INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
- Product Name
- INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
- CAS No.
- 338760-26-2
- Chemical Name
- INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
- Synonyms
- METHYL 1-BOC-1H-INDOLE-3-CARBOXYLATE;tert-butyl methyl 1H-indole-1,3-dicarboxylate;1-tert-Butyl 3-Methyl 1H-indole-1,3-dicarboxylate;methyl 1-tert-butoxycarbonyl-1H-indole-3-carboxylate;INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER;1H-Indole-1,3-dicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
- CBNumber
- CB0103868
- Molecular Formula
- C15H17NO4
- Formula Weight
- 275.3
- MOL File
- 338760-26-2.mol
INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Property
- Melting point:
- 127.0 °C
- Boiling point:
- 387.3±34.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB139922
- Product name
- 1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
- Packaging
- 250mg
- Price
- $87.5
- Updated
- 2021/12/16
- Product number
- FB139922
- Product name
- 1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- Z4617
- Product name
- 1-tert-Butyl3-methyl1H-indole-1,3-dicarboxylate
- Packaging
- 250mg
- Price
- $168
- Updated
- 2021/12/16
- Product number
- FB139922
- Product name
- 1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- FB139922
- Product name
- 1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
- Packaging
- 2g
- Price
- $460
- Updated
- 2021/12/16
INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Chemical Properties,Usage,Production
Synthesis
942-24-5
24424-99-5
338760-26-2
Methyl indole-3-carboxylate (17.1 mmol) was placed in a 50 mL round-bottomed flask, NaH (1.5 eq.) was added and cooled under ice bath conditions. THF (20 mL) was added slowly and stirred for 30 minutes. Subsequently, di-tert-butyl dicarbonate (1.5 eq.) was added and the reaction continued to stir overnight. Upon completion of the reaction, the reaction was quenched with saturated NaHCO3 solution, the reaction mixture was diluted with ether and washed with water. The organic layer was dried with anhydrous Na2SO4 and concentrated. The crude product was purified by column chromatography (ethyl acetate/hexane as eluent) to give 3-methyl-1H-indole-1,3-dicarboxylic acid-1-tert-butyl ester in 98% yield.
References
[1] Patent: US2009/215828, 2009, A1. Location in patent: Page/Page column 13
[2] Patent: WO2009/103552, 2009, A1. Location in patent: Page/Page column 31
[3] Research on Chemical Intermediates, 2017, vol. 43, # 3, p. 1355 - 1363
[4] Tetrahedron, 2003, vol. 59, # 6, p. 747 - 754
[5] Chemistry - A European Journal, 2010, vol. 16, # 48, p. 14534 - 14544
INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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