ChemicalBook > CAS DataBase List > INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER

INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER

Product Name
INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
CAS No.
338760-26-2
Chemical Name
INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
Synonyms
METHYL 1-BOC-1H-INDOLE-3-CARBOXYLATE;tert-butyl methyl 1H-indole-1,3-dicarboxylate;1-tert-Butyl 3-Methyl 1H-indole-1,3-dicarboxylate;methyl 1-tert-butoxycarbonyl-1H-indole-3-carboxylate;INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER;1H-Indole-1,3-dicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
CBNumber
CB0103868
Molecular Formula
C15H17NO4
Formula Weight
275.3
MOL File
338760-26-2.mol
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INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Property

Melting point:
127.0 °C
Boiling point:
387.3±34.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB139922
Product name
1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
Packaging
250mg
Price
$87.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139922
Product name
1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
Packaging
500mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
Z4617
Product name
1-tert-Butyl3-methyl1H-indole-1,3-dicarboxylate
Packaging
250mg
Price
$168
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139922
Product name
1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
Packaging
1g
Price
$265
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139922
Product name
1-tert-Butyl 3-methyl 1H-indole-1,3-dicarboxylate
Packaging
2g
Price
$460
Updated
2021/12/16
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INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Chemical Properties,Usage,Production

Synthesis

942-24-5

24424-99-5

338760-26-2

Methyl indole-3-carboxylate (17.1 mmol) was placed in a 50 mL round-bottomed flask, NaH (1.5 eq.) was added and cooled under ice bath conditions. THF (20 mL) was added slowly and stirred for 30 minutes. Subsequently, di-tert-butyl dicarbonate (1.5 eq.) was added and the reaction continued to stir overnight. Upon completion of the reaction, the reaction was quenched with saturated NaHCO3 solution, the reaction mixture was diluted with ether and washed with water. The organic layer was dried with anhydrous Na2SO4 and concentrated. The crude product was purified by column chromatography (ethyl acetate/hexane as eluent) to give 3-methyl-1H-indole-1,3-dicarboxylic acid-1-tert-butyl ester in 98% yield.

References

[1] Patent: US2009/215828, 2009, A1. Location in patent: Page/Page column 13
[2] Patent: WO2009/103552, 2009, A1. Location in patent: Page/Page column 31
[3] Research on Chemical Intermediates, 2017, vol. 43, # 3, p. 1355 - 1363
[4] Tetrahedron, 2003, vol. 59, # 6, p. 747 - 754
[5] Chemistry - A European Journal, 2010, vol. 16, # 48, p. 14534 - 14544

INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER Suppliers

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338760-26-2, INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTERRelated Search:

Indole METHYL 1-BOC-1H-PYRROLE-3-CARBOXYLATE INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER 1-(TERT-BUTOXYCARBONYL)-1H-INDOLE-3-CARBOXYLIC ACID TERT-BUTYL 3-FORMYL-1H-INDOLE-1-CARBOXYLATE 3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • INDOLE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER
  • METHYL 1-BOC-1H-INDOLE-3-CARBOXYLATE
  • 1H-Indole-1,3-dicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
  • 1-tert-Butyl 3-Methyl 1H-indole-1,3-dicarboxylate
  • methyl 1-tert-butoxycarbonyl-1H-indole-3-carboxylate
  • tert-butyl methyl 1H-indole-1,3-dicarboxylate
  • 338760-26-2