6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Product Name
- 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- CAS No.
- 873383-11-0
- Chemical Name
- 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Synonyms
- 6-bromo-1-methylpyridin-2-one;6-Bromo-1-methylpyridin-2(1H);6-Bromo-1-methyl-2(1H)-pyridone;6-Bromo-1-methylpyridine-2(1H)one;6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;6-Bromo-1-methyl-1H-pyridin-2-one;2(1H)-Pyridinone, 6-broMo-1-Methyl-;6-Bromo-1-methyl-1,2-dihydropyridin-2-one
- CBNumber
- CB4413543
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 873383-11-0.mol
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Property
- Boiling point:
- 287.1±33.0 °C(Predicted)
- Density
- 1.664±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.98±0.62(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B446290
- Product name
- 6-Bromo-1-methylpyridin-2(1H)-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B446290
- Product name
- 6-Bromo-1-methylpyridin-2(1H)-one
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3813AC
- Product name
- 6-Bromo-1-methylpyridin-2(1H)-one
- Packaging
- 5g
- Price
- $705
- Updated
- 2021/12/16
- Product number
- HCH0367681
- Product name
- 6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.21
- Updated
- 2021/12/16
- Product number
- A112089
- Product name
- 6-Bromo-1-methylpyridin-2(1H)-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $634
- Updated
- 2021/12/16
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Chemical Properties,Usage,Production
Synthesis
27992-32-1
74-88-4
873383-11-0
In a dry Schlenk test tube, 2-bromo-6-hydroxypyridine (3.43 g, 31.44 mmol) was dissolved in 50 mL of 1,4-dioxane and KOt-Bu (8.69 g, 62.88 mmol) was added. The reaction mixture was stirred at 100 °C for 2 h and subsequently cooled to room temperature. Iodomethane (19.6 mL, 314.41 mmol) was added dropwise and the mixture was stirred at 80 °C for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was partitioned between dichloromethane (DCM) and water. Extraction was carried out using DCM (3 times) and the organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4). After filtration, the solvent was evaporated to obtain the crude product. Purification by column chromatography (eluent: 5% methanol in DCM solution) afforded 6-bromo-1-methylpyridin-2(1H)-one (orange solid, 3.70 g, 96% yield).
References
[1] Synlett, 2015, vol. 26, # 11, p. 1557 - 1562
[2] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0412
[3] Patent: WO2015/92713, 2015, A1. Location in patent: Page/Page column 323
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7076 - 7080
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
6-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Suppliers
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- Country
- The Netherlands
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