O-304

Product Name: O-304
CAS No.: 1261289-04-6
Chemical Name: O-304
Synonyms: O-304;0 304;CS-2682;O-304;0 304;O-304 (O304);O-304 1261289-04-6;O-304, 10 mM in DMSO;O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304;4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide;Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-
CBNumber: CB43960103
Molecular Formula: C16H11Cl2N3O2S
Formula Weight: 380.25
MOL File: 1261289-04-6.mol

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O-304 Property

Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml; Ethanol: slightly soluble
form: A crystalline solid
pka: 7.81±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)
InChIKey: WEDWLYRQKUTOAX-UHFFFAOYSA-N
SMILES: C(NC1SN(CC2=CC=C(Cl)C=C2)C(=O)N=1)(=O)C1=CC=C(Cl)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26186
Product name: O-304
Packaging: 1mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 26186
Product name: O-304
Packaging: 5mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 26186
Product name: O-304
Packaging: 10mg
Price: $448
Updated: 2024/03/01

ChemScene

Product number: CS-0044210
Product name: O-304
Purity: 99.72%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

AK Scientific

Product number: 4737DH
Product name: 4-Chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide
Packaging: 10mg
Price: $596
Updated: 2021/12/16

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O-304 Chemical Properties,Usage,Production

Uses

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

in vivo

O-304 increases glucose uptake in skeletal muscle, reduces β cell stress, and promotes β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin^[2].

References

[1] Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes).

O-304 Preparation Products And Raw materials

Raw materials

Preparation Products

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O-304 Suppliers

China 86 United States 6 Global 92

Shanghai Mumin Biotechnology Co., Ltd

Tel: 17177768578
Email: alisa@pemichem.com
Country: China
ProdList: 299
Advantage: 58

Yichang Chanod Biomedical Technology Co,LTD

Tel: 0717-6855399 15377615856
Email: sales@sndswyy.cn
Country: China
ProdList: 67
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Suzhou Pharmaceutical Technology co.,ltd

Tel: 0510-88771160 18051901298
Fax: 0510-8877116
Email: 2013446823@qq.com
Country: China
ProdList: 52
Advantage: 61

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 2081
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9126
Advantage: 58

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View Lastest Price from O-304 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: O-304 1261289-04-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2025-08-31

Xi an Biohorlden Industry Trade Co Ltd

Product: O-304 1261289-04-6
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: 20kg
Release date: 2025-07-09

1261289-04-6, O-304Related Search:

O-304

O-304 1261289-04-6

4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide

CS-2682

0 304

O-304;0 304

Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-

O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304

O-304, 10 mM in DMSO

O-304 (O304)

1261289-04-6