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Mog (35-55)

Product Name
Mog (35-55)
CAS No.
149635-73-4
Chemical Name
Mog (35-55)
Synonyms
MOG (35-55);MEVGWYRSPFSRVVHLYRNGK;MK21;MOG (35-55) TFA;MOG (35-55), RAT;MOG (MOUSE, RAT);MOG (35-55), MOUSE, RAT;MOG (RAT, MOUSE, 35-55);MOG (35-55) (rat, Mouse);H-MEVGWYRSPFSRVVHLYRNGK-OH
CBNumber
CB8355199
Molecular Formula
C118H177N35O29S
Formula Weight
2581.95
MOL File
149635-73-4.mol
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Mog (35-55) Property

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
≥32.25 mg/mL in H2O; insoluble in EtOH; ≥86 mg/mL in DMSO
form 
solid
color 
White to off-white
Water Solubility 
Soluble to 0.50 mg/ml in water
Sequence
H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-VAL-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
InChI
InChI=1/C118H177N35O29S/c1-61(2)47-80(103(169)143-81(49-66-30-34-70(156)35-31-66)104(170)139-75(26-17-42-129-116(122)123)99(165)145-86(53-90(121)158)98(164)133-56-91(159)136-79(115(181)182)25-15-16-41-119)142-108(174)85(52-69-55-128-60-135-69)147-112(178)95(63(5)6)152-113(179)96(64(7)8)151-101(167)77(28-19-44-131-118(126)127)141-109(175)87(58-154)148-106(172)83(48-65-21-11-10-12-22-65)146-110(176)89-29-20-45-153(89)114(180)88(59-155)149-100(166)76(27-18-43-130-117(124)125)140-105(171)82(50-67-32-36-71(157)37-33-67)144-107(173)84(51-68-54-132-74-24-14-13-23-72(68)74)137-92(160)57-134-111(177)94(62(3)4)150-102(168)78(38-39-93(161)162)138-97(163)73(120)40-46-183-9/h10-14,21-24,30-37,54-55,60-64,73,75-89,94-96,132,154-157H,15-20,25-29,38-53,56-59,119-120H2,1-9H3,(H2,121,158)(H,128,135)(H,133,164)(H,134,177)(H,136,159)(H,137,160)(H,138,163)(H,139,170)(H,140,171)(H,141,175)(H,142,174)(H,143,169)(H,144,173)(H,145,165)(H,146,176)(H,147,178)(H,148,172)(H,149,166)(H,150,168)(H,151,167)(H,152,179)(H,161,162)(H,181,182)(H4,122,123,129)(H4,124,125,130)(H4,126,127,131)/t73-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,94-,95-,96-/s3
InChIKey
JMTCEFUSRHYJBF-LTFOILMJNA-N
SMILES
N1(CCC[C@H]1C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1C=CC(=CC=1)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O)CC(N)=O)C(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1C=CC(=CC=1)O)NC(=O)[C@@H](NC(CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(O)=O)NC([C@H](CCSC)N)=O)=O)CC1C2C=CC=CC=2NC=1 |&1:4,8,19,25,36,43,50,60,68,80,91,99,114,120,131,143,150,157,165,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2568
Product name
MOG(35-55)
Packaging
1
Price
$229
Updated
2021/12/16
ApexBio Technology
Product number
A8306
Product name
MOG(35-55)
Packaging
1mg
Price
$98
Updated
2021/12/16
ApexBio Technology
Product number
A8306
Product name
MOG(35-55)
Packaging
5mg
Price
$294
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0003907
Product name
MOG (35-55)-MOUSE, RAT
Purity
95.00%
Packaging
1MG
Price
$733.72
Updated
2021/12/16
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Mog (35-55) Chemical Properties,Usage,Production

Description

MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.

Uses

Mog (35-55) can be used as an antigen immunized C57BL/6J mice to induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.

Biological Activity

mog (35-55) is a truncated peptide derived from the human myelin oligodendrocyte glycoprotein (mog). mog, a member of the immunoglobulin superfamily, is expressed wildly in the central nervous system. in mouse and rat models for human multiple sclerosis, mog is involved in inducing the experimental autoimmune encephalomyelitis. humoral auto-immunity to the myelin oligodendrocyte glycoprotein (mog) may be associated with the pathogenesis of multiple sclerosis (ms) [1].mog (35-55) is involved in inducing autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination [2]. in hla-dr2-transgenic mice, myelin oligodendrocyte glycoprotein-35-55 peptide induced severe chronic experimental autoimmune encephalomyelitis [3].mog35-55 was highly encephalitogenic and could induce strong t and b cell responses in rats [4]. in nod/lt mice (h-2g7) and c57bl/6 mice (h-2b), single injection of mog35-55 in cfa could induce ms-like disease [4].

in vivo

Myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 is one of the targets of self-reactive T cell responses, leading to acute and later chronic autoimmune processes. MOG 35-55 is capable of inducing experimental autoimmune encephalomyelitis (EAE) in B6 mice[1].

