10-PROPOXY-DECANOIC ACID
- Product Name
- 10-PROPOXY-DECANOIC ACID
- CAS No.
- 119290-12-9
- Chemical Name
- 10-PROPOXY-DECANOIC ACID
- Synonyms
- O-11;O11,O 11;10-PROPOXY-DECANOIC ACID;11-OXATETRADECANOIC ACID;Decanoic acid, 10-propoxy-;HSRAJJQTYQHRSA-UHFFFAOYSA-N;10-(propoxy)decanoyl-coenzyme A
- CBNumber
- CB4408954
- Molecular Formula
- C13H26O3
- Formula Weight
- 230.34
- MOL File
- 119290-12-9.mol
10-PROPOXY-DECANOIC ACID Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 90510
- Product name
- O-11
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 90510
- Product name
- O-11
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 90510
- Product name
- O-11
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $371
- Updated
- 2024/03/01
- Product number
- 1138AH
- Product name
- 10-Propoxy-decanoicacid
- Packaging
- 10mg
- Price
- $510
- Updated
- 2021/12/16
10-PROPOXY-DECANOIC ACID Chemical Properties,Usage,Production
Definition
ChEBI: 10-propoxydecanoic acid is a medium-chain fatty acid.
Biological Activity
O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 μM in a cell culture assay.1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1 O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3
References
1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)
10-PROPOXY-DECANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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