H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH

Product Name: H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
CAS No.: 131334-43-5
Chemical Name: H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
Synonyms: MYELIN PROTEOLIPID PROTEIN (139-151);PLP (HUMAN, BOVINE, DOG, MOUSE, RAT);Myelin Proteolipid Protein (139-151) (1);6:PN:WO2012154215 SEQID:5 unclaimed protein;HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE;H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH;PLP (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT);MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT);LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT);MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)
CBNumber: CB4410067
Molecular Formula: C72H104N20O16S
Formula Weight: 1537.79
MOL File: 131334-43-5.mol

More

Less

H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH Property

Boiling point:: 1897.4±65.0 °C(Predicted)
Density: 1.332±0.06 g/cm3(Predicted)
pka: 3.49±0.10(Predicted)
form: White to off-white powder.
color: White to off-white
Sequence: H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0002557
Product name: MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT)
Purity: 95.00%
Packaging: 1MG
Price: $836.8
Updated: 2021/12/16

More

Less

H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH Chemical Properties,Usage,Production

Uses

PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

in vivo

PLP (139-151) can be used in animal modeling to create relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE) models. The pro-inflammatory cytokine IL-17 plays a crucial role in the PLP (139-151)-induced encephalomyelitis process. After subcutaneous injection of PLP (139-151) into mice, CD4 cells that specifically respond to PLP (139-151) and release pro-inflammatory cytokines migrate to and accumulate in the damaged central nervous system (CNS) regions^[4]^[5].

Induction of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (RR-EAE)

Background

Proinflammatory cytokines produced by neuroantigen-specific T cells are considered key factors in the initiation and maintenance of autoimmune encephalomyelitis. PLP (139-151) induces autoimmune encephalomyelitis by activating immune responses mediated by specific CD4 cells, which release proinflammatory cytokines such as IL-17 and IFN-γ. This leads to local inflammation and disruption of neural function, thereby inducing autoimmune encephalomyelitis^[5]^[6].

Specific Modeling Methods

Mice: SJL/J ? female ? 6-week-old
Administration: 100 μg ? sc ? single dose

Note

1. Subcutaneously inject 100 μg of PLP (139-151) (100 μl, 1 μg/μl) along with 100 μl of complete Freund's adjuvant (HY-153808) to enhance the mouse's immune response to PLP (139-151).
2. One day after the subcutaneous injection of PLP (139-151), perform an intraperitoneal injection of 100 μl (2 ng/μl, dissolved in phosphate-buffered saline (PBS)) of Bordetella pertussis toxin (BPX) to further enhance the mouse's immune response to PLP (139-151).
3. Monitor the mice daily for changes in body weight and clinical status. Perform neurological evaluations using a clinical score (CS) system with the following scale: 0 for no abnormalities; 0.5 for a drooping tail tip; 1 for a limp tail; 1.5 for hind limb dysfunction; 2 for hind limb weakness; 2.5 for dragging hind limbs; 3 for hind limb paralysis; 3.5 for complete hind limb paralysis with the mouse unable to right itself when placed on its side; and 4 for complete hind limb paralysis and partial front limb paralysis.
4. Isolate mice with early clinical symptoms of encephalomyelitis in separate cages with easier access to food and water. Dehydrated mice should receive an intraperitoneal injection of saline solution at least once a day.

Modeling Indicators

Phenotypic Observations: Resulted mouse weight loss and a significant increase in clinical scores.
Histological Changes: Resulted iron deposits in the cerebellum, medulla, and spinal cord of the mice.
Molecular Changes: Enhanced the immune signals of TSPO and Iba1 (markers of microglia and macrophage activation) in immunohistochemical results, indicating that microglia and macrophages were activated.

Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808); Bordetella pertussis toxin

Opposite Product(s): /

References

[1] Kuchroo VK, et al. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59(5):305-12. DOI:10.1159/000163668
[2] Sobel RA, et al. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide ofmyelin proteolipid protein. J Neuropathol Exp Neurol. 1990 Sep;49(5):468-79. DOI:10.1097/00005072-199009000-00002
[3] Bebo BF Jr, et al. Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res. 1996 Sep 15;45(6):680-9. DOI:10.1002/(SICI)1097-4547(19960915)45:63.0.CO;2-4
[4] Coda AR, et al. In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis. Eur J Nucl Med Mol Imaging. 2021 Jan;48(1):40-52. DOI:10.1007/s00259-020-04842-7
[5] Turvey ME, et al. Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis. J Proteome Res. 2014 Aug 1;13(8):3655-70. DOI:10.1021/pr500158r
[6] Zhang H, et al. Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J Immunol. 2008 Oct 1;181(7):4638-47. DOI:10.4049/jimmunol.181.7.4638

H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH Suppliers

China 51 France 1 Switzerland 1 United States 5 Global 58

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1010
Advantage: 55

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

More

Less

View Lastest Price from H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH manufacturers

Career Henan Chemical Co

Product: H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH 131334-43-5
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

131334-43-5, H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OHRelated Search:

Mog (35-55) Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA) PLP (139-151) H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH

MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)

MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN, BOVINE, DOG, MOUSE, RAT)

LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)

HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE

H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH

H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH (HUMAN, BOVINE, DOG, MOUSE, RAT)

PLP (139-151) (DEPALMITOYLATED) (HUMAN, BOVINE, DOG, MOUSE, RAT)

PLP (HUMAN, BOVINE, DOG, MOUSE, RAT)

MYELIN PROTEOLIPID PROTEIN (139-151)

Myelin Proteolipid Protein (139-151) (1)

Myelin Proteolipid Protein (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat) Lipophilin (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylat

Lipophilin (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), PLP (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat), Lipophilin (139-151) (depalMitoylated) (huMan, bovine, dog, Mouse, rat)

L-Phenylalanine,L-histidyl-L-cysteinyl-L-leucylglycyl-L-lysyl-L-tryptophyl-L-leucylglycyl-L-histidyl-L-prolyl-L-a-aspartyl-L-lysyl-

L-Phenylalanine, L-histidyl-L-cysteinyl-L-leucylglycyl-L-lysyl-L-tryptophyl-L-leucylglycyl-L-histidyl-L-prolyl-L-α-aspartyl-L-lysyl-

6:PN:WO2012154215 SEQID:5 unclaimed protein

PLP (139-151)|Myelin Proteolipid Protein (139-151))|(depMyelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)

131334-43-5

C72H104N20O16S