ChemicalBook > CAS DataBase List > Ethyl 2-(triphenylphosphoranylidene)propionate
Ethyl 2-(triphenylphosphoranylidene)propionate
- Product Name
- Ethyl 2-(triphenylphosphoranylidene)propionate
- CAS No.
- 5717-37-3
- Chemical Name
- Ethyl 2-(triphenylphosphoranylidene)propionate
- Synonyms
- (CARBETHOXYETHYLIDENE)TRIPHENYLPHOSPHORANE;CEETPP;CEY;AURORA KA-4803;idene)triphenyL;(CarbethoxyethyL;LABOTEST-BB LT00454031;Sacubitril Impurity 81;Sacubitril/Valsartan intermediates;1-Ethoxycarbonyl-ethyliden-phosphoran
- CBNumber
- CB6381055
- Molecular Formula
- C23H23O2P
- Formula Weight
- 362.4
- MOL File
- 5717-37-3.mol
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Ethyl 2-(triphenylphosphoranylidene)propionate Property
- Melting point:
- 158-162 °C (lit.)
- Boiling point:
- 497.2±28.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- color
- Yellow
- Water Solubility
- Soluble in water.
- Sensitive
- Air Sensitive
- BRN
- 757112
- InChIKey
- KZENFXVDPUMQOE-UHFFFAOYSA-N
- CAS DataBase Reference
- 5717-37-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanoic acid, 2-(triphenylphosphoranylidene)-, ethyl ester(5717-37-3)
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Safety
- Hazard Codes
- T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 45-37/39-26
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29319090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 377708
- Product name
- (Carbethoxyethylidene)triphenylphosphorane
- Purity
- 94%
- Packaging
- 5g
- Price
- $62.2
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 377708
- Product name
- (Carbethoxyethylidene)triphenylphosphorane
- Purity
- 94%
- Packaging
- 25g
- Price
- $217
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C1641
- Product name
- Ethyl 2-(Triphenylphosphoranylidene)propionate
- Purity
- >97.0%(HPLC)
- Packaging
- 5g
- Price
- $84
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15619
- Product name
- (1-Ethoxycarbonylethylidene)triphenylphosphorane, 97%
- Packaging
- 10g
- Price
- $77.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15619
- Product name
- (1-Ethoxycarbonylethylidene)triphenylphosphorane, 97%
- Packaging
- 25g
- Price
- $168.65
- Updated
- 2024/03/01
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Ethyl 2-(triphenylphosphoranylidene)propionate Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
(1-Ethoxycarbonylethylidene)triphenylphosphorane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals. It?s also a Horner-Wadsworth-Emmons reagent. It can be used for olefination. It can also be utilized for the synthesis of more complex compounds, such as (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor.
Synthesis
Ethyl 2-(triphenylphosphoranylidene)propionate was prepared this reagent from ethyl 2-bromopropanoate and triphenylphosphine.A 500-mL, one-necked, round-bottomed flask equipped with an egg-shaped magnetic stirring bar is charged with triphenylphosphine (52.46 g, 200.0 mmol), ethyl acetate (130 mL), and ethyl 2-bromopropanoate (26.03 mL, 200.0 mmol). A reflux condenser is attached to the flask and the solution is heated under reflux (oil bath temperature: 75-80 °C) under argon for 24 h. The resulting white precipitate is collected through suction filtration on a Büchner funnel and washed with ethyl acetate (100 mL). The salt is dissolved in dichloromethane (500 mL) and the solution is transferred to a 1-L separation funnel. Aqueous sodium hydroxide solution (2 M, 200 mL) is added and, after vigorously shaking, the organic and aqueous layers are separated. The aqueous phase is extracted with dichloromethane (100 mL). The combined organic phases are washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated at 30 °C under rotary evaporation (20-25 mmHg); drying under vacuum (0.1-0.2 mmHg) affords 54.51 g (75.2%) of ethyl 2-(triphenylphosphoranylidene)propionate as a light-yellow solid, mp 156-158 °C.
Ethyl 2-(triphenylphosphoranylidene)propionate Preparation Products And Raw materials
Raw materials
Preparation Products
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Ethyl 2-(triphenylphosphoranylidene)propionate Suppliers
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View Lastest Price from Ethyl 2-(triphenylphosphoranylidene)propionate manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- (Carbethoxyethylidene)triphenylphosphorane 5717-37-3
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-13
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Ethyl 2-(triphenylphosphoranylidene)propionate 5717-37-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-23
Henan Aochuang Chemical Co.,Ltd.
- Product
- Ethyl 2-(triphenylphosphoranylidene)propionate 5717-37-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-30
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