[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
- Product Name
- [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
- CAS No.
- 951612-19-4
- Chemical Name
- [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
- Synonyms
- L524-0366;L524 0366,L5240366,L-524-0366;[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone;(1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)(thiomorpholino)methanone;Methanone, [1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]-4-thiomorpholinyl-
- CBNumber
- CB43916832
- Molecular Formula
- C13H13ClN4OS
- Formula Weight
- 308.79
- MOL File
- 951612-19-4.mol
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Property
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming).
- form
- solid
- color
- Beige
- Stability:
- Stable for 2 years from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Chemical Properties,Usage,Production
Description
L524-0366 (951612-19-4) is an Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD?= 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. L524-0366 completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM.1?L524-0366 is the first compound known to interfere with the TWEAK/Fn14 interaction and may serve as a lead compound for the development of new therapeutics.2
References
1) Dhruv?et al. (2013),?Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis; J. Biol. Chem.,?288?32261 2) Cheng?et al. (2013),?TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic; Front. Immunol.,?4?473
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Preparation Products And Raw materials
Raw materials
Preparation Products
[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Suppliers
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- Country
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