Overview Preparation Uses Toxicity Risk Management References
ChemicalBook > CAS DataBase List > Basic Green 4

Basic Green 4

Overview Preparation Uses Toxicity Risk Management References
Product Name
Basic Green 4
CAS No.
2437-29-8
Chemical Name
Basic Green 4
Synonyms
OXALATE;MALACHITE GREEN OXALATE;Ethanedioate;Oxalate salt;Carboxyformate;BASIC GREEN;Malachite green chloride;MALACHITE GREEN OXALATE SALT;Malachite green oxalate salt Solution in Acetonitrile;CI 42000
CBNumber
CB4412647
Molecular Formula
C52H54N4O12
Formula Weight
927
MOL File
2437-29-8.mol
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Basic Green 4 Property

Melting point:
164°C (dec.)
storage temp. 
room temp
solubility 
110g/l
form 
Powder/Solid
pka
6.9(at 25℃)
Colour Index 
42000
color 
S. No.: 754
PH Range
0.0(YELLOW)-2.0(GREEN); 11.0(GREEN)-13.5(CORLORLESS)
PH
2.4 (10g/l, H2O, 24℃)
Water Solubility 
60 g/L (20 ºC)
λmax
614 nm, 425 nm
Merck 
14,5699
BRN 
3644550
Stability:
Stable. Substances to be avoided include strong oxidizing agents.
Biological Applications
Detecting bacterial growth; treating fish diseases,malignant neoplasm
InChIKey
CNYGFPPAGUCRIC-UHFFFAOYSA-L
CAS DataBase Reference
2437-29-8(CAS DataBase Reference)
EPA Substance Registry System
Malachite green oxalate (2437-29-8)
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Safety

Hazard Codes 
Xn,N,Xi
Risk Statements 
22-41-50/53-63-25-21-40-36/37/38-20/21/22-52/53-51/53-36/38
Safety Statements 
26-39-45-61-60-46-36/37-2-36/37/39-36-22
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
BQ1190000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
32041300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32745
Product name
Malachite Green oxalate salt
Purity
for microscopy, crystalline, S. No.: 754
Packaging
50g
Price
$36.1
Updated
2024/03/01
Sigma-Aldrich
Product number
32745
Product name
Malachite Green oxalate salt
Purity
for microscopy, crystalline, S. No.: 754
Packaging
1kg
Price
$413
Updated
2024/03/01
Sigma-Aldrich
Product number
1.01398
Product name
Malachite green oxalate (C.I.42000)
Purity
for microscopy and for microbiology
Packaging
25g
Price
$46.7
Updated
2022/05/15
Sigma-Aldrich
Product number
1.15942
Product name
Malachite green oxalate (C.I. 42000)
Purity
for microscopy Certistain?
Packaging
100g
Price
$147
Updated
2022/05/15
Sigma-Aldrich
Product number
1.01398
Product name
Malachite green oxalate (C.I.42000)
Purity
for microscopy and for microbiology
Packaging
100g
Price
$231
Updated
2022/05/15
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Basic Green 4 Chemical Properties,Usage,Production

Overview

Basic Green 4 is an organic compound that is also referred to as Malachite Green. It is commonly used in dyes and as an antibacterial . In particular, Basic Green 4 can be categorized under reactive groups such as Pyridines, Phosphines, and Amines; Aromatic, Hydrocarbons; Aliphatic Unsaturated, Hydrocarbons; Conjugated Dienes; Phosphonium Salts and Quaternary Ammonium . The name of the compound is obtained from its resemblance with the color of the mineral malachite. In addition, Basic Green 4 can be seen as dark green crystals characteristic of a distinct metallic luster as well as a blue-green solution when dissolved in water. Basic Green 4 goes by the molecular formula C23H25CIN2 and has a high solubility in ethanol, amyl alcohol, methanol, and water (Cameo Chemicals) . In particular, 1 part of the compound is soluble in 15 parts of water (4.0 x 10 + 4mg/l at 250 C), whereas one part of the compound is also soluble in 15 parts of alcohol . When the compound is heated, its decomposition results in hydrogen chloride and nitrogen oxide, highly toxic fumes. In addition, it is estimated that its vapor pressure is 2.4 x 10 – 13MM Hg at 250 C.

