L-Isoserine
- Product Name
- L-Isoserine
- CAS No.
- 632-13-3
- Chemical Name
- L-Isoserine
- Synonyms
- L-ISOSERINE;(S)-LSOSERINE;(S)-ISOSERINE;L-Isoserine>L-Isoserine USP/EP/BP;(S)-2-HYDROXY-B-ALANINE;(s)-2-hydroxy-β-alanine;Terbutaline Impurity 60;(-)-3-Amino-L-lactic acid;(S)-2-HYDROXY-BETA-ALANINE
- CBNumber
- CB4394257
- Molecular Formula
- C3H7NO3
- Formula Weight
- 105.09
- MOL File
- 632-13-3.mol
L-Isoserine Property
- Melting point:
- 199~201℃
- Boiling point:
- 386.6±27.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- pK1:2.72(＋1);pK2:9.25(0) (25°C,μ=0.16)
- color
- White to Almost white
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
- InChIKey
- BMYNFMYTOJXKLE-REOHCLBHSA-N
- SMILES
- C(O)(=O)[C@@H](O)CN
- CAS DataBase Reference
- 632-13-3(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 06054
- Product name
- L-Isoserine
- Purity
- ≥98.0% (TLC)
- Packaging
- 1G-F
- Price
- $155
- Updated
- 2023/06/20
- Product number
- 06054
- Product name
- L-Isoserine
- Purity
- ≥98.0% (TLC)
- Packaging
- 1g
- Price
- $155
- Updated
- 2023/01/07
- Product number
- I0828
- Product name
- L-Isoserine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $22
- Updated
- 2024/03/01
- Product number
- I0828
- Product name
- L-Isoserine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $41
- Updated
- 2024/03/01
- Product number
- H60945
- Product name
- L-Isoserine, 98%
- Packaging
- 250mg
- Price
- $63.65
- Updated
- 2024/03/01
L-Isoserine Chemical Properties,Usage,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Biological Activity
Research has found that L-isoserine showed the ability to inhibit Aminopeptidase N (APN) at a half-maximal inhibitory concentration (IC50 ) value of 563 μM, which could serve as a new lead compound for further chemical modification and optimization. In addition, it has been reported that L-isoserine-L-leucine dipeptide shows moderate aminopeptidase B inhibitory activity (IC50 of 140 μM). This evidence indicates that the incorporation of an amino acid to L-isoserine may contribute to its inhibitory activity against APN. L-isoserine induces long-lasting effects by increasing the expression of GAT3 (glial GABA transporte) in peri-infarct regions[1-2].
References
[1] Yang K , et al. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme inhibition and Medicinal Chemistry, 2011; 27: 302-310.
[2] Lie M , et al. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 2017; 39.
L-Isoserine Preparation Products And Raw materials
Raw materials
Preparation Products
L-Isoserine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
View Lastest Price from L-Isoserine manufacturers
- Product
- L-Isoserine 632-13-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1T+
- Release date
- 2023-09-21
- Product
- L-Isoserine 632-13-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-03