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ATRACTYLOSIDE POTASSIUM SALT

Product Name
ATRACTYLOSIDE POTASSIUM SALT
CAS No.
102130-43-8
Chemical Name
ATRACTYLOSIDE POTASSIUM SALT
Synonyms
ATR, 2K;bis(potassium salt);Atractyloside dipotassium;ATRACTYLOSIDE POTASSIUM SALT;ATRACTYLOSIDE, DIPOTASSIUM SALT;Atractylic acid dipotassium salt;Atractyloside dipotassium salt, >=98%;ATRACTYLOSIDE POTASSIUM SALT USP/EP/BP;Atractyloside potassium salt, 10 mM in DMSO;ATRACTYLOSIDE, DIPOTASSIUM SALT, ATRACTYLIS GUMMIFERA
CBNumber
CB9377631
Molecular Formula
C30H47KO16S2
Formula Weight
766.91
MOL File
102130-43-8.mol
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ATRACTYLOSIDE POTASSIUM SALT Property

Melting point:
234-238°C
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O: 20 mg/mL
form 
Solid
color 
Pale Brown to Pale Beige
Stability:
Hygroscopic
InChIKey
VFOXXOVBJAYRTD-GYBHJGEKNA-N
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2938909090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14804
Product name
Atractyloside (potassium salt)
Purity
≥95%
Packaging
500μg
Price
$119
Updated
2024/03/01
Cayman Chemical
Product number
14804
Product name
Atractyloside (potassium salt)
Purity
≥95%
Packaging
1mg
Price
$225
Updated
2024/03/01
TRC
Product number
A794588
Product name
AtractylosideDipotassiumSalt
Packaging
2.5mg
Price
$85
Updated
2021/12/16
Usbiological
Product number
292600
Product name
Atractyloside Dipotassium salt
Packaging
1mg
Price
$410
Updated
2021/12/16
ChemScene
Product number
CS-0016909
Product name
Atractylosidepotassiumsalt
Purity
99.93%
Packaging
5mg
Price
$350
Updated
2021/12/16
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ATRACTYLOSIDE POTASSIUM SALT Chemical Properties,Usage,Production

Description

Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera. Atractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Xanthium sibiricum, Atractylodes lancea, and Atractylodes macrocephala.

Uses

Atractyloside Dipotassium Salt is an inhibitor of ANT and apoptosis inducer.

in vivo

Atractyloside (2-4 mg/kg, i.p., 2 weeks before feeding duration ends) potassium salt protects mice against liver steatosis by activation of autophagy via ANT-AMPK-mTORC1 signaling pathway[13].
Atractyloside (50 mg/kg, i.p.) potassium salt produces a tubular nephrosis 180 min after its administration in male albino rats[14].

Animal Model:Male ICR wide-type (WT) mice (feed with a high-fat diet (HFD))[13]
Dosage:2, 4 mg/kg
Administration:Intraperitoneal injection (i.p.), 2 weeks before the feeding duration ends
Result:Reversed the changes of body weight, RW of liver and epididymal fat, and the serum AST level.
Improved the NAFLD steatosis and decrease HFD-induced lipid accumulation in the liver.
Decreased the protein expression of p-mTOR and the value of p-mTOR/mTOR.
Increased the protein expression of LC3A/B-Ⅱ and ATG7.
Increased amount of colocalization of LC3B and PLIN2.

References

[1]. yamaguchi n, kagari t, kasai m. inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an adp/atp translocase inhibitor, atractyloside. biochem biophys res commun, 1999, 258(2): 247-251.
[2]. pick-kober kh, schneider f. proliferation, macromolecular synthesis and energy metabolism of in vitro grown ehrlich ascites tumor cells after inhibition of atp-adp translocation by atractyloside. eur j cell biol, 1984, 34(2): 323-329.
[3]. malekova l, kominkova v, ferko m, et al. bongkrekic acid and atractyloside inhibits chloride channels from mitochondrial membranes of rat heart. biochim biophys acta, 2007, 1767(1): 31-44.

