ChemicalBook > CAS DataBase List > 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
96551-22-3
Chemical Name
3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
Ethanol,7-diazenyl-;Benzene,1-ethenyl-6-nitro-;1-BOC-3-HYDROXYMETHYL-INDOLE;N-BOC-3-(HYDROXYMETHYL)INDOLE;3-(Hydroxymethyl)indole, N-BOC;3-(HYDROXYMETHYL)INDOLE, N-BOC PROTECTED;3-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE;t-butyl 3-hydroxymethylindole-1-carboxylate;3-(Hydroxymethyl)-1H-indole, N-BOC protected;3-(Hydroxymethyl)indole, N-BOC protected 98%
CBNumber
CB4401612
Molecular Formula
C14H17NO3
Formula Weight
247.29
MOL File
96551-22-3.mol
More
Less

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:
396.0±34.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Dichloromethane
form 
Solid
pka
14.38±0.10(Predicted)
color 
Light Brown
More
Less

Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
H946760
Product name
3-Hydroxymethyl-1H-indole-1-carboxylicAcidtert-ButylEster
Packaging
10g
Price
$285
Updated
2021/12/16
AK Scientific
Product number
W9813
Product name
1-Boc-3-Hydroxymethylindole
Packaging
10g
Price
$339
Updated
2021/12/16
AK Scientific
Product number
W9813
Product name
1-Boc-3-Hydroxymethylindole
Packaging
5g
Price
$207
Updated
2021/12/16
Matrix Scientific
Product number
043167
Product name
tert-Butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate
Purity
>95%
Packaging
1g
Price
$157
Updated
2021/12/16
SynQuest Laboratories
Product number
4H51-1-47
Product name
3-(Hydroxymethyl)-1H-indole, N-Boc protected
Packaging
1g
Price
$168
Updated
2021/12/16
More
Less

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is Light Brown Solid

Uses

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER can be used in the preparation of arylpiperidinones for treatment of inflammation.

Synthesis

57476-50-3

96551-22-3

Step 2. To a solution of tert-butyl 3-formyl-1H-indole-1-carboxylate (44 g, 0.17 mol) in anhydrous ethanol (50 mL) was added sodium borohydride (16.6 g, 0.45 mol) in batches at 0 °C. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was filtered to remove insoluble material. The filtrate was rotary evaporated to remove ethanol. The residue was dissolved in ethyl acetate (100 mL) and water (50 mL) for partitioning. The aqueous layer was further extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate (40 g, 95% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.59 (s, 9H), 4.77 (s, 2H), 7.19 (t, 1H), 7.25 (t, 1H), 7.51 (s, 1H), 7.57 (d, 1H), 8.06 (d, 1H).

References

[1] Liebigs Annalen der Chemie, 1985, # 2, p. 413 - 417
[2] Journal of Organic Chemistry, 2016, vol. 81, # 4, p. 1723 - 1730
[3] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 8, p. 1242 - 1247
[4] Patent: WO2013/148365, 2013, A1. Location in patent: Paragraph 0083
[5] Synthetic Communications, 2000, vol. 30, # 12, p. 2143 - 2159

