ATRACTYLOSIDE POTASSIUM SALT

Product Name: ATRACTYLOSIDE POTASSIUM SALT
CAS No.: 102130-43-8
Chemical Name: ATRACTYLOSIDE POTASSIUM SALT
Synonyms: ATR, 2K;bis(potassium salt);Atractyloside dipotassium;ATRACTYLOSIDE POTASSIUM SALT;ATRACTYLOSIDE, DIPOTASSIUM SALT;Atractylic acid dipotassium salt;Atractyloside dipotassium salt, >=98%;ATRACTYLOSIDE POTASSIUM SALT USP/EP/BP;Atractyloside potassium salt, 10 mM in DMSO;ATRACTYLOSIDE, DIPOTASSIUM SALT, ATRACTYLIS GUMMIFERA
CBNumber: CB9377631
Molecular Formula: C30H47KO16S2
Formula Weight: 766.91
MOL File: 102130-43-8.mol

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ATRACTYLOSIDE POTASSIUM SALT Property

Melting point:: 234-238°C
storage temp.: Sealed in dry,2-8°C
solubility: H₂O: 20 mg/mL
form: Solid
color: Pale Brown to Pale Beige
Stability:: Hygroscopic
InChIKey: VFOXXOVBJAYRTD-GYBHJGEKNA-N

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 2938909090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14804
Product name: Atractyloside (potassium salt)
Purity: ≥95%
Packaging: 500μg
Price: $119
Updated: 2024/03/01

Cayman Chemical

Product number: 14804
Product name: Atractyloside (potassium salt)
Purity: ≥95%
Packaging: 1mg
Price: $225
Updated: 2024/03/01

TRC

Product number: A794588
Product name: AtractylosideDipotassiumSalt
Packaging: 2.5mg
Price: $85
Updated: 2021/12/16

Usbiological

Product number: 292600
Product name: Atractyloside Dipotassium salt
Packaging: 1mg
Price: $410
Updated: 2021/12/16

ChemScene

Product number: CS-0016909
Product name: Atractylosidepotassiumsalt
Purity: 99.93%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

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ATRACTYLOSIDE POTASSIUM SALT Chemical Properties,Usage,Production

Description

Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera. Atractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Xanthium sibiricum, Atractylodes lancea, and Atractylodes macrocephala.

Uses

Atractyloside Dipotassium Salt is an inhibitor of ANT and apoptosis inducer.

in vivo

Atractyloside (2-4 mg/kg, i.p., 2 weeks before feeding duration ends) potassium salt protects mice against liver steatosis by activation of autophagy via ANT-AMPK-mTORC1 signaling pathway^[13].
Atractyloside (50 mg/kg, i.p.) potassium salt produces a tubular nephrosis 180 min after its administration in male albino rats^[14].

Animal Model:	Male ICR wide-type (WT) mice (feed with a high-fat diet (HFD))^[13]
Dosage:	2, 4 mg/kg
Administration:	Intraperitoneal injection (i.p.), 2 weeks before the feeding duration ends
Result:	Reversed the changes of body weight, RW of liver and epididymal fat, and the serum AST level. Improved the NAFLD steatosis and decrease HFD-induced lipid accumulation in the liver. Decreased the protein expression of p-mTOR and the value of p-mTOR/mTOR. Increased the protein expression of LC3A/B-Ⅱ and ATG7. Increased amount of colocalization of LC3B and PLIN2.

References

[1]. yamaguchi n, kagari t, kasai m. inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an adp/atp translocase inhibitor, atractyloside. biochem biophys res commun, 1999, 258(2): 247-251.
[2]. pick-kober kh, schneider f. proliferation, macromolecular synthesis and energy metabolism of in vitro grown ehrlich ascites tumor cells after inhibition of atp-adp translocation by atractyloside. eur j cell biol, 1984, 34(2): 323-329.
[3]. malekova l, kominkova v, ferko m, et al. bongkrekic acid and atractyloside inhibits chloride channels from mitochondrial membranes of rat heart. biochim biophys acta, 2007, 1767(1): 31-44.

ATRACTYLOSIDE POTASSIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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ATRACTYLOSIDE POTASSIUM SALT Suppliers

China 170 Japan 1 Switzerland 2 United Kingdom 4 United States 19 Global 196

BIOSYNTH AG

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Email: welcome@biosynth.ch
Country: Switzerland
ProdList: 1308
Advantage: 60

SIGMA-RBI

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Country: Switzerland
ProdList: 6896
Advantage: 91

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View Lastest Price from ATRACTYLOSIDE POTASSIUM SALT manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Atractyloside potassium salt 102130-43-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-01-09

Career Henan Chemical Co

Product: ATRACTYLOSIDE POTASSIUM SALT 102130-43-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-11

102130-43-8, ATRACTYLOSIDE POTASSIUM SALTRelated Search:

N-OCTYL ALPHA-D-GLUCOPYRANOSIDE Undecenoic acid ETHYL POTASSIUM SULFATE 16-HYDROXYHEXADECANOIC ACID 12-TRIDECANOIC ACID 4-CYCLOHEXYLBUTYRIC ACID CYCLOPENTADECANOL ATRACTYLOSIDE POTASSIUM SALT Cyclohexylacetic acid CYCLOPENTADECANE ATRACTYLOSIDE SODIUM SALT ATRACTYLOSIDE POTASSIUM SALT(RG) 1-CYCLOHEXYL-2-PROPEN-1-OL 14-Pentadecenoicacid 3-METHOXYCYCLOHEXANECARBOXYLIC ACID TRANS-(4-METHYL-CYCLOHEXYL)-ACETIC ACID 2-cyclohexylbutyric acid 4-METHYLCYCLOHEXANEACETIC ACID

ATR, 2K

ATRACTYLOSIDE, DIPOTASSIUM SALT

ATRACTYLOSIDE, DIPOTASSIUM SALT, ATRACTYLIS GUMMIFERA

ATRACTYLOSIDE POTASSIUM SALT

19-Norkaur-16-en-18-oic acid, 15-hydroxy-2-2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-.beta.-D-glucopyranosyloxy-, dipotassium salt, (2.beta.,15.alpha.)-

(2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic acid dipotassium salt

19-Norkaur-16-en-18-oicacid, 15-hydroxy-2-[[2-O-(3-Methyl-1-oxobutyl)-3,4-di-O-sulfo-b-D-glucopyranosyl]oxy]-,dipotassiuM salt, (2b,15a)- (9CI)

Atractyloside dipotassium salt, >=98%

(2β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Dipotassium Salt

19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene

Atractyloside dipotassium

ATRACTYLOSIDE POTASSIUM SALT USP/EP/BP

(1S,4R,7R,9S,10S,13R,15S)-15-hydroxy-7-[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3-(3-methylbutanoyloxy)-4,5-disulfooxy-tetrahydropyran-2-yl]oxy-9-methyl-14-methylene-tetracyclo[11.2.1.011o.0??]hexadecane-5-carboxylic acid

bis(potassium salt)

Potassium (2R,4aR,6aR,7S,9R,11aS,11bR)-7-hydroxy-2-(((2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3-((3-methylbutanoyl)oxy)-5-(sulfonatooxy)-4-(sulfooxy)tetrahydro-2H-pyran-2-yl)oxy)-11b-methyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carbox

Atractylic acid dipotassium salt

Atractyloside potassium salt, 10 mM in DMSO

102130-43-8

C30H44O16S22K

C30H44O16S2K2

reagent

standard substance

chemical reagent

herbal extract

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

Cell Stress

Mitochondrial Inhibitors

Nitric Oxide and Cell Stress