ATRACTYLOSIDE POTASSIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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ATRACTYLOSIDE POTASSIUM SALT Suppliers

China 170 Japan 1 Switzerland 2 United Kingdom 4 United States 19 Global 196
Jiangxi Baicaoyuan Biotechnology Co. , Ltd.
Tel
0791-82165230 17707911324
Email
2279635539@qq.com
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China
ProdList
1387
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58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
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60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
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58
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Fax
QQ：190129269
Email
winherb@126.com
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China
ProdList
1245
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58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
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66
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
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58
Cheng Du Pufeide Biotechnology Co., Ltd.
Tel
028-82610909 13388174823
Fax
8171-1798
Email
scglp@glp-china.com
Country
China
ProdList
1064
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58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
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View Lastest Price from ATRACTYLOSIDE POTASSIUM SALT manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Atractyloside potassium salt 102130-43-8
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-01-09
Career Henan Chemical Co
Product
ATRACTYLOSIDE POTASSIUM SALT 102130-43-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

102130-43-8, ATRACTYLOSIDE POTASSIUM SALTRelated Search:

N-OCTYL ALPHA-D-GLUCOPYRANOSIDE Undecenoic acid ETHYL POTASSIUM SULFATE 16-HYDROXYHEXADECANOIC ACID 12-TRIDECANOIC ACID 4-CYCLOHEXYLBUTYRIC ACID CYCLOPENTADECANOL ATRACTYLOSIDE POTASSIUM SALT Cyclohexylacetic acid CYCLOPENTADECANE ATRACTYLOSIDE SODIUM SALT ATRACTYLOSIDE POTASSIUM SALT(RG) 1-CYCLOHEXYL-2-PROPEN-1-OL 14-Pentadecenoicacid 3-METHOXYCYCLOHEXANECARBOXYLIC ACID TRANS-(4-METHYL-CYCLOHEXYL)-ACETIC ACID 2-cyclohexylbutyric acid 4-METHYLCYCLOHEXANEACETIC ACID

  • ATR, 2K
  • ATRACTYLOSIDE, DIPOTASSIUM SALT
  • ATRACTYLOSIDE, DIPOTASSIUM SALT, ATRACTYLIS GUMMIFERA
  • ATRACTYLOSIDE POTASSIUM SALT
  • 19-Norkaur-16-en-18-oic acid, 15-hydroxy-2-2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-.beta.-D-glucopyranosyloxy-, dipotassium salt, (2.beta.,15.alpha.)-
  • (2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic acid dipotassium salt
  • 19-Norkaur-16-en-18-oicacid, 15-hydroxy-2-[[2-O-(3-Methyl-1-oxobutyl)-3,4-di-O-sulfo-b-D-glucopyranosyl]oxy]-,dipotassiuM salt, (2b,15a)- (9CI)
  • Atractyloside dipotassium salt, >=98%
  • (2β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Dipotassium Salt
  • 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene
  • Atractyloside dipotassium
  • ATRACTYLOSIDE POTASSIUM SALT USP/EP/BP
  • (1S,4R,7R,9S,10S,13R,15S)-15-hydroxy-7-[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3-(3-methylbutanoyloxy)-4,5-disulfooxy-tetrahydropyran-2-yl]oxy-9-methyl-14-methylene-tetracyclo[11.2.1.011o.0??]hexadecane-5-carboxylic acid
  • bis(potassium salt)
  • Potassium (2R,4aR,6aR,7S,9R,11aS,11bR)-7-hydroxy-2-(((2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3-((3-methylbutanoyl)oxy)-5-(sulfonatooxy)-4-(sulfooxy)tetrahydro-2H-pyran-2-yl)oxy)-11b-methyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carbox
  • Atractylic acid dipotassium salt
  • Atractyloside potassium salt, 10 mM in DMSO
  • 102130-43-8
  • C30H44O16S22K
  • C30H44O16S2K2
  • reagent
  • standard substance
  • chemical reagent
  • herbal extract
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • Cell Stress
  • Mitochondrial Inhibitors
  • Nitric Oxide and Cell Stress