(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID
- Product Name
- (S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID
- CAS No.
- 389888-02-2
- Chemical Name
- (S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID
- Synonyms
- (S)-CPW 399;(2S)-2-amino-3-(2,4-dioxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl)propanoic acid;(S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoicacid;(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID;1H-Cyclopentapyrimidine-1-propanoic acid, α-amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-, (αS)-
- CBNumber
- CB4388111
- Molecular Formula
- C10H13N3O4
- Formula Weight
- 239.23
- MOL File
- 389888-02-2.mol
(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Property
- Melting point:
- >163°C (dec.)
- storage temp.
- Desiccate at -20°C
- solubility
- Aqueous Acid (Slightly, Heated, Sonicated), DMSO (Slightly)
- form
- Solid
- color
- Pale Brown to Brown
- Water Solubility
- Soluble to 50 mM in water
N-Bromosuccinimide Price
- Product number
- C781478
- Product name
- (S)-CPW399
- Packaging
- 10mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- C781478
- Product name
- (S)-CPW399
- Packaging
- 50mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- B6781
- Product name
- (S)-CPW399
- Packaging
- 50mg
- Price
- $1362
- Updated
- 2021/12/16
- Product number
- B6781
- Product name
- (S)-CPW399
- Packaging
- 10mg
- Price
- $322
- Updated
- 2021/12/16
- Product number
- API0009819
- Product name
- (S)-CPW 399
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.52
- Updated
- 2021/12/16
(S)-ALPHA-AMINO-2,3,4,5,6,7-HEXAHYDRO-2,4-DIOXO-1H-CYCLOPENTAPYRIMIDINE-1-PROPANOIC ACID Chemical Properties,Usage,Production
Uses
(S)-CPW 399 is a subtype-selective weakly desensitising AMPA agonist.
Biological Activity
Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (K i values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Exhibits potent agonist activity at GluR1 and GluR2 subunit-containing AMPA receptors (EC 50 values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro .
References
[1]. campiani g, morelli e, nacci v, et al. characterization of the 1h-cyclopentapyrimidine-2,4(1h,3h)-dione derivative (s)-cpw399 as a novel, potent, and subtype-selective ampa receptor full agonist with partial desensitization properties. j med chem, 2001, 44(26): 4501-4504.
[2]. sinclair c, reavy h, grieve a, et al. inherent desensitisation-preventing properties of a novel, subtype-selective ampa receptor agonist, (s)-cpw 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. neurochem int, 2003, 42(6): 499-510.
[3]. salonen v, kallinen s, lopez-picon fr, et al. ampa/kainate receptor-mediated up-regulation of gabaa receptor delta subunit mrna expression in cultured rat cerebellar granule cells is dependent on nmda receptor activation. brain res, 2006, 1087(1): 33-40.
[4]. butini s, pickering ds, morelli e, et al. 1h-cyclopentapyrimidine-2,4(1h,3h)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and selective iglur5 modulators. j med chem, 2008, 51(20): 6614-6618.