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Canada 2 China 77 Germany 1 India 1 United Kingdom 3 United States 14 Global 98
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Shanghai Paulshine Chemical Co., Ltd.
Tel
+86-021-37788663
Fax
+86-021-37788663
Country
China
ProdList
186
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Shanghai Sheepchem Co., Ltd.
Tel
+86 (21) 6715-7650
Fax
+86 (21) 6715-7651
Email
sheepchem@163.com
Country
China
ProdList
994
Advantage
60
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Hangzhou Trylead Chemical Technology Co.,LTD
Tel
0571-87086220 13516718938
Fax
0571-87012927
Email
zyf@trylead-chem.com
Country
China
ProdList
310
Advantage
64
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 0086-15250997978
Fax
025-58362220
Email
sale@njxizebio.com
Country
China
ProdList
4855
Advantage
55
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Shanghai Chenzhu Pharmaceutical Co., Ltd.
Tel
13162380607
Fax
QQ:1696175688
Email
1696175688@qq.com
Country
China
ProdList
817
Advantage
55
Shanghai times pharmaceutical technology co., LTD.
Tel
021-31663164
Fax
021-31663164
Email
2598357323@qq.com
Country
China
ProdList
362
Advantage
55
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1980
Advantage
55
Shanghai Shanyuan pharmaceutical technology co., LTD
Tel
021-31761238 13167072949
Fax
021-31761238
Email
3146446224@qq.com
Country
China
ProdList
1379
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Civic Chemical Technology Co., Ltd.
Tel
021-34053660
Fax
QQ:2881074831
Email
sale2@labgogo.com
Country
China
ProdList
2018
Advantage
58
Dalian lichuang Chemical Co., Ltd
Tel
0411-0411-00000000 13644282108
Fax
-
Email
3500508746@qq.com
Country
China
ProdList
2896
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
Advantage
58
CASNO Chem Ltd.
Tel
86-13710190520
Fax
-
Email
sales@casnochem.com
Country
China
ProdList
313
Advantage
58
Shanghai Baozhi Biological Technology Co., Ltd.
Tel
13764058804
Email
3438424070@qq.com
Country
China
ProdList
376
Advantage
58
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Shanghai HongMin Pharmaceutical Co., Ltd.
Tel
13651987816
Fax
-
Email
hongminpharm@163.com
Country
China
ProdList
2326
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
9972
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai Medicil Biomedical Co., Ltd.
Tel
021-50822001
Email
marketing@medicilon.com.cn
Country
China
ProdList
1152
Advantage
58
wuhan Dekray Biomedical Technology Co.,Ltd
Tel
027-69573188 18221423799
Email
1503407886@qq.com
Country
China
ProdList
1439
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
CD Chemical Group Limited
Tel
+8615986615575
Fax
0086-13651442114
Email
info@codchem.com
Country
China
ProdList
20342
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Suzhou Dongji Chemical Technology Co., Ltd.
Tel
18516099287
Email
3045383737@qq.com
Country
China
ProdList
230
Advantage
58
Amel Pharmatech Corporation
Tel
027-888-4366503
Fax
888-502-1736
Email
sales@amelpharmatech.com
Country
China
ProdList
5000
Advantage
58
Block Chemical Technology (Shanghai) Co., LTD
Tel
021-20432219 13918097649
Fax
QQ79021576
Email
li_jinfei@acblock-lab.com
Country
China
ProdList
9673
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
10467
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Shanghai Safer Pharmaceutical Technology Co., Ltd.
Tel
021-31761238
Fax
021-31761238
Email
sales@saferph.com
Country
CHINA
ProdList
897
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Andxi Pharm Co., Ltd.
Tel
19951207836
Fax
QQ: 3097966864
Email
3119034156@qq.com
Country
China
ProdList
494
Advantage
58
More
Less

View Lastest Price from 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co
Product
1-Boc-3-Hydroxymethylindole 96551-22-3
Price
US $2.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100kg
Release date
2019-12-20

96551-22-3, 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-5-NITROINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-1H-T-BUTOXYCARBONYL-INDOLE-3-CARBOXYLIC ACID 3-HYDROXYMETHYL-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1H-INDOLE-1,3-DICARBOXYLIC ACID, 4-BROMO-, 1-(1,1-DIMETHYLETHYL)ESTER INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER 5-CYANO-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-HYDROXY-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 7-BENZYLOXY-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-5-METHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-CHLORO-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-7-NITROINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-2-METHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-6-METHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-7-METHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-BROMO-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-6-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 3-(HYDROXYMETHYL)INDOLE, N-BOC PROTECTED
  • 3-(Hydroxymethyl)indole, N-BOC protected 98%
  • N-BOC-3-(HYDROXYMETHYL)INDOLE
  • 3-(Hydroxymethyl)-1H-indole, N-BOC protected
  • 3-(Hydroxymethyl)-1H-indole-1-carboxylic acid tert-butyl ester
  • TERT-BUTYL 3-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE
  • 1-BOC-3-HYDROXYMETHYL-INDOLE
  • 3-(HYDROXYMETHYL)-1H-INDOLE-1-CARBOXYLATE
  • 3-(Hydroxymethyl)indole, N-BOC
  • t-butyl 3-hydroxymethylindole-1-carboxylate
  • 3-HydroxyMethyl-1H-indole-1-carboxylic Acid 1,1-DiMethylethyl Ester
  • tert-Butyl 3-(hydroxyMethyl)indole-1-carboxylate
  • Benzene,1-ethenyl-6-nitro-
  • Ethanol,7-diazenyl-
  • 96551-22-3
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API intermediates