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L-Isoserine

Product Name
L-Isoserine
CAS No.
632-13-3
Chemical Name
L-Isoserine
Synonyms
L-ISOSERINE;(S)-LSOSERINE;(S)-ISOSERINE;L-Isoserine>L-Isoserine USP/EP/BP;(S)-2-HYDROXY-B-ALANINE;(s)-2-hydroxy-β-alanine;Terbutaline Impurity 60;(-)-3-Amino-L-lactic acid;(S)-2-HYDROXY-BETA-ALANINE
CBNumber
CB4394257
Molecular Formula
C3H7NO3
Formula Weight
105.09
MOL File
632-13-3.mol
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L-Isoserine Property

Melting point:
199~201℃
Boiling point:
386.6±27.0 °C(Predicted)
Density 
1.415±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
pK1:2.72(＋1);pK2:9.25(0) (25°C,μ=0.16)
color 
White to Almost white
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey
BMYNFMYTOJXKLE-REOHCLBHSA-N
SMILES
C(O)(=O)[C@@H](O)CN
CAS DataBase Reference
632-13-3(CAS DataBase Reference)
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Safety

WGK Germany 
3
F 
10-21
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
06054
Product name
L-Isoserine
Purity
≥98.0% (TLC)
Packaging
1G-F
Price
$155
Updated
2023/06/20
Sigma-Aldrich
Product number
06054
Product name
L-Isoserine
Purity
≥98.0% (TLC)
Packaging
1g
Price
$155
Updated
2023/01/07
TCI Chemical
Product number
I0828
Product name
L-Isoserine
Purity
>98.0%(T)
Packaging
1g
Price
$22
Updated
2024/03/01
TCI Chemical
Product number
I0828
Product name
L-Isoserine
Purity
>98.0%(T)
Packaging
5g
Price
$41
Updated
2024/03/01
Alfa Aesar
Product number
H60945
Product name
L-Isoserine, 98%
Packaging
250mg
Price
$63.65
Updated
2024/03/01
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L-Isoserine Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Biological Activity

Research has found that L-isoserine showed the ability to inhibit Aminopeptidase N (APN) at a half-maximal inhibitory concentration (IC50 ) value of 563 μM, which could serve as a new lead compound for further chemical modification and optimization. In addition, it has been reported that L-isoserine-L-leucine dipeptide shows moderate aminopeptidase B inhibitory activity (IC50 of 140 μM). This evidence indicates that the incorporation of an amino acid to L-isoserine may contribute to its inhibitory activity against APN.  L-isoserine induces long-lasting effects by increasing the expression of GAT3 (glial GABA transporte) in peri-infarct regions[1-2].

References

[1] Yang K , et al. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme inhibition and Medicinal Chemistry, 2011; 27: 302-310.
[2] Lie M , et al. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 2017; 39.

L-Isoserine Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Isoserine Suppliers

Americas 1 China 169 Europe 3 Germany 4 India 4 Japan 3 Switzerland 1 United Kingdom 5 United States 24 Global 214
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
chemcube
Tel
--
Fax
--
Email
sales@chemcube.eu
Country
Germany
ProdList
4083
Advantage
34
Degussa AG
Tel
--
Fax
--
Email
degussa-bk@degussa.com
Country
Germany
ProdList
641
Advantage
64
Julich Chiral Solutions
Tel
--
Fax
--
Email
info@julich.com
Country
Germany
ProdList
212
Advantage
64
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View Lastest Price from L-Isoserine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Isoserine 632-13-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1T+
Release date
2023-09-21
Career Henan Chemical Co
Product
L-Isoserine 632-13-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-03

632-13-3, L-IsoserineRelated Search:

DL-2-AMINOPROPIONIC ANHYDRIDE DL-ISOSERINE,DL-ISOSERINE 99+% (2r,3s)-n-tert-butoxycarbonyl-3-phenyl-isoserine methyl ester,METHYL (2R,3S)-N-BOC-3-PHENYL ISOSERINE FMOC-DL-ISOSERINE,N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-DL-ISOSERINE (S)-IsoserineL-Isoserine,(R)-ISOSERINE ISOSERINE, N-BETA-T-BUTOXYCARBONYL-DL-ISOSERINE N-(T-BOC)-3-PHENYL ISOSERINE ETHYL ESTER D-Isoserine Isoserine, N,N-dimethyl- (6CI) FMOC-ISOSERINE 2R,3S-N-BENZOYLPHENYL ISOSERINE ( TAXOL SIDE CHAI Isoserine, N-glycyl- (3CI) BOC-ISOSERINE ISOSERINE BOC-ISOSERINE, Isoserine, N-2-pyridyl-, methyl ester, DL- (6CI) N-boca mino phenyl isoserine

  • (S)-ISOSERINE
  • (S)-2-HYDROXY-B-ALANINE
  • (S)-2-HYDROXY-BETA-ALANINE
  • (S)-3-AMINO-2-HYDROXYPROPIONIC ACID
  • L-ISOSERINE
  • (s)-2-hydroxy-β-alanine
  • (S)-LSOSERINE
  • (2S)-3-AMINO-2-HYDROXY-PROPANOIC ACID
  • (-)-3-Amino-L-lactic acid
  • (S)-3-Amino-2-hydroxypropanoic acid
  • (S)-2-Hydroxy-β-alanine, (S)-3-Amino-2-hydroxypropionic acid
  • L-Isoserine&gt
  • Propanoic acid, 3-amino-2-hydroxy-, (2S)-
  • (2S)-3-amino-2-hydroxypropanoicaci
  • L-Isoserine USP/EP/BP
  • Terbutaline Impurity 60
  • 632-13-3
  • 288-16-5
  • 632-11-1632-13-3
  • 632-13-2
  • Specialty Synthesis
  • Serine Derivatives
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • (intermediate of isepamicin)