(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID

Product Name: (S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID
CAS No.: 389888-02-2
Chemical Name: (S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID
Synonyms: (S)-CPW 399;(2S)-2-amino-3-(2,4-dioxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl)propanoic acid;(S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoicacid;(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID;1H-Cyclopentapyrimidine-1-propanoic acid, α-amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-, (αS)-
CBNumber: CB4388111
Molecular Formula: C10H13N3O4
Formula Weight: 239.23
MOL File: 389888-02-2.mol

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(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Property

Melting point:: >163°C (dec.)
storage temp.: Desiccate at -20°C
solubility: Aqueous Acid (Slightly, Heated, Sonicated), DMSO (Slightly)
form: Solid
color: Pale Brown to Brown
Water Solubility: Soluble to 50 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C781478
Product name: (S)-CPW399
Packaging: 10mg
Price: $165
Updated: 2021/12/16

TRC

Product number: C781478
Product name: (S)-CPW399
Packaging: 50mg
Price: $765
Updated: 2021/12/16

ApexBio Technology

Product number: B6781
Product name: (S)-CPW399
Packaging: 50mg
Price: $1362
Updated: 2021/12/16

ApexBio Technology

Product number: B6781
Product name: (S)-CPW399
Packaging: 10mg
Price: $322
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009819
Product name: (S)-CPW 399
Purity: 95.00%
Packaging: 5MG
Price: $497.52
Updated: 2021/12/16

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(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Chemical Properties,Usage,Production

Uses

(S)-CPW 399 is a subtype-selective weakly desensitising AMPA agonist.

Biological Activity

Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (K i values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Exhibits potent agonist activity at GluR1 and GluR2 subunit-containing AMPA receptors (EC 50 values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro .

References

[1]. campiani g, morelli e, nacci v, et al. characterization of the 1h-cyclopentapyrimidine-2,4(1h,3h)-dione derivative (s)-cpw399 as a novel, potent, and subtype-selective ampa receptor full agonist with partial desensitization properties. j med chem, 2001, 44(26): 4501-4504.
[2]. sinclair c, reavy h, grieve a, et al. inherent desensitisation-preventing properties of a novel, subtype-selective ampa receptor agonist, (s)-cpw 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. neurochem int, 2003, 42(6): 499-510.
[3]. salonen v, kallinen s, lopez-picon fr, et al. ampa/kainate receptor-mediated up-regulation of gabaa receptor delta subunit mrna expression in cultured rat cerebellar granule cells is dependent on nmda receptor activation. brain res, 2006, 1087(1): 33-40.
[4]. butini s, pickering ds, morelli e, et al. 1h-cyclopentapyrimidine-2,4(1h,3h)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and selective iglur5 modulators. j med chem, 2008, 51(20): 6614-6618.

(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Suppliers

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389888-02-2, (S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACIDRelated Search:

2-AMINO-3-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid (S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Albizziin S(-)-ALPHA-AMINO-3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID

(S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoicacid

(2S)-2-amino-3-(2,4-dioxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl)propanoic acid

(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID

(S)-CPW 399

1H-Cyclopentapyrimidine-1-propanoic acid, α-amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-, (αS)-

389888-02-2