ChemicalBook > CAS DataBase List > 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE

1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE

Product Name: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE
CAS No.: 2605-68-7
Chemical Name: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE
Synonyms: LCZ-696 Impurity 78;Sacubitril Impurity 80;Methyl 2-(triphenylphosphoranediyl)propionate;Methyl 2-(triphenylphosphoranylidene)propanoate;1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE;2-(Triphenylphosphoranylidene)propionic acid methyl ester;2-(Triphenylphosphoranylidene)-propanoic acid methyl ester;Propanoic acid,2-(triphenylphosphoranylidene)-, methyl ester
CBNumber: CB4397162
Molecular Formula: C22H21O2P
Formula Weight: 348.37
MOL File: 2605-68-7.mol

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1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE Property

Melting point:: 153-156℃ (ethyl acetate )
Boiling point:: 485.8±28.0 °C(Predicted)
Density: 1.16±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: T4194
Product name: Methyl 2-(Triphenylphosphoranylidene)propanoate
Packaging: 200MG
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: T4194
Product name: Methyl 2-(Triphenylphosphoranylidene)propanoate
Packaging: 1G
Price: $195
Updated: 2025/07/31

AK Scientific

Product number: 2221AB
Product name: Methyl2-(triphenylphosphoranylidene)propanoate
Packaging: 100mg
Price: $107
Updated: 2021/12/16

BroadPharm

Product number: BP-20608
Product name: CARBMETHOXYETHYLIDENETRIPHENYLPHOSPHORANE
Purity: 97%
Packaging: 1g
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0001608
Product name: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE
Purity: 95.00%
Packaging: 250MG
Price: $430.25
Updated: 2021/12/16

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1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE Chemical Properties,Usage,Production

Synthesis

5445-17-0

603-35-0

2605-68-7

General procedure for the synthesis of methyl 2-(triphenylphosphoranylidene)propionate from methyl 2-bromopropionate and triphenylphosphine: first, 5 g (19.06 mmol) of triphenylphosphine was dissolved in 15 ml of toluene. Subsequently, an aqueous solution prepared by dissolving 0.32 g (1.90 mmol) of potassium iodide in 15 ml of distilled water mixed with 3.2 ml (28.6 mmol) of methyl 2-bromopropionate was added to this solution. The reaction mixture was stirred continuously at 70°C for 20 hours. After completion of the reaction, the mixture was cooled to room temperature and alkalized by adjusting the pH to 9 with 10N aqueous sodium hydroxide solution, followed by extraction with dichloromethane. The organic layer was collected and dried with anhydrous sodium sulfate, followed by filtration under reduced pressure and distillation under reduced pressure. The resulting solid was washed with hexane and again subjected to filtration under reduced pressure and drying under reduced pressure to give 6.0 g (yield: 91%) of the target product methyl 2-(triphenylphosphoranylidene)propionate.

References

[1] Patent: KR2015/77974, 2015, A. Location in patent: Paragraph 0033-0034; 0053-0055
[2] Organic and Biomolecular Chemistry, 2017, vol. 15, # 34, p. 7102 - 7105
[3] Helvetica Chimica Acta, 1979, vol. 62, p. 1025 - 1039
[4] Tetrahedron Letters, 1984, vol. 25, # 51, p. 5881 - 5884
[5] Angewandte Chemie - International Edition, 2012, vol. 51, # 38, p. 9587 - 9591

1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE Preparation Products And Raw materials

Raw materials

Preparation Products

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2605-68-7, 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANERelated Search:

Ethyl (triphenylphosphoranylidene)acetate AURORA KA-1059 2-(TRIPHENYLPHOSPHORANYLIDENE)SUCCINIC ANHYDRIDE AURORA KA-1073 ETHYL 4,4,4-TRIFLUORO-2-(TRIPHENYLPHOSPHORANYLIDENE)ACETOACETATE SALOR-INT L150010-1EA AURORA KA-1179 METHYL 2-[5-(4-CHLOROPHENYL)-2-HYDROXY-3-OXO-2,3-DIHYDROFURAN-2-YL]-2-(1,1,1-TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)ACETATE Ethyl 2-(triphenylphosphoranylidene)propionate 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE SPECS AE-848/33625045 METHYL 3-OXO-3-[3-(TRIFLUOROMETHYL)PHENYL]-2-(TRIPHENYLPHOSPHORANYLIDENE)PROPANOATE METHYL 2-(2-HYDROXY-3-OXO-5-PHENYL-2,3-DIHYDROFURAN-2-YL)-2-(1,1,1-TRIPHENYL-LAMBDA5-PHOSPHANYLIDENE)ACETATE

2-(Triphenylphosphoranylidene)-propanoic acid methyl ester

2-(Triphenylphosphoranylidene)propionic acid methyl ester

Methyl 2-(triphenylphosphoranediyl)propionate

1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE

Methyl 2-(triphenylphosphoranylidene)propanoate

Propanoic acid,2-(triphenylphosphoranylidene)-, methyl ester

LCZ-696 Impurity 78

Sacubitril Impurity 80

2605-68-7