ChemicalBook > CAS DataBase List > METHYL PIPECOLINATE HYDROCHLORIDE

METHYL PIPECOLINATE HYDROCHLORIDE

Product Name: METHYL PIPECOLINATE HYDROCHLORIDE
CAS No.: 32559-18-5
Chemical Name: METHYL PIPECOLINATE HYDROCHLORIDE
Synonyms: METHYL PIPERIDINE-2-CARBOXYLATE HYDROCHLORIDE;H-DL-Pip-OMe·HCl;TIMTEC-BB SBB003755;METHY PIPECOLINATE HCL;METHYL PIPECOLINATE HCL;MethyPipecolinateHydrochloride;METHYL PIPECOLINATE HYDROCHLORIDE;N-methyl pipecolinate hydrochloride;Methyl piperidine-2-carboxylate HCl;pipecolinic acid methyl ester hydrochloride
CBNumber: CB4398811
Molecular Formula: C7H14ClNO2
Formula Weight: 179.64
MOL File: 32559-18-5.mol

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METHYL PIPECOLINATE HYDROCHLORIDE Property

Melting point:: 205 °C (dec.)(lit.)
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 391204
Product name: Methyl pipecolinate hydrochloride
Purity: 97%
Packaging: 5g
Price: $191
Updated: 2023/01/07

Sigma-Aldrich

Product number: 391204
Product name: Methyl pipecolinate hydrochloride
Purity: 97%
Packaging: 25g
Price: $270
Updated: 2023/01/07

TRC

Product number: M329738
Product name: Methyl pipecolinate hydrochloride
Packaging: 5g
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J94316
Product name: MethypipecolinateHCl
Packaging: 100g
Price: $68
Updated: 2021/12/16

AK Scientific

Product number: B019
Product name: MethypipecolinateHCl
Packaging: 100g
Price: $88
Updated: 2021/12/16

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METHYL PIPECOLINATE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Methyl Pipecolinate Hydrochloride is a reactant for synthesis of a pipecolic linker and antiviral agents.

General Description

Methyl pipecolinate hydrochloride is a hydrochloride salt of methyl piperidine-2-carboxylate (methyl pipecolinate). The kinetics of the enzymatic separation of enantiomeric forms of methyl pipecolinate using Candida antarctica Lipase A (CAL-A) has been reported. Its role as catalyst for the standard Diels-Alder reaction has been examined.

Synthesis

67-56-1

4043-87-2

32559-18-5

Synthesis of methylpiperidine-2-carboxylic acid hydrochloride: methanol (1300 mL) was added to a 3000 mL three-necked round bottom flask. The reaction system was cooled to -30°C. Sulfoxide chloride (280 mL) was added slowly and dropwise under stirring conditions while keeping the temperature at -30 °C. Subsequently, piperidine-2-carboxylic acid (100 g, added in batches) was added to the reaction system and the mixture was cooled to 0 °C. The reaction was continuously stirred for 15 h at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was methanol and a few drops of ammonia were added). After completion of the reaction, the reaction mixture was concentrated under vacuum using a rotary evaporator. Toluene (100 mL) was added to the concentrate and kept under reflux conditions. The mixture was again concentrated under vacuum using a rotary evaporator. This toluene addition and concentration step was repeated twice. The final product was 137 g (98% yield) of methylpiperidine-2-carboxylic acid hydrochloride as a white solid.

References

[1] European Journal of Organic Chemistry, 2014, vol. 2014, # 29, p. 6467 - 6480
[2] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 38; 39
[3] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 5, p. 1199 - 1212
[4] Tetrahedron Letters, 2006, vol. 47, # 29, p. 5017 - 5020
[5] Chemistry - A European Journal, 2010, vol. 16, # 25, p. 7547 - 7553

METHYL PIPECOLINATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL PIPECOLINATE HYDROCHLORIDE manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: Methyl piperidine-2-carboxylate HCl 32559-18-5
Price: US $15.00-50.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 5 ton per month
Release date: 2023-04-02

Hebei Runbin Biotechnology Co. LTD

Product: METHYL PIPECOLINATE HYDROCHLORIDE 32559-18-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 10tons
Release date: 2020-08-24

Career Henan Chemical Co

Product: METHYL PIPECOLINATE HYDROCHLORIDE 32559-18-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 448
Release date: 2019-09-01

32559-18-5, METHYL PIPECOLINATE HYDROCHLORIDERelated Search:

Ethyl piperidine-2-carboxylate hydrochloride 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Piperidine-3,5-dione hydrochloride Pipecolamide 2,6-piperidinedicarboxylic acid 2-FORMYLPIPERIDINE HYDROCHLORIDE PIPERIDINE-1-SULFONYL CHLORIDE 4-Piperidinyl(1-pyrrolidinyl)Methanone hydrochloride 1-Aminopiperidine 3-Hydroxypiperidine hydrochloride piperidin-4-ylMethanesulfonaMide Piperidinium acetate Ethyl piperidine-3-carboxylate hydrochloride N-Methyl-3-carbomethoxy-4-piperidone hydrochloride (R)-Piperidine-2-carboxylic acid methyl ester hydrochloride Pimecrolimus Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride H-HOMOPRO-OME HCL

METHYL PIPERIDINE-2-CARBOXYLATE HYDROCHLORIDE

METHYL PIPECOLINATE HCL

METHYL PIPECOLINATE HYDROCHLORIDE

TIMTEC-BB SBB003755

METHY PIPECOLINATE HCL

MethyPipecolinateHydrochloride

N-methyl pipecolinate hydrochloride

Methyl 2-piperidinecarboxylate hydrochloride

2-piperidinecarboxylic acid methyl ester hydrochloride

pipecolinic acid methyl ester hydrochloride

2-Piperidinecarboxylicacid, methyl ester, hydrochloride (1:1)

H-DL-Pip-OMe·HCl

Methyl piperidine-2-carboxylate HCl

32559-18-5

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