2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE

2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Property

Melting point:

169-171 °C(lit.)

Boiling point:

389.8±17.0 °C(Predicted)

Density 

1.389±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.95±0.10(Predicted)

form 

Powder

color 

White to off-white

λmax

232nm(phosphate buffer sol.)(lit.)

BRN 

153889

LogP

3.411 (est)

CAS DataBase Reference

2103-99-3(CAS DataBase Reference)

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38

Safety Statements 

26-36-36/37/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

XJ1026732

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

29341000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

2-Amino-4-(4-chlorophenyl)thiazole was used in the preparation of 2-chloroacetamido-4-(4-chlorophenyl)thiazole.

Synthesis

GENERAL METHOD: A mixture of thiourea (1.2 mmol) and α-bromo-4-chloroacetophenone (1 mmol) in ethanol (2 mL) was stirred and reacted at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water, filtered to collect the precipitate precipitated, and dried to obtain the target product 2-amino-4-(4-chlorophenyl)thiazole. The product yields and physical properties were as follows: [6a (99% yield), white solid, melting point 150-152 °C (literature value 26: 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 26: 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 26: 180-181 °C); 6d (98% yield), white solid, melting point 203.6-204.2 °C (literature value 28/22: 204.0-204.5 °C); 6e (94% yield), bright yellow solid, melting point 287-288 °C (literature values 26,27: 285-286 °C); 6f (100% yield), white solid, melting point 172-174°C (literature values 29-31: 172°C).

References

[1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Chinese Chemical Letters, 2014, vol. 25, # 1, p. 172 - 175
[3] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8099 - 8109
[4] Molecules, 2017, vol. 22, # 5,
[5] Synthetic Communications, 2009, vol. 39, # 16, p. 2895 - 2906