ChemicalBook > CAS DataBase List > O-304

O-304

Product Name
O-304
CAS No.
1261289-04-6
Chemical Name
O-304
Synonyms
O-304;0 304;CS-2682;O-304;0 304;O-304 (O304);O-304 1261289-04-6;O-304, 10 mM in DMSO;O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304;4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide;Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-
CBNumber
CB43960103
Molecular Formula
C16H11Cl2N3O2S
Formula Weight
380.25
MOL File
1261289-04-6.mol
More
Less

O-304 Property

Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml; Ethanol: slightly soluble
form 
A crystalline solid
pka
7.81±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)
InChIKey
WEDWLYRQKUTOAX-UHFFFAOYSA-N
SMILES
C(NC1SN(CC2=CC=C(Cl)C=C2)C(=O)N=1)(=O)C1=CC=C(Cl)C=C1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26186
Product name
O-304
Packaging
1mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
26186
Product name
O-304
Packaging
5mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
26186
Product name
O-304
Packaging
10mg
Price
$448
Updated
2024/03/01
ChemScene
Product number
CS-0044210
Product name
O-304
Purity
99.72%
Packaging
25mg
Price
$550
Updated
2021/12/16
AK Scientific
Product number
4737DH
Product name
4-Chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide
Packaging
10mg
Price
$596
Updated
2021/12/16
More
Less

O-304 Chemical Properties,Usage,Production

Uses

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

in vivo

O-304 increases glucose uptake in skeletal muscle, reduces β cell stress, and promotes β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin[2].

References

[1] Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes).

O-304 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

O-304 Suppliers

China 86 United States 6 Global 92
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
More
Less

View Lastest Price from O-304 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
O-304 1261289-04-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2025-08-31
Xi an Biohorlden Industry Trade Co Ltd
Product
O-304 1261289-04-6
Price
US $0.00-0.00/g
Min. Order
100g
Purity
99%
Supply Ability
20kg
Release date
2025-07-09

1261289-04-6, O-304Related Search:


  • O-304
  • O-304 1261289-04-6
  • 4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide
  • CS-2682
  • 0 304
  • O-304;0 304
  • Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-
  • O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304
  • O-304, 10 mM in DMSO
  • O-304 (O304)
  • 1261289-04-6