Inositol nicotinate
- Product Name
- Inositol nicotinate
- CAS No.
- 6556-11-2
- Chemical Name
- Inositol nicotinate
- Synonyms
- INOSITOL;INOSITOL HEXANICOTINATE;hexanicotinate;dilcit;Palohex;WIN9154;hexopal;linodil;mesonex;mesotal
- CBNumber
- CB4411387
- Molecular Formula
- C42H30N6O12
- Formula Weight
- 810.72
- MOL File
- 6556-11-2.mol
Inositol nicotinate Property
- Melting point:
- 254-256 °C(lit.)
- Boiling point:
- 755.54°C (rough estimate)
- Density
- 1.3348 (rough estimate)
- refractive index
- 1.6400 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
- pka
- 3.92±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Merck
- 13,5002
- InChI
- InChI=1S/C42H30N6O12/c49-37(25-7-1-13-43-19-25)55-31-32(56-38(50)26-8-2-14-44-20-26)34(58-40(52)28-10-4-16-46-22-28)36(60-42(54)30-12-6-18-48-24-30)35(59-41(53)29-11-5-17-47-23-29)33(31)57-39(51)27-9-3-15-45-21-27/h1-24,31-36H/t31-,32-,33-,34+,35-,36-
- InChIKey
- MFZCIDXOLLEMOO-GYSGTQPESA-N
- SMILES
- [C@@H]1(OC(C2=CC=CN=C2)=O)[C@@H](OC(C2=CC=CN=C2)=O)[C@H](OC(C2=CC=CN=C2)=O)[C@@H](OC(C2=CC=CN=C2)=O)[C@H](OC(C2=CC=CN=C2)=O)[C@@H]1OC(C1=CC=CN=C1)=O
- LogP
- 3.945 (est)
- CAS DataBase Reference
- 6556-11-2(CAS DataBase Reference)
- EPA Substance Registry System
- Inositol nicotinate (6556-11-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- I666070
- Product name
- myo-InositolHexanicotinate
- Packaging
- 25g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 293814
- Product name
- Inositol nicotinate
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
- Product number
- MI33322
- Product name
- Inositol nicotinate
- Packaging
- 1kg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- MI33322
- Product name
- Inositol nicotinate
- Packaging
- 2Kg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- 70909
- Product name
- myo-InositolHexanicotinate
- Packaging
- 250mg
- Price
- $620
- Updated
- 2021/12/16
Inositol nicotinate Chemical Properties,Usage,Production
Originator
Hexanicotol,Philadelphia,US,1962
Uses
benzidine substitute
Uses
myo-Inositol Hexanicotinate is an nicotinate conjugate of myo-inositol, an structural basis for a number of secondary messengers.
Definition
ChEBI: Inositol hexanicotinate is an inositol nicotinate. It is functionally related to a nicotinic acid.
Manufacturing Process
100 g of nicotinic acid were suspended in 265 ml of distilled and dried
pyridine without stirring. 68 g of phosphorus oxychloride were added dropwise
to this mixture under continual stirring. The temperature of the reactants,
initially at 20°C, was allowed to rise to about 60°C, and this temperature was
maintained for a further 60 minutes. Thereafter 24.5 g of meso-inositol wereadded gradually, the temperature being controlled so that it did not exceed
about 80°C. The reactants were maintained at this temperature for from 2 to
3 hours, and thereafter the reaction mixture was poured into 500 ml of water.
The pyridine salts formed during the reaction readily dissolved, and the mesoinositol hexanicotinate which had formed crystallized out. The ester was
filtered off and washed with water and acetone or alcohol. Finally, the mesoinositol hexanicotinate was dried at 100°C.
The yield was 90%, the melting point of the product was 258°C to 260°C. and
the chlorine content <0.01%.
brand name
Hexopal (Sterling Winthrop); Linodil (Sterling Winthrop); Palohex (Sterling Winthrop).
Therapeutic Function
Vasodilator
Clinical Use
Peripheral vascular disease
Hyperlipidaemia
Drug interactions
Potentially hazardous interactions with other drugs
Statins: increased risk of myopathy.
Metabolism
Inositol nicotinate is believed to be slowly hydrolysed
to nicotinic acid. The main route of metabolism is then
conversion to N-methylnicotinamide and the 2-pyridone
and 4-pyridone derivatives; nicotinuric acid is also
formed.
Small amounts of nicotinic acid are excreted unchanged
in urine.
Inositol nicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Inositol nicotinate manufacturers
- Product
- Inositol Nicotinate 6556-11-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-06
- Product
- Inositol nicotinate 6556-11-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2024-03-27
- Product
- Inositol nicotinate 6556-11-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%-101%, BP
- Supply Ability
- 1000kg
- Release date
- 2021-08-06