Preparation

To prepare Basic Green 4, 14 grams of benzaldehyde and 35 grams of dimethylaniline are combined with 31.5 grams of concentrated hydrochloric acid and the contents are heated to 1000 C for a period of 24 hours with the aid of a reflux condenser. The alkalinity of the resulting solution is enhanced by sodium hydroxide, then the reacting mass is distilled over steam to get rid of traces of dimethylaniline and benzaldehyde. The addition of 1 liter of water to the leuco base allows for the separation of hard granules. The granules are then filtered and the compound is unbound from alkali .
Notably, the oxidation of the leuco base starts by melting 10g of the base over heat and adding a mixture of 4g of acetic acid and 27g of hydrochloric acid and about 3000ml of water. Nonetheless, 7.5g of a fine paste comprising refined lead oxide is gradually mixed in while stirring should continue for about 2 hours after the initial addition. Moreover, the unreacted lead oxide is obtained through filtration and the resulting filtrate is exposed to heat until it attains its boiling point, after which sodium sulfate is incorporated to separate excess lead. The resulting solution is then placed under heat to bring it to boil for effective precipitation with sodium hydroxide. Upon cooling, it is then filtered, washed, dehydrated, and further broken down in light petroleum, then impurities are filtered off, the resulting solution is evaporated to remove petrol, which yields pure Basic Green 4.

Uses

Basic Green 4 is used in Local, Anti-Infective Agents; Industrial, Fungicides. As an internal antiseptic, it is administered to treat canine dysentery ad calf scours, whereas as an external antiseptic it can be applied to abrasions and infected wounds as a triple dye that consists of gentian violet, brilliant green, and rivanol . Malachite green oxalate (arylmethane dye) is also used as a remedy for mycotic infections in aquaculture. Traditionally, malachite green is used as a dye .

Toxicity

Ingestion, inhalation or skin contact with Basic Green 4 can result in critical injuries and in some cases death. In particular, when one come in contact with the molten form of the substance they may experience acute burns on their eyes and skin. It is worth noting that the effects may be delayed upon inhalation or even contact. Moreover, exposure of the element to fire may result in the production of toxic, corrosive and irritating gases. Furthermore, runoff drawn from dilution with water or fire control may also be highly toxic or corrosive in a way that results in pollution .

Risk Management

Evacuation and Isolation are the most instant precautionary measures for either spills or fire. In particular, for solid spills, isolation should be restricted to 25metres whereas for liquid leaks or spills isolation should be restricted to 50metres. In case a tank is involved in a fire accident then isolation should be restricted to 800metres . To fight small fires, use CO2, dry chemical, alcohol-proof foam or a water spray. For massive fires, caution should be taken and the fire should be fought from a distance with monitor nozzles or unmanned hoses to ensure that water does not get into the tanks . Breathing apparatus and protective clothing should always be worn during firefighting. For first aid upon contact, one should flush water on their eyes or skin for about 20 minutes before contacting medical personnel.

References

  1. Barrowcliff, Marmaduke. Organic Medicinal Chemicals (Synthetic and Natural). Chizine Publications, 2018. 
  2. Cameo Chemicals. C.I Basic Green 4. National Oceanic and Atmospheric Administration, 2018. Web. 
  3. PubChem. Basic Green 4. National Center for Biotechnology Information, 2018. Web. Rossoff, Irving .S. Handbook of Veterinary Drugs. Springer Publishing Company, 1974.
 

Chemical Properties

dark green crystals with a metallic luster

Uses

Biological stain, dye reagent, acid base indicator: pH 0.0 yellow, 2.0 green;11.6 green, 14 colorlessMalachite Green oxalate is used as the staining solution for embedded botanical material and as a spore stain. It is also used in studying the photocatalytic degradation with TiO2/WO3. It is employed for determining phosphate in serum and as a reference material in analytical chemistry for the quantification. It is also used as a pH indicator between pH 0.2 - 1.8. It is used as a dye for materials such as silk, leather, and paper.

Uses

Malachite Green oxalate salt has been used:

  • in the preparation of Alexander staining solution for cell viability test
  • in malachite green-ammonium molybdate assay for determining the adenosine triphosphatase (ATPase) activity of binding immunoglobulin protein (BiP)
  • as a hydrophobic ion, to study the label-free molecular transport in the living cell membranes of Escherichia coli in real time by second-harmonic generation (SHG) method

Definition

A salt or ester of oxalicacid.

General Description

Malachite Green is used for bacterial spore staining by Schaeffer and Fulton`s method. It can also be used in place of methyl green in the Pappenheim stain, when combined with the Gram stain.

Biochem/physiol Actions

Malachite green is used in the treatment of fungal and parasitic infections in fish.

