ChemicalBook > CAS DataBase List > AC-LEU-VAL-LYS-ALDEHYDE

AC-LEU-VAL-LYS-ALDEHYDE

Product Name
AC-LEU-VAL-LYS-ALDEHYDE
CAS No.
147600-40-6
Chemical Name
AC-LEU-VAL-LYS-ALDEHYDE
Synonyms
AC-LVK-CHO;AC-LEU-VAL-L-LYSINAL;AC-LEU-VAL-LYS-ALDEHYDE;CATHEPSIN B INHIBITOR II;L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]-
CBNumber
CB4391175
Molecular Formula
C19H36N4O4
Formula Weight
384.51
MOL File
147600-40-6.mol
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AC-LEU-VAL-LYS-ALDEHYDE Property

Boiling point:
665.5±55.0 °C(Predicted)
Density 
1.059±0.06 g/cm3(Predicted)
storage temp. 
-15°C
form 
solid
pka
13.43±0.46(Predicted)
color 
white
Water Solubility 
water: 1mg/mL
Sequence
Ac-Leu-Val-{Lys-Aldehyde}
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219385
Product name
Cathepsin B Inhibitor II
Purity
The Cathepsin B Inhibitor II controls the biological activity of Cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
1MG
Price
$155
Updated
2025/07/31
Biosynth Carbosynth
Product number
FA111043
Product name
Ac-Leu-Val-Lys-aldehyde
Packaging
1mg
Price
$132
Updated
2021/12/16
AK Scientific
Product number
8461CQ
Product name
AC-Leu-val-lys-aldehyde
Packaging
1mg
Price
$228
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA111043
Product name
Ac-Leu-Val-Lys-aldehyde
Packaging
2mg
Price
$230
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA111043
Product name
Ac-Leu-Val-Lys-aldehyde
Packaging
5mg
Price
$459
Updated
2021/12/16
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AC-LEU-VAL-LYS-ALDEHYDE Chemical Properties,Usage,Production

Uses

Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

Biological Activity

Cell permeable: no', 'Primary Target
cathepsin B', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against cathepsin B

IC 50

Cathepsin B: 4 nM (IC50)

References

[1] McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. DOI:10.1021/jm00060a016
[2] Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. DOI:10.1371/journal.pone.0075702

AC-LEU-VAL-LYS-ALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-LEU-VAL-LYS-ALDEHYDE Suppliers

China 37 United Kingdom 2 United States 5 Global 44
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4802
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Nanchang Tianzhen Biotechnology Co., Ltd
Tel
13758194781 13173652190
Email
522013271@qq.com
Country
China
ProdList
2395
Advantage
58
Nanjing TGpeptide Biotechnology Co.,Ltd.
Tel
18115476705
Email
sales@tgpeptide.com
Country
China
ProdList
3058
Advantage
58

147600-40-6, AC-LEU-VAL-LYS-ALDEHYDERelated Search:

GLP-1 (7-37) MAST CELL DEGRANULATING PEPTIDE HR-2 TYR-LEPTIN (26-39) (HUMAN) ARG-ILE-ARG-THR-TRP-LYS-SER-LEU-VAL-LYS GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS-PHE-LEU-TYR-GLN-SER-ASN GLUCAGON-LIKE PEPTIDE-I (7-34) AMIDE, HUMAN H-ARG-ILE-ARG-THR-TRP-LYS-SER-LEU-VAL-LYS-HIS-HIS-MET-TYR-ILE-OH LYS-SER-LEU-VAL-LYS-HIS-HIS-MET-TYR-VAL-SER AC-LEU-VAL-LYS-ALDEHYDE SAPOSIN C (15-32) (RAT) GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS ranalexin SAMS PEPTIDE CALCIUM-LIKE PEPTIDE H-TRP-LYS-SER-LEU-VAL-LYS-HIS-HIS-MET-TYR-ILE-SER-GLY-LYS-ALA-OH H-VAL-ASP-ARG-MET-ARG-ILE-ARG-THR-TRP-LYS-SER-LEU-VAL-LYS-HIS-OH MAST CELL DEGRANULATING PEPTIDE HR-1

  • CATHEPSIN B INHIBITOR II
  • AC-LEU-VAL-L-LYSINAL
  • AC-LEU-VAL-LYS-ALDEHYDE
  • AC-LVK-CHO
  • L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]-
  • 147600-40-6
  • C19H36N4O4