Losartan carboxylic acid

Product Name: Losartan carboxylic acid
CAS No.: 124750-92-1
Chemical Name: Losartan carboxylic acid
Synonyms: exp3174;Losartan Carboxylic Acid;e-3174;LOSARTAN CARBOXY ACID;EXP 317;l-158641;AKOS 91941;ALSTint-A07;Losartan acid;E-3174, EXP-3174
CBNumber: CB4399601
Molecular Formula: C22H21ClN6O2
Formula Weight: 436.89
MOL File: 124750-92-1.mol

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Losartan carboxylic acid Property

Melting point:: 130-132°C
Boiling point:: 707.8±70.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Dimethylformamide, Dimethyl Sulfoxide, Methanol
form: Solid
pka: 0.79±0.50(Predicted)
color: Light-Yellow
InChI: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
InChIKey: ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES: C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H362May cause harm to breast-fed children

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB01354
Product name: Losartan carboxylic acid
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $75.9
Updated: 2023/01/07

Sigma-Aldrich

Product number: SMB01354
Product name: Losartan carboxylic acid
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $303
Updated: 2023/01/07

Cayman Chemical

Product number: 15957
Product name: Losartan Carboxylic Acid
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 15957
Product name: Losartan Carboxylic Acid
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 15957
Product name: Losartan Carboxylic Acid
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

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Losartan carboxylic acid Chemical Properties,Usage,Production

Description

Losartan carboxylic acid is a physiologically active metabolite of losartan , produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT₁ antagonist (K_is = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation in vitro.

Chemical Properties

Light-Yellow Solid

Uses

Losartan carboxylic acid is used as a metabolite of Losartan.

Definition

ChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.

in vitro

e-3174 potently blocked the specific binding of [125i]-aii to vsmc isolated from rat aorta. e-3174 was able to dampen the platelet-derived growth factor-induced increase in cell dna synthesis and protein, which led to the blockade of the aii-induced increase in cell protein [1].

in vivo

rats were administrated e-3174 intravenously at a dose of l.0 mg/kg. after 6 hours, e-3174 markedly attenuated the cardiovascular effects of aii in rats. e-3174 induced a progressive fall in mean arterial pressure and a marked increase in renal flow only [2].

storage

Store at -20°C

References

[1]. li, x. & widdop, r. angiotensin type i receptor antagonists cy-11974 and exp 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats. clinical science, 1996; 91(2): 147-154.
[2]. sachinidis, a., ko, y., weisser, p., zu bricbkwedde, m., dsing, r., & christian, r. et al. exp3174, a metabolite of losartan (mk954, dup753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells. journal of hypertension. 1993; 11(2): 155-162.

Losartan carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Losartan

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Losartan carboxylic acid Suppliers

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View Lastest Price from Losartan carboxylic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Losartan Carboxylic Acid 124750-92-1
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

Career Henan Chemical Co

Product: 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID 124750-92-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 200kgs
Release date: 2020-01-17

124750-92-1, Losartan carboxylic acidRelated Search:

Losartan potassium Ethyl acetate Metoprolol Candesartan cilexetil Valsartan Irbesartan Losartan Trityl losartan 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]-methyl-1H-imidazole-5-carboxylic acid (LOSARTAN METABOLITE). AKOS 91707 AKOS 91711 Losartan carboxylic acid

LOSARTAN CARBOXY ACID

AKOS 91941

2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID

’-biphenyl)-4-yl)methyl)-

1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2’-(14-tetrazol-5-yl)(1,1

E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174

2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid

E-3174, EXP-3174

2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid

1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

ALSTint-A07

2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formic acid

LOSARTAN,2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID

Losartan Impurity 14

2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicAcid

EXP 317

Losartan Carboxylic AcidDiscontinued see product # L470510

Losartan Carboxylic Acid

e-3174

exp3174

l-158641

EXP 3174 (LOSARTAN CARBOXYLIC ACID)

2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-carboxylic acid

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic acid

2-Butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid

1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

Losartan Carboxylic Acid NEW CATALOGUE NUMBER: see product # L470510

Losartan acid

Losartan carboxylic acid, >=98%

1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1

E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1;1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID

Losartan Carboxylic Acid USP/EP/BP

2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID USP/EP/BP

Losartan Carboxylic Acid (Losartan Carboxylate)

Losartan Carboxylic acid Impurity

Losartan carboxylic acidQ: What is Losartan carboxylic acid Q: What is the CAS Number of Losartan carboxylic acid Q: What is the storage condition of Losartan carboxylic acid Q: What are the applications of Losartan carboxylic acid

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Losartan Carboxylic Acid)

Losartan carboxylic acid in methanol

124750-92-1

C22H21ClN6O2

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Heterocycles