ChemicalBook > CAS DataBase List > (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)

(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)

Product Name: (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
CAS No.: 1613465-33-0
Chemical Name: (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
Synonyms: ML-336;ML-336, 10 mM in DMSO;2-[(1,4-Dimethylpiperazin-2-ylidene)amino]-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide;Benzamide, 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-;B355252 2-[(1,4-Dimethylpiperazin-2-ylidene) amino]-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160);ML 336,VEEV V3526 CPE,inhibit,VEEV TC-83 CPE,ML-336,ML336,Virus Protease,VEEV,VEEV Wild Type CPE,venezuelan equine encephalitis virus,Inhibitor
CBNumber: CB43910320
Molecular Formula: C19H21N5O3
Formula Weight: 367.4
MOL File: 1613465-33-0.mol

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(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Property

Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤0.2mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 12.30±0.70(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9001920
Product name: ML-336
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 9001920
Product name: ML-336
Purity: ≥98%
Packaging: 5mg
Price: $227
Updated: 2024/03/01

Cayman Chemical

Product number: 9001920
Product name: ML-336
Purity: ≥98%
Packaging: 10mg
Price: $333
Updated: 2024/03/01

Cayman Chemical

Product number: 9001920
Product name: ML-336
Purity: ≥98%
Packaging: 25mg
Price: $770
Updated: 2024/03/01

ApexBio Technology

Product number: C3581
Product name: ML-336
Packaging: 25mg
Price: $879
Updated: 2021/12/16

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(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Chemical Properties,Usage,Production

Uses

ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1].

Biological Activity

ml-336 is an inhibitor for veev-induced cytopathic effect.alphaviruses like venezuelan equine encephalitis virus (veev) are positive-sense, enveloped, single stranded rna viruses that are widely geographically distributed. veevs are found to be arthropod-borne viruses that are known to cause arthritis, encephalitis, rash, as well as death in humans.

in vitro

ml336 was identified as a first-in-class probe that inhibited a veev-induced cytopathic effect in three strains of the virus, which were v3526, tc-83, and trinidad donkey, in the low nanomolar range without having cytotoxicity (> 50 μm, selectivity index > 1500). in addition, ml336 could reduce viral titer (more than 7.2 log) dramatically below a 1 μm drug concentration. furthermore, ml336 showed a favorable in vitro pk profile that included moderate blood-brain barrier permeability. more importantly, ml336 seemed to be able to target the veev [1].

IC 50

32, 20, and 41 nm for tc-83, v3526, and trinidad donkey strains, respectively.

References

[1] chung d et al. ml336: development of quinazolinone-based inhibitors against venezuelan equine encephalitis virus (veev). probe reports from the nih molecular libraries program. bethesda (md): national center for biotechnology information (us); 2010-2012 dec 17.

(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Preparation Products And Raw materials

Raw materials

Preparation Products

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1613465-33-0, (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)Related Search:

Diethylenetriamine

(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)

(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide

ML-336

Benzamide, 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-

2-[(1,4-Dimethylpiperazin-2-ylidene)amino]-5-nitro-N-phenylbenzamide

B355252 2-[(1,4-Dimethylpiperazin-2-ylidene) amino]-5-nitro-N-phenylbenzamide

ML 336,VEEV V3526 CPE,inhibit,VEEV TC-83 CPE,ML-336,ML336,Virus Protease,VEEV,VEEV Wild Type CPE,venezuelan equine encephalitis virus,Inhibitor

ML-336, 10 mM in DMSO

1613465-33-0