ETHYL 3,3,3-TRIFLUOROPROPIONATE
- Product Name
- ETHYL 3,3,3-TRIFLUOROPROPIONATE
- CAS No.
- 352-23-8
- Chemical Name
- ETHYL 3,3,3-TRIFLUOROPROPIONATE
- Synonyms
- Ethyl 3,3,3-trifluoropropanoate;uoropropionate;RARECHEM AL BI 1046;ETHYL 3,3,3-TRIFLUOROPROPIOTE;ETHYL 3,3,3-TRIFLUOROPROPIONATE;Ethyl3,3,3-trifluoropropionate97%;Ethyl 3,3,3-trifluoropropionate 97%;Ethyl 3,3,3-trifluoropropanoate 97%;Propanoic acid, 3,3,3-trifluoro-, ethyl ester
- CBNumber
- CB4397142
- Molecular Formula
- C5H7F3O2
- Formula Weight
- 156.1
- MOL File
- 352-23-8.mol
ETHYL 3,3,3-TRIFLUOROPROPIONATE Property
- Melting point:
- 109 °C
- Boiling point:
- 50°C 12mm
- Density
- 1.192
- refractive index
- 1.3912
- Flash point:
- 8℃
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Soluble)
- form
- Oil
- color
- Colourless
- InChI
- InChI=1S/C5H7F3O2/c1-2-10-4(9)3-5(6,7)8/h2-3H2,1H3
- InChIKey
- FMDMKDPUFQNVSH-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)CC(F)(F)F
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B440230
- Product name
- ethyl3,3,3-trifluoropropanoate
- Packaging
- 2.5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 008937
- Product name
- Ethyl 3,3,3-trifluoropropionate
- Purity
- 97%
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 2123-3-71
- Product name
- Ethyl 3,3,3-trifluoropropionate
- Purity
- 97%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 034728
- Product name
- Ethyl 3,3,3-Trifluoropropionate
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- JK487457
- Product name
- Ethyl3,3,3-trifluoropropionate
- Purity
- 97%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
ETHYL 3,3,3-TRIFLUOROPROPIONATE Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron Letters, 32, p. 7689, 1991 DOI: 10.1016/0040-4039(91)80566-O
Synthesis
421-90-9
917-58-8
352-23-8
4.4 General procedure for the preparation of ethyl 3,3,3-trifluoropropionate: (1) To a stirred suspension of potassium ethoxide (KOEt, 5.0 g, 59.4 mmol) in ether (Et2O, 200 mL), a solution of 2,2,3-tribromo-1,1,1-trifluoropropane (7, 6.0 g, 17.9 mmol) in ether (Et2O, 50 mL) was slowly added dropwise. The reaction mixture was stirred at room temperature for 15 min. Subsequently, the reaction was quenched with 1 M aqueous hydrochloric acid (50 mL) and stirring was continued for 30 min. The aqueous layer was separated and extracted with ether (50 mL × 3) and the combined organic phases were washed with brine (40 mL) and dried with anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure to give the crude product. Purification of the crude product by distillation afforded ethyl 3,3,3-trifluoropropionate (1, 2.0 g, 72%) as a colorless oil with a boiling point of 106°C (760 mmHg). Product characterization data: IR (pure): 2989, 1747, 1384, 1360, 1267, 1216, 1110, 1026, 929, 836, 755, 653 cm-1. 1H NMR (400 MHz, CDCl3): δ 4.24 (q, J = 7.2 Hz, 2H), 3.17 (q, J = 10.1 Hz, 2H), 1.30 (t, J = 7.2 Hz, 3H). 13C NMR (100 MHz, CDCl3): δ 164.1 (q, JCF = 4.1 Hz, 1C), 123.4 (q, JCF = 274.5 Hz, 1C), 61.7 (1C), 39.5 (q, JCF = 30.8 Hz, 1C), 13.8 (1C). 19F NMR (376 MHz, CDCl3): δ -64.8 (t, JHF = 10.1 Hz, 3F). EI-MS m/z (relative abundance): 156 [M]+ (2.4), 141 [M-Me]+ (1.4), 129 [M+2H-Et]+ (8.2), 111 [M-OEt]+ (100), 91 [CF2CHCO]+ (12.9), 83 [CF3CH2]+ (15.7), 69 [CF3]+ (7.5) , 45 [EtO]+ (41.4).
References
[1] Journal of Fluorine Chemistry, 2014, vol. 167, p. 135 - 138
ETHYL 3,3,3-TRIFLUOROPROPIONATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 3,3,3-TRIFLUOROPROPIONATE Suppliers
- Tel
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- Fax
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- sales@rarechem.de
- Country
- Germany
- ProdList
- 6297
- Advantage
- 38
- Tel
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- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
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View Lastest Price from ETHYL 3,3,3-TRIFLUOROPROPIONATE manufacturers
- Product
- Ethyl 3,3,3-trifluoropropanoate 352-23-8
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- ETHYL 3,3,3-TRIFLUOROPROPIONATE 352-23-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- ETHYL 3,3,3-TRIFLUOROPROPIONATE 352-23-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08