MELITTIN

Product Name: MELITTIN
CAS No.: 20449-79-0
Chemical Name: MELITTIN
Synonyms: C11198;forapin;forapine;melitten;MELITTIN;MELLITIN;melittini;melittin(major);beevenommelittin;honeybeemelittin
CBNumber: CB4388272
Molecular Formula: C131H229N39O31
Formula Weight: 2846.46
MOL File: 20449-79-0.mol

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MELITTIN Property

alpha: D21 -89.52° (c = 0.409)
Density: 1.39
storage temp.: -20°C
solubility: Soluble to 1 mg/ml in 20% acetonitrile
form: White to faint tan powder.
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
InChIKey: VDXZNPDIRNWWCW-JFTDCZMZSA-N

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 36-45-36/37/39
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: OS3965000
F: 10-21

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M4171
Product name: Melittin
Purity: ≥97% (HPLC), synthetic
Packaging: 250μg
Price: $511
Updated: 2024/03/01

Sigma-Aldrich

Product number: M2272
Product name: Melittin from honey bee venom
Purity: ≥85% (HPLC)
Packaging: 1mg
Price: $83.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: M2272
Product name: Melittin from honey bee venom
Purity: ≥85% (HPLC)
Packaging: 5mg
Price: $280
Updated: 2024/03/01

Cayman Chemical

Product number: 17494
Product name: Melittin
Packaging: 500μg
Price: $107
Updated: 2023/06/20

Cayman Chemical

Product number: 17494
Product name: Melittin
Packaging: 5mg
Price: $796
Updated: 2023/06/20

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MELITTIN Chemical Properties,Usage,Production

Uses

Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.

Uses

Melittin from honey bee venom has been used:

In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Definition

ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.

General Description

Chemical structure: peptide

Biochem/physiol Actions

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.

storage

Store at -20°C

MELITTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MELITTIN Suppliers

China 170 Europe 2 France 1 Germany 1 India 1 Switzerland 1 United Kingdom 7 United States 15 Global 198

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1011
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

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View Lastest Price from MELITTIN manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Melittin 20449-79-0
Price: US $50.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg/week
Release date: 2024-04-24

hebei hongtan Biotechnology Co., Ltd

Product: Melittin 20449-79-0
Price: US $30.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-21

Hebei Mojin Biotechnology Co., Ltd

Product: MELITTIN 20449-79-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-10-22

20449-79-0, MELITTINRelated Search:

PROPOLIS EXTRACT FROM PENNSYLVANIA 4-NITRO-3-(OCTANOYLOXY)BENZOIC ACID MELITTIN Honey CECROPIN A (1-8)-MELITTIN A (3-9) AMIDE,CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE,CECROPIN A-MELITTIN HYBRID PEPTIDE CECROPIN A (1-8)-MELITTIN (1-18) AMIDE MELITTIN,MELITTIN (FREE ACID) MELITTIN SYNTHETIC >99% BEE VENOM POLYPE PTIDE MELITTIN(MELLITIN) MELITTIN,MELITTIN (NATURAL),melittin- (5-aminopentanoyl)melittin (4-aminobutanoyl)melittin Melittin b BIOTINYL-MELITTIN cecropin A(1-8)melittin(1-2) cecropin A(1-7)melittin(2-9) cecropin A(1-8)melittin(1-18) melittin(8-26)

beevenommelittin

forapin

forapine

Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2

Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Glu(NH2)-L-Glu(NH2)-NH2

GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2

C11198

melittin from honey bee venom

BeeVenomCrystalline

BeeVenomLyophilised

Melittin, ≥97% (HPLC)

honeybeemelittin

melitten

melittin(apiscerana)

melittin(honeybee)

melittin(major)

melittini

MELITTIN (NATURAL)

MELITTIN

MELLITIN

GIGAVLKVLTTGLPALISWIKRKRQQ-NH2

GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2

H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2

MELITTIN USP/EP/BP

Melittin (honeybee) (9CI, ACI)

L-Glutamamide, glycyl-L-isoleucylglycy

20449-79-0

C131H229N39O31

Biochemicals and Reagents

Calcium Antagonists

Cell Biology

Cell Signaling and Neuroscience

Chelators

Intracellular Calcium Signaling

Proteomics and Protein Expression

Protein Analysis

Protein Sequencing

Standards for Protein Sequencing

Enzyme Inhibitors

Enzyme Inhibitors by Type

Enzymes, Inhibitors, and Substrates

BioChemical

Amino Acids

Calcium Antagonists

Cell Signaling and Neuroscience

Intracellular Calcium Signaling