4-HYDROXYINDAZOLE
Uses- Product Name
- 4-HYDROXYINDAZOLE
- CAS No.
- 81382-45-8
- Chemical Name
- 4-HYDROXYINDAZOLE
- Synonyms
- 1H-Indazol-4-ol;4-HYDROXYINDAZOLE;1H-Indazol-4-ol ,97%;4-Hydroxy-1H-indazole;4-Hydroxyindazole HCl;4-HYDROXYL (1H)INDAZOLE;4-Hydroxyindazole hydrochloride;1,2-dihydroindazol-4-one hydrochloride
- CBNumber
- CB5254031
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 81382-45-8.mol
4-HYDROXYINDAZOLE Property
- Melting point:
- 177-178℃
- Boiling point:
- 366.5±15.0 °C(Predicted)
- Density
- 1.434±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.76±0.40(Predicted)
- Appearance
- Light yellow to green yellow Solid
Safety
- Risk Statements
- 20/21/22
- Safety Statements
- 24/25-36/37
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- A416355
- Product name
- 4-Hydroxyindazole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A416355
- Product name
- 4-Hydroxyindazole
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- OR43567
- Product name
- 4-Hydroxy-1H-indazole
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H01-1-17
- Product name
- 1H-Indazol-4-ol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- Y5565
- Product name
- 1H-Indazol-4-ol
- Packaging
- 1g
- Price
- $197
- Updated
- 2021/12/16
4-HYDROXYINDAZOLE Chemical Properties,Usage,Production
Uses
4-Hydroxyinazole is a heterocyclic compound mainly used in laboratory organic synthesis and chemical production processes.
Chemical Properties
White to off-white solid
Synthesis
41748-71-4
81382-45-8
C. General procedure for the preparation of 4-hydroxyindazole from 4-aminoindazole: 4-aminoindazole (9.6 g, 0.072 mol) was dissolved in a glass reaction vessel containing 7.2 g of concentrated sulfuric acid in 75 mL of water. The mixture was transferred to a stainless steel autoclave, sealed and heated to 170°C for overnight reaction. Upon completion of the reaction, a large amount of black precipitate appeared in the reaction mixture. The reaction mixture was diluted with ethyl acetate and water and transferred to a dispensing funnel for distribution. The aqueous layer was extracted with ethyl acetate several times until 4-hydroxyindazole was completely transferred to the organic phase. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give a dark brown or black oil. The crude product was purified by silica gel column chromatography with an eluent of 50% ethyl acetate/hexane mixture to give 4-hydroxyindazole as an off-white solid (3.3 g, 33% yield).
References
[1] Patent: WO2004/39796, 2004, A1. Location in patent: Page/Page column 71-72
[2] Patent: US6534504, 2003, B1
[3] Patent: US6841563, 2005, B1. Location in patent: Page column 20
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 8, p. 3975 - 3991
[5] Journal of the Chemical Society, 1955, p. 2412,2419
4-HYDROXYINDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-HYDROXYINDAZOLE manufacturers
- Product
- 4-Hydroxyindazole 81382-45-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09