TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE
Uses- Product Name
- TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE
- CAS No.
- 57476-50-3
- Chemical Name
- TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE
- Synonyms
- 1-Boc-3-formylindole;1-Boc-Indole-3-carboxaldehyde;3-FORMYLINDOLE, N-BOC PROTECTED;tertbutyl 3-formyl-1H-indole-1-formate;TERT-BUTYL 3-FORMYLINDOLE-1-CARBOXYLATE;INDOLE-3-CARBOXALDEHYDE, N-BOC PROTECTED;1H-Indole-3-carboxaldehyde, N-BOC protected;TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE;tert-butyl 2-(3-formyl-1H-indol-1-yl)acetate;3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber
- CB9132010
- Molecular Formula
- C14H15NO3
- Formula Weight
- 245.27
- MOL File
- 57476-50-3.mol
TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE Property
- Melting point:
- 119-121°C
- Boiling point:
- 380.0±34.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- KOB0061
- Product name
- tert-Butyl 3-formyl-1H-indole-1-carboxylate
- Packaging
- 1G
- Price
- $179
- Updated
- 2025/07/31
- Product number
- D6036
- Product name
- tert-Butyl 3-Formyl-1H-indole-1-carboxylate
- Packaging
- 5G
- Price
- $71
- Updated
- 2025/07/31
- Product number
- D6036
- Product name
- tert-Butyl 3-Formyl-1H-indole-1-carboxylate
- Packaging
- 25G
- Price
- $213
- Updated
- 2025/07/31
- Product number
- B695270
- Product name
- tert-Butyl3-Formyl-1H-indole-1-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W7085
- Product name
- 1-Boc-3-Formylindole
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE Chemical Properties,Usage,Production
Uses
3-Formylindole-1-carboxylic acid t-butyl ester is a carboxylic acid ester derivative that can be used as an intermediate in organic synthesis.
Synthesis
487-89-8
24424-99-5
57476-50-3
GENERAL METHOD: 3-indolecarboxaldehyde, triethylamine (1.3 eq.) and 10 mol% DMAP were dissolved in dichloromethane and di-tert-butyl dicarbonate (1.2 eq.) was added slowly. The reaction mixture was stirred at room temperature until complete consumption of the ingredients was shown by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and subsequently washed with water. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent ratio: ethyl acetate/hexane = 1:5 for 1a and 1b; ethyl acetate/hexane = 1:9 for 1c) to afford the target compounds tert-butyl 3-formyl-1H-indole-1-carboxylate (1a-1c).
References
[1] Synthetic Communications, 2000, vol. 30, # 12, p. 2143 - 2159
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 22, p. 7904 - 7912
[3] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 2, p. 357 - 358
[4] Journal of Organic Chemistry, 2016, vol. 81, # 4, p. 1723 - 1730
[5] Journal of the American Chemical Society, 2018, vol. 140, # 20, p. 6432 - 6440
TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE Suppliers
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View Lastest Price from TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE manufacturers
- Product
- TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE 57476-50-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-23