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Mog (35-55)

Product Name
Mog (35-55)
CAS No.
149635-73-4
Chemical Name
Mog (35-55)
Synonyms
MOG (35-55);MEVGWYRSPFSRVVHLYRNGK;MK21;MOG (35-55) TFA;MOG (35-55), RAT;MOG (MOUSE, RAT);MOG (35-55), MOUSE, RAT;MOG (RAT, MOUSE, 35-55);MOG (35-55) (rat, Mouse);H-MEVGWYRSPFSRVVHLYRNGK-OH
CBNumber
CB8355199
Molecular Formula
C118H177N35O29S
Formula Weight
2581.95
MOL File
149635-73-4.mol
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Mog (35-55) Property

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
≥32.25 mg/mL in H2O; insoluble in EtOH; ≥86 mg/mL in DMSO
form 
solid
Water Solubility 
Soluble to 0.50 mg/ml in water
Sequence
H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-VAL-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
InChI
InChI=1/C118H177N35O29S/c1-61(2)47-80(103(169)143-81(49-66-30-34-70(156)35-31-66)104(170)139-75(26-17-42-129-116(122)123)99(165)145-86(53-90(121)158)98(164)133-56-91(159)136-79(115(181)182)25-15-16-41-119)142-108(174)85(52-69-55-128-60-135-69)147-112(178)95(63(5)6)152-113(179)96(64(7)8)151-101(167)77(28-19-44-131-118(126)127)141-109(175)87(58-154)148-106(172)83(48-65-21-11-10-12-22-65)146-110(176)89-29-20-45-153(89)114(180)88(59-155)149-100(166)76(27-18-43-130-117(124)125)140-105(171)82(50-67-32-36-71(157)37-33-67)144-107(173)84(51-68-54-132-74-24-14-13-23-72(68)74)137-92(160)57-134-111(177)94(62(3)4)150-102(168)78(38-39-93(161)162)138-97(163)73(120)40-46-183-9/h10-14,21-24,30-37,54-55,60-64,73,75-89,94-96,132,154-157H,15-20,25-29,38-53,56-59,119-120H2,1-9H3,(H2,121,158)(H,128,135)(H,133,164)(H,134,177)(H,136,159)(H,137,160)(H,138,163)(H,139,170)(H,140,171)(H,141,175)(H,142,174)(H,143,169)(H,144,173)(H,145,165)(H,146,176)(H,147,178)(H,148,172)(H,149,166)(H,150,168)(H,151,167)(H,152,179)(H,161,162)(H,181,182)(H4,122,123,129)(H4,124,125,130)(H4,126,127,131)/t73-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,94-,95-,96-/s3
InChIKey
JMTCEFUSRHYJBF-LTFOILMJNA-N
SMILES
N1(CCC[C@H]1C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1C=CC(=CC=1)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O)CC(N)=O)C(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1C=CC(=CC=1)O)NC(=O)[C@@H](NC(CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(O)=O)NC([C@H](CCSC)N)=O)=O)CC1C2C=CC=CC=2NC=1 |&1:4,8,19,25,36,43,50,60,68,80,91,99,114,120,131,143,150,157,165,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2568
Product name
MOG(35-55)
Packaging
1
Price
$229
Updated
2021/12/16
ApexBio Technology
Product number
A8306
Product name
MOG(35-55)
Packaging
5mg
Price
$294
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0003907
Product name
MOG (35-55)-MOUSE, RAT
Purity
95.00%
Packaging
1MG
Price
$733.72
Updated
2021/12/16
ApexBio Technology
Product number
A8306
Product name
MOG(35-55)
Packaging
1mg
Price
$98
Updated
2021/12/16
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Mog (35-55) Chemical Properties,Usage,Production

Description

MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.

Uses

Mog (35-55) can be used as an antigen immunized C57BL/6J mice to induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.

Biological Activity

mog (35-55) is a truncated peptide derived from the human myelin oligodendrocyte glycoprotein (mog). mog, a member of the immunoglobulin superfamily, is expressed wildly in the central nervous system. in mouse and rat models for human multiple sclerosis, mog is involved in inducing the experimental autoimmune encephalomyelitis. humoral auto-immunity to the myelin oligodendrocyte glycoprotein (mog) may be associated with the pathogenesis of multiple sclerosis (ms) [1].mog (35-55) is involved in inducing autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination [2]. in hla-dr2-transgenic mice, myelin oligodendrocyte glycoprotein-35-55 peptide induced severe chronic experimental autoimmune encephalomyelitis [3].mog35-55 was highly encephalitogenic and could induce strong t and b cell responses in rats [4]. in nod/lt mice (h-2g7) and c57bl/6 mice (h-2b), single injection of mog35-55 in cfa could induce ms-like disease [4].

storage

Store at -20°C

References

[1]. de march a k, de bouwerie m, kolopp-sarda m n, et al. anti-myelin oligodendrocyte glycoprotein b-cell responses in multiple sclerosis[j]. journal of neuroimmunology, 2003, 135(1): 117-125.
[2]. slavin a, ewing c, liu j, et al. induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein[j]. autoimmunity, 1998, 28(2): 109-120.
[3]. rich c, link j m, zamora a, et al. myelin oligodendrocyte glycoprotein‐35–55 peptide induces severe chronic experimental autoimmune encephalomyelitis in hla‐dr2‐transgenic mice[j]. european journal of immunology, 2004, 34(5): 1251-1261.
[4]. slavin a, ewing c, liu j, et al. induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein[j]. autoimmunity, 1998, 28(2): 109-120.

Mog (35-55) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mog (35-55) manufacturers

Dorne Chemical Technology co. LTD
Product
Mog (35-55) 149635-73-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Zibo Hangyu Biotechnology Development Co., Ltd
Product
ACTH (1-14) 149635-73-4
Price
US $0.10-0.30/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-01-03
Shanghai Aosiris new Material Technology Co., LTD
Product
Mog (35-55) 149635-73-4
Price
US $3.00-1.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10 tons
Release date
2024-04-19

149635-73-4, Mog (35-55)Related Search:


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  • L-Lysine, L-methionyl-L-α-glutamyl-L-valylglycyl-L-tryptophyl-L-tyrosyl-L-arginyl-L-seryl-L-prolyl-L-phenylalanyl-L-seryl-L-arginyl-L-valyl-L-valyl-L-histidyl-L-leucyl-L-tyrosyl-L-arginyl-L-asparaginylglycyl-
  • H-MET-GLU-VAL-GLY-TRP-TYR-ARG-SER-PRO-PHE-SER-ARG-VAL-VAL-HIS-LEU-TYR-ARG-ASN-GLY-LYS-OH USP/EP/BP
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  • L-Lysine,L-methionyl-L-a-glutamyl-L-valylglycyl-L-tryptophyl-L-tyrosyl-L-arginyl-L-seryl-L-prolyl-L-phenylalanyl-L-seryl-L-arginyl-L-valyl-L-valyl-L-histidyl-L-leucyl-L-tyrosyl-L-arginyl-L-asparaginylglycyl-
  • 149635-73-4
  • C118H177N35O29S
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