1H-Indazol-5-ol

Product Name: 1H-Indazol-5-ol
CAS No.: 15579-15-4
Chemical Name: 1H-Indazol-5-ol
Synonyms: 5-hydroxyindazole;1H-INDAZOL-5-OL;5-HYDROXY (1H)INDAZOLE;5-Hydroxy-1H-indazole 97%;5-Hydroxy-1H-indazole, 97+%;5-Hydroxy-1H-indazole;1H-Indazol-5-ol (6CI, 8CI, 9CI, ACI)
CBNumber: CB4405261
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 15579-15-4.mol

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1H-Indazol-5-ol Property

Melting point:: 186-191°C
Boiling point:: 366.5±15.0 °C(Predicted)
Density: 1.434±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 9.22±0.40(Predicted)
color: White to Light yellow
InChI: InChI=1S/C7H6N2O/c10-6-1-2-7-5(3-6)4-8-9-7/h1-4,10H,(H,8,9)
InChIKey: ZHDXWEPRYNHNDC-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(O)C=C2)C=N1
CAS DataBase Reference: 15579-15-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 717126
Product name: 5-Hydroxy-1H-indazole
Purity: 97%
Packaging: 1g
Price: $118
Updated: 2023/06/20

TCI Chemical

Product number: H1636
Product name: 5-Hydroxy-1H-indazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: H1636
Product name: 5-Hydroxy-1H-indazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $211
Updated: 2025/07/31

TRC

Product number: H825705
Product name: 5-Hydroxy-1H-indazole
Packaging: 1g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 069756
Product name: 5-Hydroxy-1H-indazole
Purity: 98%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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1H-Indazol-5-ol Chemical Properties,Usage,Production

Uses

5-Hydroxy-1H-indazole is a possible Rho kinase inhibitor. It is also used to discover (sulfamoylphenyl)indazolyl acetamides and carboxamides as inhibitors of mitotic kinase TTK.

Synthesis

94444-96-9

15579-15-4

General procedure for the synthesis of 1H-indazol-5-ol using 5-methoxy-1H-indazole as starting material: a dichloromethane solution of boron tribromide (18.5 mL, 18.5 mmol) was slowly added dropwise to a solution of 5-methoxy-1H-indazole (1.24 g, 8.40 mmol) in dichloromethane (84 mL) at 0 °C. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirred continuously for 10 hours. Upon completion of the reaction, the reaction solution was poured into an ice water bath and subsequently extracted with ethyl acetate. The organic phases were combined and washed sequentially with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: chloroform/methanol=96/4, v/v) to afford 1H-indazol-5-ol (877 mg, 71% yield) as a white solid. The structure of the product was confirmed by 1H-NMR (DMSO-d6): δ 6.88 (1H, dd, J = 8.8, 2.2 Hz), 6.96 (1H, d, J = 2.2 Hz), 7.34 (1H, d, J = 8.8 Hz), 7.84 (1H, s).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 44

1H-Indazol-5-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indazol-5-ol Suppliers

Americas 1 China 203 Europe 1 Germany 3 India 4 Japan 1 United Kingdom 3 United States 27 Global 243

Nanjing Puxin Pharmaceutical Technology Co., Ltd

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Energy Chemical

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View Lastest Price from 1H-Indazol-5-ol manufacturers

INNOBIO PHARM CO.,LTD

Product: 1H-indazol-5-ol 15579-15-4
Price: US $0.00-0.00/KG
Min. Order: 5KG
Purity: 98%
Supply Ability: 5000kg
Release date: 2025-10-15

Hebei Fengjia New Material Co., Ltd

Product: 1H-Indazol-5-ol 15579-15-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-12

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1H-Indazol-5-ol 15579-15-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-14

15579-15-4, 1H-Indazol-5-olRelated Search:

Stanozolol Tebuconazole Cyproconazol Diniconazole Triadimenol CHLOROPHOSPHONAZO III Hexaconazole 5-Benzyloxy-1H-indazole-3-carboxylic acid METHYL 5-METHOXY-1H-INDAZOLE-3-CARBOXYLATE 5-TRIFLUOROMETHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID 5-Methoxy-3-indazolecarboxylic acid 5-METHOXY-1H-INDAZOLE-3-CARBALDEHYDE 1H-INDAZOL-3-OL,1H-Indazol-3-ol ,97% 1-BENZYL-1H-INDAZOL-3-OL 1H-Indazol-4-ol ,97% 1H-INDAZOL-3-OL 5,6-DIMETHOXY-1H-INDAZOLE-3-CARBONITRILE 5,6-DIMETHOXY-1H-INDAZOLE

5-HYDROXY (1H)INDAZOLE

1H-INDAZOL-5-OL

5-hydroxyindazole

5-Hydroxy-1<i>H-</i>indazole

5-Hydroxy-1H-indazole 97%

5-Hydroxy-1H-indazole, 97+%

1H-Indazol-5-ol (6CI, 8CI, 9CI, ACI)

15579-15-4

pharmacetical

Alcohols and Derivatives

Heterocycles