4-Methoxyindazole-3-carboxylic acid
- Product Name
- 4-Methoxyindazole-3-carboxylic acid
- CAS No.
- 865887-02-1
- Chemical Name
- 4-Methoxyindazole-3-carboxylic acid
- Synonyms
- 4-METHOXYINDAZOLE-3-CARBOXYLIC ACID;4-METHOXY-1H-INDAZOLE-3-CARBOXYLIC ACID;1H-Indazole-3-carboxylic acid, 4-methoxy-
- CBNumber
- CB3707144
- Molecular Formula
- C9H8N2O3
- Formula Weight
- 192.17
- MOL File
- 865887-02-1.mol
4-Methoxyindazole-3-carboxylic acid Property
- Boiling point:
- 467.6±25.0 °C(Predicted)
- Density
- 1.459±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.85±0.40(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M269578
- Product name
- 4-Methoxy-1H-indazole-3-carboxylicAcid
- Packaging
- 25mg
- Price
- $695
- Updated
- 2021/12/16
- Product number
- OR922400
- Product name
- 4-Methoxy-1H-indazole-3-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 124856
- Product name
- 4-Methoxyindazole-3-carboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1073
- Updated
- 2021/12/16
- Product number
- CHM0094260
- Product name
- 1H-INDAZOLE-3-CARBOXYLIC ACID,4-METHOXY-
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1273.39
- Updated
- 2021/12/16
- Product number
- 3579AC
- Product name
- 4-Methoxy-1H-indazole-3-carboxylicacid
- Packaging
- 1g
- Price
- $1498
- Updated
- 2021/12/16
4-Methoxyindazole-3-carboxylic acid Chemical Properties,Usage,Production
Uses
4-Methoxy-1H-indazole-3-carboxylic Acid is used in the preparation of tricyclic compounds such as alpha-7 nicotinic acetylcholine receptor ligands for treatment of central nervous system disorders.
Synthesis
108937-87-7
865887-02-1
The general procedure for the synthesis of 4-methoxy-1H-indazole-3-carboxylic acid from 4-methoxyindoline-2,3-dione was as follows: 4-methoxyindoline-2,3-dione (20.7 mmol) was mixed with 1M sodium hydroxide solution (23 mL) and the reaction mixture was heated to 30-40 °C and maintained at this temperature for 30 minutes. Subsequently, the reaction mixture was cooled to 0 °C and treated with an aqueous solution (5.1 mL) of sodium nitrite (20.7 mmol) and maintained for 20 minutes. This solution was slowly added dropwise to a mixture of concentrated sulfuric acid (2.24 mL) and water (43.3 mL) that had been pre-cooled to 0-5 °C, and the reaction mixture was kept at 0-5 °C for 0.5 hours. Next, a concentrated hydrochloric acid (19.6 mL) solution of tin(II) chloride (50.5 mmol) was added drop by drop and the reaction mixture was kept at 0-5 °C for 1 hour. Upon completion of the reaction, the precipitated solid was separated by filtration and dried to afford 4-methoxy-1H-indazole-3-carboxylic acid as a yellow solid (100% yield).
References
[1] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 67
4-Methoxyindazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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