THEBAINE
- Product Name
- THEBAINE
- CAS No.
- 115-37-7
- Chemical Name
- THEBAINE
- Synonyms
- Tebain;C06173;Thebain;THEBAINE;Thenaine;p-Morphine;(-)-thebain;PARAMORPHINE;thebaine (90%);Thebaine (CRM)
- CBNumber
- CB4404547
- Molecular Formula
- C19H21NO3
- Formula Weight
- 311.37
- MOL File
- 115-37-7.mol
THEBAINE Property
- Melting point:
- 183-186°C (dec.)
- alpha
- D15 -219° (p = 2 in alc); D23 -230° (p = 5 in chloroform)
- Boiling point:
- 451.42°C (rough estimate)
- Density
- 1.3050
- refractive index
- 1.5000 (estimate)
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- H2O: 2.2 mg/mL, slightly soluble
- form
- powder
- pka
- 6.05(at 15℃)
- Water Solubility
- <10mg/L(room temperature)
- EPA Substance Registry System
- Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-,(5.alpha.)- (115-37-7)
Safety
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 1544 6.1/PG 2
- WGK Germany
- 3
- RTECS
- QD2975000
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T2019
- Product name
- Thebaine
- Purity
- powder
- Packaging
- 1G
- Price
- $239
- Updated
- 2024/03/01
- Product number
- 22024
- Product name
- Thebaine (CRM)
- Packaging
- 1mg
- Price
- $24
- Updated
- 2023/06/20
- Product number
- 14043
- Product name
- Thebaine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $21
- Updated
- 2022/04/27
- Product number
- 14043
- Product name
- Thebaine
- Packaging
- 5mg
- Price
- $94
- Updated
- 2022/04/27
- Product number
- MT-59378
- Product name
- Thenaine
- Purity
- 98%
- Packaging
- 10g
- Price
- $350
- Updated
- 2021/12/16
THEBAINE Chemical Properties,Usage,Production
Description
The naturally occurring opiate alkaloid thebaine is present in high concentrations in poppy straw; lower concentrations of the co deine alkaloid are present.
Description
Thebaine (Item No. 14043) is an analytical reference material categorized as a precursor in the synthesis of morphine (Item Nos. ISO60147 | 15464) and codeine (Item Nos. ISO60140 | 15459). Thebaine is a potential impurity in the illicit synthesis of heroin (Item Nos. ISO60187 | 9001543 | 9003076). Thebaine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical Properties
Tan Solid
Uses
Controllled substance (opiate).
Uses
Thebaine is present in opium at 0.3–1.5%.It is extracted from opium or from latex ofthe plant Papaver bracteatum, in which it ispresent at up to 26%. It is used to producecodeine.
Uses
Thebaine is used in the manufacture of other opiate pharmaceuticals, such as bupren and morphine, and caused contact dermatitis in a laboratory worker at an opiate-manufacturing pharmaceutical company, who was also sensitive to co deine.
Definition
ChEBI: Thebaine is a morphinane alkaloid and an organic heteropentacyclic compound. It is a conjugate base of a thebaine(1+).
Hazard
Toxic by ingestion, may induce addiction.
Health Hazard
Although thebaine has a morphine- orcodeine-like structure, its pharmacologyaction is somewhat different. It is a convulsantpoison like strychnine, rather thana narcotic. High doses can cause ataxia andconvulsion
LD50 value, intraperitoneal (mice): 42 mg/kg
Thebaine is a habit-forming compound. Itis a controlled substance (opiate) listed underU.S. Code of Federal Regulations (Title 21Part 1308.12, 1985).
Contact allergens
The naturally occurring opiate alkaloid thebaine is present in concentrated poppy straw, and in small concentrations in codeine alkaloid. It is used in the manufacture of other opiate pharmaceuticals, such as buprenorphine and morphine, and caused contact dermatitis in a laboratory worker at an opiates manufacturing pharmaceutical company, also sensitive to codeine.
Purification Methods
Crystallise Thebaine from Et2O or EtOH. Sublime it at 170-180o. The hydrochloride decomposes >182o (from MeOH/Et2O). [Beilstein 27 II 177, 27 III/IV 2271.] It is a NARCOTIC.
References
Pelletier, Thiboumery., Annalen, 16,38 (1835)
Kane., ibid, 19, 9 (1836)
Anderson., ibid, 86, 184 (1853)
Howerd., Ber., 17,527 (1884)
Pschorr, Zeidler., ibid, 27,2961 (1894)
Freund, Michaels, Gobel., ibid, 30, 1357 (1897)
Knorr., ibid, 36, 3074 (1903)
Freund, Holthof., ibid, 37, 2780 (1904)
Pschorr, Pfaff, Herrschmann., ibid, 38, 3163 (1905)
Reichard., Pharm. Zeit., 47,623 (1906)
Hildebrandt., Arch. expo Path. Pharm., 65,54 (1911)
Kruger, Eddy, Sumwalt., Suppl. No. 165, Public Health Reports, Washington
(1943)
Flieschhacker, Pasal, Vieboeck., Monatsh., 99, 300 (1968)
Eppenberger, Warren, Repoport., Helv. Chim. Acta, 51,381 (1968)