Basic Green 4 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Basic Green 4 manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Basic Green 4 2437-29-8
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22
Hebei Kingfiner Technology Development Co.Ltd
Product
Basic Green 4 2437-29-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2023-06-14
Winchem industrial co limited
Product
Basic Yellow 96 2437-29-8
Price
US $0.00/kg
Min. Order
25kg
Purity
1
Supply Ability
20mt
Release date
2022-12-28

2437-29-8, Basic Green 4Related Search:

3-Dimethylaminopropylamine Cupric carbonate basic Alkaline Phosphatase Copper(II) sulfate pentahydrate BASIC GREEN,C.I.Basic Green 5【zinc salt】 Ammonium oxalate Oxalic acid dihydrate Oxalic acid AMMONIUM OXALATE MONOHYDRATE Pigment Basic Malachite Green Lake MALACHITE GREEN CARBINOL HYDROCHLORIDE Basovict Malachite Green,Rifa Basic Malachite Green,Simbase Malachite Green Zn free,Tokyo Aniline Malachite Green. METHYLENE GREEN, ZINC CHLORIDE DOUBLE SA LT (BASIC GREEN 5, C.I. 52020),Basic Green 5 Pigment Green 18 Pigment Fast Malachite Green Lake LEUCOMALACHITE GREEN D6 C.I. Basic Green 4, leuco base,MALACHITE GREEN LEUCO BASE,Malachite green leuco MALACHITE GREEN G,MALACHITE GREEN OXALATE CI.NO. 42000,BASIC GREEN 1,BASIC GREEN I,BASIC GREEN Y,MALACHITE GREEN OXALATE CI.NO. 42000

  • Malachite green oxalate salt Solution in Acetonitrile
  • VICTORIA GREEN B
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  • MALACHITE GREEN OXALATE SALT
  • MALACHITE GREEN OXALATE
  • BASIC GREEN 4 OXALATE SALT
  • BASIC GREEN 4
  • BASIC GREEN
  • DIAMOND GREEN P EXTRA
  • DIAMOND GREEN B
  • DIAMOND GREEN BX
  • CI NO 42000
  • Malachite Green, Oxalate [Sensitive spectrophotometric reagent for PO4]
  • C.I. Basic Green 4 (oxalate)
  • Basic Green 4, N,N,Nμ,Nμ-Tetramethyl-4,4μ-diaminotriphenylcarbenium oxalate
  • Ammonium, [4-[p-(dimethylamino)-.alpha.-phenylbenzylidene]-2,5-cyclohexadien-1-ylidene]dimethyl-, oxalate (1:1), oxalate (1:1)
  • New Victoria Green
  • thanedioic acid, ion(1-), N-[4-[[4-(dimethylamino)phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-methylmethanaminium, ethanedioate (2:1)
  • C.I.42000【oxalate】
  • Carboxyformate
  • Ethanedioate
  • Oxalic acid dianion
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  • Malachite Green oxalate,pure,certified
  • Malachite Green oxalate,pure,high purity biological stain
  • Ammonium,[4-[p-(dimethylamino)-.alpha.-phenylbenzylidene]-2,5-cyclohexadien-1-ylidene]-dimethyl-,oxalate(2:1),oxalate(1:1)
  • idene)-dimethyl-,oxalate(2:1),oxalate(1:1)
  • n-1-ylidene]-n-methyl-,ethanedioate,ethanedioate(2:2:1)
  • MALACHITE GREEN OXALATERESEARCH GRADE
  • Malachite Green oxalate salt,N,N,N′,N′-Tetramethyl-4,4′-diaminotriphenylcarbenium oxalate, Basic Green 4
  • Schaeffer and Fulton Spore Stain Solution A,Malachite Green Solution according to Schaeffer and Fulton
  • Malachite green oxalate, C.I. 42000, reagent and microscopy grade
  • Malachit Green Oxalate
  • China Green Light green N
  • Malachite Green oxalate, high purity biological stain, pure 100GR
  • Malachite Green oxalate, high purity biological stain, pure 25GR
  • TB-COLOR MALACHITE GREEN-(OXALATE)
  • SOLID GREEN O
  • MALACHITE GREEN OXALATE (C.I. 42000) GR
  • MALACHITE GREEN (OXALATE) (C.I. 42000) F
  • CI 42000 OXALATE SALT
  • CI 42000
  • LIGHT GREEN N
  • Diamond green B,BX
  • Malachite green chloride
  • Victoria green B or WB
  • Malachite Green oxalate, certified, pure
  • Malachite Green oxalate, high purity biological stain, pure
  • bis[[4-[4-(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium] oxalate, dioxalate
  • MALACHITE GREEN SOLUTION, 1% IN WATER
  • MALACHITE GREEN OXALATE, CERTIFIED (C.I. 42000)
  • MALACHITE GREEN OXALATE VETRANAL, 250
  • MALACHITE GREEN, FOR MICROSCOPY
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  • MALACHITE GREEN OXALATE, CERTIFIED
  • MALACHITE GREEN OXALATE (C.I. 42000), CERTIFIED GRADE
  • MALACHITE GREEN OXALATE (C.I. 42000)
  • MALACHITE GREEN OXALATE (C.I. 42000), SOLUTION AQUEOUS