dolastatin 15
Packaging
1mg
Price
$170
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD110329
Product name
Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
Packaging
1mg
Price
$148
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD110329
Product name
Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
Packaging
2mg
Price
$257
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008286
Product name
DOLASTATIN 15
Purity
95.00%
Packaging
1MG
Price
$365.4
Updated
2021/12/16
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DOLASTATIN 15 Chemical Properties,Usage,Production

Uses

Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation.

in vivo

Dolastatin 15 conjugates to Trastuzumab via lysine residues at the drug C-terminus using a non-cleavable linker (Trastuzumab-amide-C-term-Dol15) produced target-dependent growth inhibition of cells endogenously expressing high HER2 levels (i.e., SK-BR-3, SK-OV-3) in vitro. This ADC was effective at varying doses (i.e., 10 and 20 mg/kg) in the SK-OV-3 human ovarian cancer xenograft[3].

IC 50

Auristatin

DOLASTATIN 15 Preparation Products And Raw materials

Raw materials

Preparation Products

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DOLASTATIN 15 Suppliers

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123884-00-4, DOLASTATIN 15Related Search:

NOCODAZOLE MYOSEVERIN N-ACETYL-ALA-ALA-ALA METHYL ESTER Bis(2-dimethylaminoethyl) ether 4-METHOXY-3-PYRROLIN-2-ONE 2-((2-(2-(DIMETHYLAMINO)ETHOXY)ETHYL) METHYLAMINO)ETHANOL, 97 N-(2-HYDROXYETHYL)LACTAMIDE (S)-(-)-1-ETHYL-2-PYRROLIDINECARBOXYLIC ACID ETHYL ESTER N-N-bis(2-hydroxyethyl)formamide H-GLY-PRO-PRO-OH AC-PRO-OME (2S,2'S)-(-)-2-HYDROXYMETHYL-1-[(1-METHYLPYRROLIDIN-2-YL)-METHYL]-PYRROLIDINE DOLASTATIN 15 N-[1-(AMINOMETHYL)-2-METHYLPROPYL]-N,N-DIMETHYLAMINE METHYL 1-ETHYLPYRROLIDINE-2-CARBOXYLATE H-VAL-PRO-PRO-OH AC-ALA-ALA-ALA-ALA-OME H-PRO-OIPR

  • Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
  • DOLASTATIN 15
  • (5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one
  • L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
  • L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
  • Nsc 617668
  • (5S)-1-[(2S)-O-(N,N-DIMETHYL-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
  • (5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
  • DLS 15
  • L-Proline, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester
  • 123884-00-4
  • C45H68N6O9
  • Microtobule Inhibitors
  • Cytoskeleton and Extracellular Matrix
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical