4-BROMO PHTHALIC ANHYDRUS
Uses- Product Name
- 4-BROMO PHTHALIC ANHYDRUS
- CAS No.
- 86-90-8
- Chemical Name
- 4-BROMO PHTHALIC ANHYDRUS
- Synonyms
- 5-Bromoisobenzofuran-1,3-dione;4-BROMOPHTHALIC ANHYDRIDE;4-BPA;5-Bromophthalic anhydride;5-Bromo-1,3-isobenzofurandione;4-BrPA;TIMTEC-BB SBB008534;4-Bromophthal Anhydride;4-Bromophtalic Anhydride;5-Bromo-2-Benzofuran-1,3
- CBNumber
- CB4395052
- Molecular Formula
- C8H3BrO3
- Formula Weight
- 227.01
- MOL File
- 86-90-8.mol
4-BROMO PHTHALIC ANHYDRUS Property
- Melting point:
- 107 °C
- Boiling point:
- 301 °C
- Density
- 1.911
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- very soluble in Benzene
- form
- powder to crystal
- color
- White to Almost white
- InChI
- InChI=1S/C8H3BrO3/c9-4-1-2-5-6(3-4)8(11)12-7(5)10/h1-3H
- InChIKey
- BCKVHOUUJMYIAN-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(Br)C=C2)C(=O)O1
- CAS DataBase Reference
- 86-90-8(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29173990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B1693
- Product name
- 4-Bromophthalic Anhydride
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $93
- Updated
- 2025/07/31
- Product number
- B1693
- Product name
- 4-Bromophthalic Anhydride
- Purity
- >97.0%(GC)
- Packaging
- 500g
- Price
- $1109
- Updated
- 2025/07/31
- Product number
- B688073
- Product name
- 4-Bromophthalic Anhydride
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B688073
- Product name
- 4-Bromophthalic Anhydride
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B688073
- Product name
- 4-Bromophthalic Anhydride
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
4-BROMO PHTHALIC ANHYDRUS Chemical Properties,Usage,Production
Uses
4-Bromophthalic anhydride is a white or grayish-white crystalline solid at room temperature and pressure. It can be used as an intermediate in organic and biochemical synthesis, and for the derivatization of drug molecules and bioactive molecules. In addition, 4-Bromophthalic anhydride can also be used in the synthesis of dye intermediates and plant growth regulators.
Chemical Properties
off-white to white powder
Synthesis
85-44-9
86-90-8
To a suspension of phthalic anhydride (1) (22 g, 148.5 mmol, 1.0 eq.) in water (150 mL) was slowly added sodium hydroxide (12 g, 300.0 mmol, 2.0 eq.) and pure bromine (8.5 mL, 165.9 mmol, 1.1 eq.). The reaction mixture was stirred at 90 °C for 12 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and filtered to collect a pale yellow solid. After washing the solid with cold water (50 mL), it was dissolved in sulfur dioxide (60 mL) and the mixture was heated to reflux for 5 hours. The reaction mixture was concentrated and dichloromethane (200 mL) was added to the residue and stirred at room temperature for 2 hours. After filtration, the filtrate was concentrated to give 5-bromoisobenzofuran-1,3-dione (2) (20 g, 71% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ 8.16-8.17 (m, 1H), 8.06-8.07 (m, 1H), 7.89-7.90 (m, 1H).
References
[1] Patent: CN105399712, 2016, A. Location in patent: Paragraph 0025
[2] Patent: US2010/204214, 2010, A1. Location in patent: Page/Page column 109
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 1142 - 1150
[4] Patent: WO2018/95260, 2018, A1. Location in patent: Paragraph 058; 060; 0116
[5] Journal of Medicinal Chemistry, 1993, vol. 36, # 22, p. 3417 - 3423
4-BROMO PHTHALIC ANHYDRUS Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO PHTHALIC ANHYDRUS Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-BROMO PHTHALIC ANHYDRUS manufacturers
- Product
- 4-BROMO PHTHALIC ANHYDRUS 86-90-8
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-21
- Product
- 4-Bromophthalic Anhydride 86-90-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2025-03-13
- Product
- 4-Bromophthalic anhydride 86-90-8
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05