[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Property

storage temp. 

-20°C (des.)

solubility 

Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming).

form 

solid

color 

Beige

Stability:

Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Hazard and Precautionary Statements (GHS)

[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Chemical Properties,Usage,Production

Description

L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD?= 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.1?L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.2

References

1) Dhruv?et al. (2013),?Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis; J. Biol. Chem.,?288?32261 2) Cheng?et al. (2013),?TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic; Front. Immunol.,?4?473