Induction of experimental autoimmune encephalomyelitis (EAE) model[3]
Background
Myelin Oligodendrocyte Glycoprotein Peptide (35-55) CAN trigger an immune response against the CNS, and induces inflammation and destruction of myelin or antigen-bearing structures that causes neurological abnormalities.
Specific Modeling Methods
Mice: C57BL/6 background mice ? 2-4 months old ? male and female
Administration: On day 0: 3 mg/mL peptide plus CFA (4 mg/mL) ? Mix thoroughly 1: 1 peptide and CFA solutions ? s.c. ? 100 μL for each hind flank; ? On day 0 and day 2: 2.5 μg/mL of Bordetella pertussis toxin ? i.p. ? 200 μL
Note
1. Once peptide and CFA emulsion is formed, it can be stored at 4 °C for a few hours or used immediately.
2. Symptoms appear approximately 10-15 days after immunization.
3. When mice have clinical symptoms of EAE, hydrated food is placed on the cage floor to facilitate access to these mice.
4. Record parameters every other day at the beginning, and daily from 7th postimmunization day. Body weight decreases usually precedes EAE clinical signs and is a very objective and valuable measure.
Modeling Indicators
Evaluate changes in body weight and clinical scoring: body weight loss, loss of tail tonus, paralyzed tail, hind limb paraparesis, hind limb paralysis, front leg paralysis, tetraplegia, moribund, etc.
prototypical histopathological changes: Luxol fast blue staining of spinal cord for myelin evaluation shows infiltrates and demyelination in EAE animals.
Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808)
Opposite Product(s): /

Animal Model:HLA-DR2 (DRB1*1501) mice[1]
Dosage:200 μg (0.2 mL)
Administration:Intraperitoneal injection; once, for 38 days
Result:Resulted in paralysis of both hind and forelimbs.

storage

Store at -20°C

References

[1]. de march a k, de bouwerie m, kolopp-sarda m n, et al. anti-myelin oligodendrocyte glycoprotein b-cell responses in multiple sclerosis[j]. journal of neuroimmunology, 2003, 135(1): 117-125.
[2]. slavin a, ewing c, liu j, et al. induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein[j]. autoimmunity, 1998, 28(2): 109-120.
[3]. rich c, link j m, zamora a, et al. myelin oligodendrocyte glycoprotein‐35–55 peptide induces severe chronic experimental autoimmune encephalomyelitis in hla‐dr2‐transgenic mice[j]. european journal of immunology, 2004, 34(5): 1251-1261.
[4]. slavin a, ewing c, liu j, et al. induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein[j]. autoimmunity, 1998, 28(2): 109-120.

Mog (35-55) Preparation Products And Raw materials

Raw materials

Preparation Products

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Mog (35-55) Suppliers

China 150 France 2 Germany 1 India 2 Japan 1 Switzerland 2 United Kingdom 3 United States 16 Global 177
Hangzhou Peptidego Biotech Co.,Ltd.
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0571-87213919
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Eric@peptidego.com
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China
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Cellmano Biotech Limited
Tel
0551-65326643 18156095617
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0551-65326641
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info@cellmano.com
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China
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1010
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Taiyuan Bailihengkang Biotechnology Co., Ltd
Tel
19135651983
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18611134419@163.com
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China
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4416
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ZHEJIANG HUAJUN PHARMACEUTICAL CO., LTD
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0571-17315361885 17315361885
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15007824@QQ.COM
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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Alabiochem Tech.Co., Ltd.
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512-58900862 400-0707518
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0086-512-56765862
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sales@alabiochem.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
Fax
86-21-61263399
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ymbetter@glbiochem.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
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View Lastest Price from Mog (35-55) manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
Mog (35-55) 149635-73-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2025-10-07
RongNa Biotechnology Co.,Ltd
Product
Mog (35-55) 149635-73-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Shandong Hanjiang Chemical Co., Ltd
Product
MOG 35-55 149635-73-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-11

149635-73-4, Mog (35-55)Related Search:

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  • 149635-73-4
  • C118H177N35O29S
  • peptide
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